TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv1894c/-:

update plot	correlation	link to info on gene
Rv1834/lipZ	(cc=0.6359)	info on Rv1834/lipZ
Rv3295/-	(cc=0.6062)	info on Rv3295/-
Rv1734c/-	(cc=0.5995)	info on Rv1734c/-
Rv0540/-	(cc=0.5729)	info on Rv0540/-
Rv3059/cyp136	(cc=0.5715)	info on Rv3059/cyp136
Rv2633c/-	(cc=0.5691)	info on Rv2633c/-
Rv1467c/fadE15	(cc=0.5609)	info on Rv1467c/fadE15
Rv2030c/-	(cc=0.5563)	info on Rv2030c/-
Rv1041c/-	(cc=0.5561)	info on Rv1041c/-
Rv2642/-	(cc=0.5404)	info on Rv2642/-

Correlation of Rv1894c/- with Rv1041c/-

Normalized LFCs for Rv1894c/-:
(description and provenance of datasets)

	Rv1894c/-	Rv1041c/-
Fe_supp_jason_reseq	-0.472	-0.717
low_pH_jason_reseq	-0.959	-0.604
NO_jason_reseq	0.588	0.034
B6_jason_reseq	0.018	0.426
MHCII_jason_reseq	0.616	0.427
Isoniazid02	-0.904	-0.191
Rifampicin4	-0.125	0.555
Ethambutol3	-0.181	-0.009
Meropenem3	1.114	0.246
Vancomycin16	-0.695	0.077
Rv2680_day32	-0.345	0.092
H37Rv_KO_MarP	0.058	0.443
hypoxia_3wks	-0.283	0.463
hypoxia_6wks	0.079	0.388
glycerol	0.064	0.301
cholesterol	0.043	0.111
AJ	-0.061	0.467
Bibs02	0.083	-0.025
Bibs02c	-0.059	0.878
BL6	-0.702	-0.511
BL6a	-0.41	0.209
BXD01	-0.256	-0.127
BXD010	-0.792	-0.277
BXD011	0.4	-0.311
BXD03	-1.064	-0.22
BXD04	-1.142	-0.262
BXD05	-0.608	-0.019
BXD06	-0.848	-0.157
BXD07	-0.978	-0.602
BXD08	-0.337	-0.325
BXD09	-0.823	-0.392
CAST	0.656	0.317
CCcont	-1.281	-0.997
DS01	0.175	0.424
DS02	-0.129	0.282
DS04	-0.022	0.419
DS0c	-0.233	0.229
GP01	-0.748	-0.156
GP02	0.116	-0.086
GP0c	-0.767	-1.031
NOD	1.357	0.901
NZO	0.244	-0.337
PWK	0.392	0.601
H37Rv_KO_CtpC	-0.069	1.289
H37Rv_KO_CtpD	-0.838	0.169
H37Rv_KO_Rv1272	0.064	-0.104
H37Rv_KO_SugABC	0.722	-0.259
H37Rv_KO_MbtN	0.827	0.018
Trans05	0.568	-0.006
macrophage_unactivated	-0.884	-1.048
IL1	-0.578	-0.833
Rapamycin	-0.957	-1.117
Tcell	-0.541	-0.916
GMCSF	-0.325	-0.462
IFNab	-0.895	-0.973
IFNg	-1.269	-1.328
IFNg_GMCSF1	0.06	-0.267
Rv1432_day32	0.13	0.232
Rv1565c_day32	0.289	0.319
secA2_input	-0.009	0.402
delta_Rv3594	0.217	-0.48
delta_Rv3717	0.019	-0.269
delta_Rv3811	0.311	-0.613
delta_Rv0954	-0.19	-0.112
PonA1	0.473	-0.196
EccD1_KO	0.191	0.618
EspI_KO	0.202	0.559
PE35_KO	0.289	0.648
PPE68_KO	0.042	0.429
glycerol2	0.769	-0.13
lignocerate	0.418	-0.354
oleate	1.127	0.25
phosphatidylcholine	0.973	0.01
acetate	-0.495	-0.218
glucAc	-0.634	-0.478
Rv0950ko	0.959	0.353
Rv1096ko	0.576	0.48
Rv3684ko	0.75	-0.062
delta_otsA_trehalose	0.739	0.558