TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv1558/-:

update plot	correlation	link to info on gene
Rv3633/-	(cc=0.5149)	info on Rv3633/-
Rv2972c/-	(cc=0.4966)	info on Rv2972c/-
Rv0726c/-	(cc=0.439)	info on Rv0726c/-
Rv3312A/-	(cc=0.4323)	info on Rv3312A/-
Rv3451/cut3	(cc=0.4274)	info on Rv3451/cut3
Rv1719/-	(cc=0.3898)	info on Rv1719/-
Rv3826/fadD23	(cc=0.3817)	info on Rv3826/fadD23
Rv0873/fadE10	(cc=0.3783)	info on Rv0873/fadE10
Rv0530/-	(cc=0.3752)	info on Rv0530/-
Rv2459/-	(cc=0.373)	info on Rv2459/-

Correlation of Rv1558/- with Rv0873/fadE10

Normalized LFCs for Rv1558/-:
(description and provenance of datasets)

	Rv1558/-	Rv0873/fadE10
Fe_supp_jason_reseq	0.248	0.892
low_pH_jason_reseq	-1.022	-1.044
NO_jason_reseq	0.058	-0.732
B6_jason_reseq	0.883	0.425
MHCII_jason_reseq	1.104	0.675
Isoniazid02	-0.687	-0.908
Rifampicin4	0.682	0.341
Ethambutol3	-0.305	-0.111
Meropenem3	1.242	-0.593
Vancomycin16	-0.159	-0.525
Rv2680_day32	0.042	0.514
H37Rv_KO_MarP	0.144	0.306
hypoxia_3wks	-0.287	-0.251
hypoxia_6wks	-0.507	0.186
glycerol	-0.503	0.184
cholesterol	-0.504	0.542
AJ	0.462	-0.178
Bibs02	0.487	-0.282
Bibs02c	0.649	0.673
BL6	-0.091	0.014
BL6a	0.317	0.485
BXD01	-0.044	0.187
BXD010	0.523	-0.229
BXD011	0.149	-0.084
BXD03	0.256	-0.209
BXD04	0.326	0.271
BXD05	-0.067	0.411
BXD06	0.24	0.055
BXD07	0.107	0.113
BXD08	0.218	0.251
BXD09	0.189	-0.015
CAST	0.023	-0.34
CCcont	-0.421	-0.065
DS01	0.645	0.394
DS02	0.501	0.487
DS04	0.479	0.08
DS0c	1.358	0.448
GP01	0.343	0.584
GP02	0.554	1.007
GP0c	-0.201	0.131
NOD	-0.436	-0.387
NZO	0.462	0.123
PWK	0.311	-0.185
H37Rv_KO_CtpC	0.312	-0.342
H37Rv_KO_CtpD	0.568	0.489
H37Rv_KO_Rv1272	-1.188	0.61
H37Rv_KO_SugABC	-1.189	0.11
H37Rv_KO_MbtN	0.35	0.058
Trans05	-0.949	-0.131
macrophage_unactivated	0.098	0.253
IL1	0.409	-0.374
Rapamycin	0.543	-0.285
Tcell	0.186	0.072
GMCSF	0.399	0.341
IFNab	-0.269	-0.209
IFNg	0.123	0.139
IFNg_GMCSF1	0.135	-0.396
Rv1432_day32	-0.623	0.175
Rv1565c_day32	-3.116	-0.708
secA2_input	-0.122	-0.131
delta_Rv3594	-0.099	0.459
delta_Rv3717	-0.186	0.0
delta_Rv3811	-0.335	0.446
delta_Rv0954	0.647	0.377
PonA1	0.9	0.521
EccD1_KO	-0.585	0.28
EspI_KO	0.348	0.67
PE35_KO	0.292	0.137
PPE68_KO	0.87	0.0
glycerol2	0.397	0.46
lignocerate	0.385	0.201
oleate	0.72	0.6
phosphatidylcholine	0.469	0.51
acetate	-0.336	-0.298
glucAc	0.241	-0.621
Rv0950ko	0.552	0.021
Rv1096ko	-0.181	-0.486
Rv3684ko	0.095	-0.501
delta_otsA_trehalose	1.305	0.97