TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv2187/fadD15:

update plot	correlation	link to info on gene
Rv3263/-	(cc=0.5525)	info on Rv3263/-
Rv1151c/-	(cc=0.5079)	info on Rv1151c/-
Rv2456c/-	(cc=0.4841)	info on Rv2456c/-
Rv1210/tagA	(cc=0.4595)	info on Rv1210/tagA
Rv0932c/pstS2	(cc=0.4524)	info on Rv0932c/pstS2
Rv0473/-	(cc=0.4518)	info on Rv0473/-
Rv1387/PPE20	(cc=0.4471)	info on Rv1387/PPE20
Rv0402c/mmpL1	(cc=0.4371)	info on Rv0402c/mmpL1
Rv0877/-	(cc=0.4361)	info on Rv0877/-
Rv1212c/glgA	(cc=0.4331)	info on Rv1212c/glgA

Correlation of Rv2187/fadD15 with Rv1151c/-

Normalized LFCs for Rv2187/fadD15:
(description and provenance of datasets)

	Rv2187/fadD15	Rv1151c/-
Fe_supp_jason_reseq	-0.534	-1.088
low_pH_jason_reseq	-0.303	0.719
NO_jason_reseq	1.124	1.793
B6_jason_reseq	0.165	1.64
MHCII_jason_reseq	-0.597	-0.121
Isoniazid02	0.349	0.631
Rifampicin4	0.16	-0.089
Ethambutol3	-0.011	0.486
Meropenem3	-0.023	0.332
Vancomycin16	-0.406	-0.088
Rv2680_day32	0.836	-0.173
H37Rv_KO_MarP	0.526	0.231
hypoxia_3wks	0.132	-0.203
hypoxia_6wks	0.069	-0.601
glycerol	-0.566	-0.413
cholesterol	-0.14	-0.426
AJ	0.748	0.79
Bibs02	-0.132	0.412
Bibs02c	-0.162	0.273
BL6	-0.034	0.323
BL6a	0.261	0.263
BXD01	0.445	0.458
BXD010	0.405	0.232
BXD011	0.521	0.707
BXD03	0.103	0.603
BXD04	0.201	0.366
BXD05	0.775	-0.113
BXD06	0.581	1.066
BXD07	0.301	0.716
BXD08	0.632	1.429
BXD09	0.407	0.297
CAST	1.44	1.657
CCcont	-0.279	-0.713
DS01	-0.356	0.633
DS02	-0.169	0.583
DS04	0.669	0.502
DS0c	0.093	-0.08
GP01	0.286	-1.312
GP02	0.328	-0.391
GP0c	0.151	-1.32
NOD	0.527	0.984
NZO	0.517	1.261
PWK	0.877	2.998
H37Rv_KO_CtpC	-0.173	1.286
H37Rv_KO_CtpD	-0.006	-0.857
H37Rv_KO_Rv1272	-0.324	-0.255
H37Rv_KO_SugABC	0.547	0.431
H37Rv_KO_MbtN	-0.046	0.025
Trans05	1.157	0.493
macrophage_unactivated	0.161	-0.846
IL1	0.19	-0.196
Rapamycin	0.27	-1.31
Tcell	0.384	1.29
GMCSF	0.185	-1.022
IFNab	-0.478	-1.886
IFNg	0.444	0.045
IFNg_GMCSF1	0.179	-0.666
Rv1432_day32	1.572	2.523
Rv1565c_day32	-0.625	-0.785
secA2_input	-0.376	0.384
delta_Rv3594	0.355	0.216
delta_Rv3717	0.456	0.326
delta_Rv3811	0.274	-0.494
delta_Rv0954	-0.477	0.474
PonA1	-0.417	0.239
EccD1_KO	0.691	1.25
EspI_KO	-0.068	1.757
PE35_KO	0.633	1.771
PPE68_KO	0.25	1.577
glycerol2	0.595	0.706
lignocerate	0.598	0.634
oleate	0.872	4.229
phosphatidylcholine	0.626	0.894
acetate	-0.033	0.208
glucAc	0.868	0.069
Rv0950ko	-0.308	-0.428
Rv1096ko	0.048	-0.784
Rv3684ko	0.262	0.383
delta_otsA_trehalose	-0.626	0.371