TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv1795/eccD5:

update plot	correlation	link to info on gene
Rv1796/mycP5	(cc=0.9758)	info on Rv1796/mycP5
Rv1782/eccB5	(cc=0.9506)	info on Rv1782/eccB5
Rv1794/-	(cc=0.9383)	info on Rv1794/-
Rv1783/eccC5	(cc=0.9287)	info on Rv1783/eccC5
Rv1797/eccE5	(cc=0.8763)	info on Rv1797/eccE5
Rv1063c/-	(cc=0.4391)	info on Rv1063c/-
Rv1267c/embR	(cc=0.4194)	info on Rv1267c/embR
Rv3399/-	(cc=0.413)	info on Rv3399/-
Rv0538/-	(cc=0.3979)	info on Rv0538/-
Rv2065/cobH	(cc=0.3972)	info on Rv2065/cobH

Correlation of Rv1795/eccD5 with Rv1796/mycP5

Normalized LFCs for Rv1795/eccD5:
(description and provenance of datasets)

	Rv1795/eccD5	Rv1796/mycP5
Fe_supp_jason_reseq	0.415	1.07
low_pH_jason_reseq	0.0	0.0
NO_jason_reseq	0.0	0.0
B6_jason_reseq	0.0	0.0
MHCII_jason_reseq	0.0	0.0
Isoniazid02	0.0	0.0
Rifampicin4	0.0	-0.341
Ethambutol3	0.0	-0.153
Meropenem3	0.0	0.701
Vancomycin16	0.0	0.0
Rv2680_day32	0.0	0.0
H37Rv_KO_MarP	5.012	3.913
hypoxia_3wks	0.0	0.0
hypoxia_6wks	0.0	0.0
glycerol	4.046	2.817
cholesterol	1.325	1.261
AJ	0.0	0.0
Bibs02	0.0	0.0
Bibs02c	1.028	0.887
BL6	0.0	0.0
BL6a	0.377	0.198
BXD01	0.0	0.0
BXD010	0.0	0.0
BXD011	0.0	0.0
BXD03	0.0	0.0
BXD04	0.0	0.0
BXD05	0.0	0.0
BXD06	0.0	0.0
BXD07	0.0	0.0
BXD08	0.0	0.0
BXD09	0.0	0.0
CAST	0.23	0.0
CCcont	0.149	0.285
DS01	0.0	0.0
DS02	0.0	0.0
DS04	0.0	0.0
DS0c	0.0	0.0
GP01	4.073	4.286
GP02	4.279	3.666
GP0c	5.395	4.971
NOD	0.0	0.0
NZO	0.0	0.0
PWK	0.0	0.0
H37Rv_KO_CtpC	0.0	0.0
H37Rv_KO_CtpD	0.0	0.0
H37Rv_KO_Rv1272	0.0	0.0
H37Rv_KO_SugABC	0.0	0.0
H37Rv_KO_MbtN	0.0	0.0
Trans05	0.0	0.0
macrophage_unactivated	0.0	0.0
IL1	0.0	0.0
Rapamycin	0.0	0.0
Tcell	0.0	0.0
GMCSF	0.0	0.0
IFNab	0.0	0.0
IFNg	0.0	0.0
IFNg_GMCSF1	0.0	0.0
Rv1432_day32	0.0	0.0
Rv1565c_day32	0.0	0.0
secA2_input	0.216	0.216
delta_Rv3594	0.0	-0.211
delta_Rv3717	0.853	0.992
delta_Rv3811	0.0	-0.205
delta_Rv0954	2.536	2.103
PonA1	0.0	-0.159
EccD1_KO	0.0	-0.454
EspI_KO	0.0	-0.394
PE35_KO	0.767	0.368
PPE68_KO	0.442	0.0
glycerol2	0.0	0.0
lignocerate	0.0	0.0
oleate	0.0	0.0
phosphatidylcholine	0.0	0.0
acetate	0.0	0.437
glucAc	0.0	0.0
Rv0950ko	0.38	0.669
Rv1096ko	0.38	0.0
Rv3684ko	0.0	-0.413
delta_otsA_trehalose	0.0	0.133