TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv2198c/mmpS3:

update plot	correlation	link to info on gene
Rv3044/fecB	(cc=0.8003)	info on Rv3044/fecB
Rv2256c/-	(cc=0.7801)	info on Rv2256c/-
Rv2221c/glnE	(cc=0.7463)	info on Rv2221c/glnE
Rv3789/-	(cc=0.7429)	info on Rv3789/-
Rv2400c/subI	(cc=0.7277)	info on Rv2400c/subI
Rv3035/-	(cc=0.7275)	info on Rv3035/-
Rv1340/rphA	(cc=0.7142)	info on Rv1340/rphA
Rv2246/kasB	(cc=0.7108)	info on Rv2246/kasB
Rv2397c/cysA1	(cc=0.6654)	info on Rv2397c/cysA1
Rv1157c/-	(cc=0.6302)	info on Rv1157c/-

Correlation of Rv2198c/mmpS3 with Rv3044/fecB

Normalized LFCs for Rv2198c/mmpS3:
(description and provenance of datasets)

	Rv2198c/mmpS3	Rv3044/fecB
Fe_supp_jason_reseq	1.897	0.0
low_pH_jason_reseq	0.0	0.0
NO_jason_reseq	0.0	0.0
B6_jason_reseq	0.0	0.0
MHCII_jason_reseq	0.0	0.0
Isoniazid02	0.469	-0.551
Rifampicin4	-0.712	-1.026
Ethambutol3	-0.153	-0.461
Meropenem3	-0.315	-0.454
Vancomycin16	-0.698	-1.005
Rv2680_day32	-0.33	0.0
H37Rv_KO_MarP	-6.0	-4.826
hypoxia_3wks	0.0	0.0
hypoxia_6wks	-0.209	0.0
glycerol	0.709	0.0
cholesterol	0.145	0.0
AJ	0.0	0.0
Bibs02	0.0	0.0
Bibs02c	0.0	0.0
BL6	0.0	0.0
BL6a	0.0	0.0
BXD01	0.0	0.0
BXD010	0.0	0.0
BXD011	0.0	0.0
BXD03	0.0	0.0
BXD04	0.0	0.0
BXD05	0.135	0.0
BXD06	0.0	0.0
BXD07	0.0	0.0
BXD08	0.0	0.0
BXD09	0.0	0.0
CAST	0.0	0.0
CCcont	1.492	2.164
DS01	0.0	0.0
DS02	0.0	0.0
DS04	0.533	0.0
DS0c	0.0	0.0
GP01	0.0	0.0
GP02	0.0	0.0
GP0c	0.0	0.0
NOD	0.0	0.0
NZO	0.0	0.0
PWK	0.0	0.0
H37Rv_KO_CtpC	0.162	0.0
H37Rv_KO_CtpD	0.241	0.0
H37Rv_KO_Rv1272	0.0	0.0
H37Rv_KO_SugABC	0.348	0.0
H37Rv_KO_MbtN	0.362	0.103
Trans05	0.0	0.0
macrophage_unactivated	0.0	0.0
IL1	0.0	0.0
Rapamycin	0.0	0.0
Tcell	0.0	0.0
GMCSF	0.0	0.0
IFNab	0.0	0.0
IFNg	0.0	0.0
IFNg_GMCSF1	0.0	0.0
Rv1432_day32	0.0	0.0
Rv1565c_day32	0.0	0.0
secA2_input	-0.456	-0.146
delta_Rv3594	1.937	0.243
delta_Rv3717	0.532	0.891
delta_Rv3811	0.376	-1.096
delta_Rv0954	0.152	-0.802
PonA1	0.566	-0.945
EccD1_KO	-4.654	-2.937
EspI_KO	-4.954	-2.264
PE35_KO	0.204	0.601
PPE68_KO	-1.177	0.342
glycerol2	-0.369	-0.68
lignocerate	-0.153	-0.591
oleate	-0.373	-0.688
phosphatidylcholine	-0.368	-0.679
acetate	2.352	-0.806
glucAc	-0.272	-0.36
Rv0950ko	-2.044	-4.632
Rv1096ko	-6.0	-3.839
Rv3684ko	-0.305	-0.337
delta_otsA_trehalose	-0.4	0.0