TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv1530/adh:

update plot	correlation	link to info on gene
Rv1526c/-	(cc=0.533)	info on Rv1526c/-
Rv1175c/fadH	(cc=0.44)	info on Rv1175c/fadH
Rv2575/-	(cc=0.4046)	info on Rv2575/-
Rv1548c/PPE21	(cc=0.3944)	info on Rv1548c/PPE21
Rv1167c/-	(cc=0.394)	info on Rv1167c/-
Rv0254c/cobU	(cc=0.3911)	info on Rv0254c/cobU
Rv2147c/-	(cc=0.3906)	info on Rv2147c/-
Rv3545c/cyp125	(cc=0.3814)	info on Rv3545c/cyp125
Rv2038c/-	(cc=0.38)	info on Rv2038c/-
Rv2345/-	(cc=0.3752)	info on Rv2345/-

Correlation of Rv1530/adh with Rv0254c/cobU

Normalized LFCs for Rv1530/adh:
(description and provenance of datasets)

	Rv1530/adh	Rv0254c/cobU
Fe_supp_jason_reseq	-0.429	0.731
low_pH_jason_reseq	0.318	-0.37
NO_jason_reseq	0.173	-0.995
B6_jason_reseq	-1.638	-0.688
MHCII_jason_reseq	-0.594	-0.842
Isoniazid02	-0.509	-2.808
Rifampicin4	0.712	0.636
Ethambutol3	-0.496	-2.219
Meropenem3	-0.419	-0.526
Vancomycin16	-0.058	-0.515
Rv2680_day32	-0.921	0.338
H37Rv_KO_MarP	0.667	-0.145
hypoxia_3wks	0.0	-0.475
hypoxia_6wks	0.384	0.411
glycerol	0.541	0.807
cholesterol	0.141	0.558
AJ	1.365	0.434
Bibs02	-0.729	-0.136
Bibs02c	-0.409	-1.234
BL6	-0.033	0.446
BL6a	0.369	-0.809
BXD01	0.065	-1.084
BXD010	-0.033	-0.767
BXD011	0.264	-0.501
BXD03	1.111	-0.085
BXD04	0.0	-0.415
BXD05	1.058	-0.413
BXD06	0.249	-0.322
BXD07	0.258	-0.652
BXD08	-0.26	0.38
BXD09	0.534	-0.268
CAST	-0.38	-1.298
CCcont	0.18	0.36
DS01	-0.123	-0.861
DS02	-0.866	-1.363
DS04	-1.086	-1.727
DS0c	-0.947	0.077
GP01	-0.358	0.995
GP02	-0.934	-0.995
GP0c	0.908	-0.178
NOD	0.854	-0.13
NZO	0.413	0.399
PWK	-0.102	-0.257
H37Rv_KO_CtpC	0.956	-0.651
H37Rv_KO_CtpD	1.399	1.216
H37Rv_KO_Rv1272	1.299	0.117
H37Rv_KO_SugABC	1.981	0.663
H37Rv_KO_MbtN	0.235	-0.228
Trans05	-0.571	-0.636
macrophage_unactivated	1.376	0.183
IL1	0.552	0.234
Rapamycin	0.169	0.97
Tcell	0.091	0.391
GMCSF	0.491	1.249
IFNab	0.635	0.901
IFNg	0.561	0.665
IFNg_GMCSF1	-0.273	0.974
Rv1432_day32	-0.697	-0.334
Rv1565c_day32	0.431	0.278
secA2_input	1.13	0.726
delta_Rv3594	0.603	-0.063
delta_Rv3717	0.287	0.35
delta_Rv3811	-0.126	0.205
delta_Rv0954	0.809	0.451
PonA1	0.526	0.684
EccD1_KO	0.599	-0.635
EspI_KO	0.077	-1.577
PE35_KO	0.312	-0.68
PPE68_KO	0.086	-0.637
glycerol2	0.115	1.188
lignocerate	0.569	1.579
oleate	0.06	-0.079
phosphatidylcholine	0.521	0.962
acetate	0.924	2.071
glucAc	0.689	1.662
Rv0950ko	-0.706	0.88
Rv1096ko	-0.881	0.715
Rv3684ko	-0.413	0.327
delta_otsA_trehalose	0.621	0.065