TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv1530/adh:

update plot	correlation	link to info on gene
Rv1526c/-	(cc=0.533)	info on Rv1526c/-
Rv1175c/fadH	(cc=0.44)	info on Rv1175c/fadH
Rv2575/-	(cc=0.4046)	info on Rv2575/-
Rv1548c/PPE21	(cc=0.3944)	info on Rv1548c/PPE21
Rv1167c/-	(cc=0.394)	info on Rv1167c/-
Rv0254c/cobU	(cc=0.3911)	info on Rv0254c/cobU
Rv2147c/-	(cc=0.3906)	info on Rv2147c/-
Rv3545c/cyp125	(cc=0.3814)	info on Rv3545c/cyp125
Rv2038c/-	(cc=0.38)	info on Rv2038c/-
Rv2345/-	(cc=0.3752)	info on Rv2345/-

Correlation of Rv1530/adh with Rv1167c/-

Normalized LFCs for Rv1530/adh:
(description and provenance of datasets)

	Rv1530/adh	Rv1167c/-
Fe_supp_jason_reseq	-0.429	-1.156
low_pH_jason_reseq	0.318	0.448
NO_jason_reseq	0.173	1.88
B6_jason_reseq	-1.638	-2.005
MHCII_jason_reseq	-0.594	-2.389
Isoniazid02	-0.509	-2.878
Rifampicin4	0.712	-1.338
Ethambutol3	-0.496	-1.589
Meropenem3	-0.419	-1.935
Vancomycin16	-0.058	-2.921
Rv2680_day32	-0.921	-1.565
H37Rv_KO_MarP	0.667	0.969
hypoxia_3wks	0.0	-0.159
hypoxia_6wks	0.384	-0.213
glycerol	0.541	0.088
cholesterol	0.141	-1.082
AJ	1.365	-1.256
Bibs02	-0.729	-1.06
Bibs02c	-0.409	-0.708
BL6	-0.033	0.775
BL6a	0.369	0.326
BXD01	0.065	0.869
BXD010	-0.033	1.656
BXD011	0.264	0.865
BXD03	1.111	0.642
BXD04	0.0	0.882
BXD05	1.058	0.913
BXD06	0.249	0.495
BXD07	0.258	1.559
BXD08	-0.26	1.349
BXD09	0.534	0.626
CAST	-0.38	0.148
CCcont	0.18	1.736
DS01	-0.123	-0.873
DS02	-0.866	-1.26
DS04	-1.086	-0.228
DS0c	-0.947	0.047
GP01	-0.358	0.8
GP02	-0.934	-0.835
GP0c	0.908	-0.089
NOD	0.854	-1.578
NZO	0.413	-0.614
PWK	-0.102	-1.137
H37Rv_KO_CtpC	0.956	2.015
H37Rv_KO_CtpD	1.399	1.663
H37Rv_KO_Rv1272	1.299	0.455
H37Rv_KO_SugABC	1.981	-0.938
H37Rv_KO_MbtN	0.235	0.299
Trans05	-0.571	0.443
macrophage_unactivated	1.376	0.249
IL1	0.552	0.866
Rapamycin	0.169	0.559
Tcell	0.091	1.636
GMCSF	0.491	0.481
IFNab	0.635	0.048
IFNg	0.561	0.673
IFNg_GMCSF1	-0.273	0.751
Rv1432_day32	-0.697	-1.949
Rv1565c_day32	0.431	-0.499
secA2_input	1.13	0.266
delta_Rv3594	0.603	0.693
delta_Rv3717	0.287	-0.021
delta_Rv3811	-0.126	-0.617
delta_Rv0954	0.809	-0.69
PonA1	0.526	0.0
EccD1_KO	0.599	0.661
EspI_KO	0.077	-0.722
PE35_KO	0.312	0.28
PPE68_KO	0.086	0.55
glycerol2	0.115	-0.319
lignocerate	0.569	-0.196
oleate	0.06	-0.906
phosphatidylcholine	0.521	0.032
acetate	0.924	0.17
glucAc	0.689	0.255
Rv0950ko	-0.706	-1.357
Rv1096ko	-0.881	-1.357
Rv3684ko	-0.413	-1.153
delta_otsA_trehalose	0.621	-0.245