TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv2191/-:

update plot	correlation	link to info on gene
Rv0183/-	(cc=0.5368)	info on Rv0183/-
Rv2892c/PPE45	(cc=0.4812)	info on Rv2892c/PPE45
Rv0515/-	(cc=0.4747)	info on Rv0515/-
Rv0878c/PPE13	(cc=0.4624)	info on Rv0878c/PPE13
Rv0336/-	(cc=0.462)	info on Rv0336/-
Rv1743/pknE	(cc=0.4557)	info on Rv1743/pknE
Rv1546/-	(cc=0.4464)	info on Rv1546/-
Rv2994/-	(cc=0.4423)	info on Rv2994/-
Rv0458/-	(cc=0.4312)	info on Rv0458/-
Rv0877/-	(cc=0.4301)	info on Rv0877/-

Correlation of Rv2191/- with Rv0458/-

Normalized LFCs for Rv2191/-:
(description and provenance of datasets)

	Rv2191/-	Rv0458/-
Fe_supp_jason_reseq	0.0	-0.571
low_pH_jason_reseq	-0.979	-0.368
NO_jason_reseq	0.318	-0.26
B6_jason_reseq	0.376	-0.192
MHCII_jason_reseq	0.0	0.456
Isoniazid02	0.437	0.533
Rifampicin4	0.712	0.382
Ethambutol3	0.311	0.246
Meropenem3	0.694	1.113
Vancomycin16	0.576	0.353
Rv2680_day32	0.546	0.005
H37Rv_KO_MarP	-0.727	0.286
hypoxia_3wks	0.622	0.542
hypoxia_6wks	1.019	1.173
glycerol	-0.108	-1.732
cholesterol	0.435	-0.313
AJ	-0.168	0.197
Bibs02	0.348	0.042
Bibs02c	0.25	0.764
BL6	0.597	-0.639
BL6a	0.469	0.749
BXD01	0.088	-0.037
BXD010	0.158	-0.086
BXD011	0.713	0.208
BXD03	-0.054	0.049
BXD04	0.549	0.35
BXD05	-0.103	0.136
BXD06	0.37	0.27
BXD07	0.218	-0.148
BXD08	0.71	0.289
BXD09	0.333	-0.053
CAST	0.422	0.053
CCcont	-0.423	-0.314
DS01	0.756	0.329
DS02	0.181	0.561
DS04	0.533	-0.301
DS0c	0.476	0.826
GP01	0.499	-0.666
GP02	0.694	0.325
GP0c	0.276	-0.266
NOD	0.039	-0.537
NZO	0.246	-0.038
PWK	0.381	0.027
H37Rv_KO_CtpC	0.225	-0.093
H37Rv_KO_CtpD	-0.268	-0.519
H37Rv_KO_Rv1272	0.618	-0.088
H37Rv_KO_SugABC	0.324	-0.248
H37Rv_KO_MbtN	0.229	0.205
Trans05	0.515	0.138
macrophage_unactivated	-0.136	-0.129
IL1	0.225	0.202
Rapamycin	0.147	0.018
Tcell	-0.202	0.15
GMCSF	0.156	-0.285
IFNab	-0.342	-0.662
IFNg	-0.032	-0.425
IFNg_GMCSF1	-0.522	0.126
Rv1432_day32	0.893	0.665
Rv1565c_day32	-0.081	-0.516
secA2_input	0.607	0.285
delta_Rv3594	-0.281	-0.543
delta_Rv3717	-0.26	0.135
delta_Rv3811	-0.512	-0.375
delta_Rv0954	-0.142	-0.384
PonA1	-0.015	1.116
EccD1_KO	0.474	0.204
EspI_KO	0.291	0.177
PE35_KO	-0.755	-1.0
PPE68_KO	-0.582	-0.608
glycerol2	0.185	1.655
lignocerate	0.387	-1.05
oleate	0.359	1.313
phosphatidylcholine	0.197	-0.493
acetate	-0.066	0.191
glucAc	0.227	0.41
Rv0950ko	0.184	-0.286
Rv1096ko	0.287	0.633
Rv3684ko	0.255	0.904
delta_otsA_trehalose	1.379	0.888