TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv2191/-:

update plot	correlation	link to info on gene
Rv0183/-	(cc=0.5368)	info on Rv0183/-
Rv2892c/PPE45	(cc=0.4812)	info on Rv2892c/PPE45
Rv0515/-	(cc=0.4747)	info on Rv0515/-
Rv0878c/PPE13	(cc=0.4624)	info on Rv0878c/PPE13
Rv0336/-	(cc=0.462)	info on Rv0336/-
Rv1743/pknE	(cc=0.4557)	info on Rv1743/pknE
Rv1546/-	(cc=0.4464)	info on Rv1546/-
Rv2994/-	(cc=0.4423)	info on Rv2994/-
Rv0458/-	(cc=0.4312)	info on Rv0458/-
Rv0877/-	(cc=0.4301)	info on Rv0877/-

Correlation of Rv2191/- with Rv0877/-

Normalized LFCs for Rv2191/-:
(description and provenance of datasets)

	Rv2191/-	Rv0877/-
Fe_supp_jason_reseq	0.0	-1.639
low_pH_jason_reseq	-0.979	0.724
NO_jason_reseq	0.318	3.305
B6_jason_reseq	0.376	1.22
MHCII_jason_reseq	0.0	-2.252
Isoniazid02	0.437	5.11
Rifampicin4	0.712	0.566
Ethambutol3	0.311	1.454
Meropenem3	0.694	1.624
Vancomycin16	0.576	-0.239
Rv2680_day32	0.546	1.68
H37Rv_KO_MarP	-0.727	-1.421
hypoxia_3wks	0.622	0.79
hypoxia_6wks	1.019	3.067
glycerol	-0.108	-1.593
cholesterol	0.435	-1.617
AJ	-0.168	-0.034
Bibs02	0.348	-1.644
Bibs02c	0.25	-1.478
BL6	0.597	1.26
BL6a	0.469	0.319
BXD01	0.088	2.472
BXD010	0.158	1.577
BXD011	0.713	2.37
BXD03	-0.054	0.932
BXD04	0.549	2.958
BXD05	-0.103	1.299
BXD06	0.37	2.021
BXD07	0.218	1.091
BXD08	0.71	2.432
BXD09	0.333	1.504
CAST	0.422	1.119
CCcont	-0.423	-0.938
DS01	0.756	-0.753
DS02	0.181	0.744
DS04	0.533	0.35
DS0c	0.476	-1.092
GP01	0.499	-0.222
GP02	0.694	1.341
GP0c	0.276	0.237
NOD	0.039	0.335
NZO	0.246	0.926
PWK	0.381	2.786
H37Rv_KO_CtpC	0.225	2.358
H37Rv_KO_CtpD	-0.268	0.373
H37Rv_KO_Rv1272	0.618	0.206
H37Rv_KO_SugABC	0.324	0.442
H37Rv_KO_MbtN	0.229	1.093
Trans05	0.515	1.163
macrophage_unactivated	-0.136	-2.43
IL1	0.225	0.264
Rapamycin	0.147	-1.108
Tcell	-0.202	0.6
GMCSF	0.156	-0.708
IFNab	-0.342	-1.784
IFNg	-0.032	0.345
IFNg_GMCSF1	-0.522	0.085
Rv1432_day32	0.893	1.226
Rv1565c_day32	-0.081	-2.51
secA2_input	0.607	-0.238
delta_Rv3594	-0.281	-1.713
delta_Rv3717	-0.26	0.111
delta_Rv3811	-0.512	-2.104
delta_Rv0954	-0.142	-1.55
PonA1	-0.015	-1.43
EccD1_KO	0.474	-0.493
EspI_KO	0.291	-0.325
PE35_KO	-0.755	-1.642
PPE68_KO	-0.582	-1.417
glycerol2	0.185	0.035
lignocerate	0.387	-0.843
oleate	0.359	2.003
phosphatidylcholine	0.197	-0.332
acetate	-0.066	-0.14
glucAc	0.227	-0.315
Rv0950ko	0.184	-0.018
Rv1096ko	0.287	0.199
Rv3684ko	0.255	1.064
delta_otsA_trehalose	1.379	-0.393