TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv1526c/-:

update plot	correlation	link to info on gene
Rv1583c/-	(cc=0.7027)	info on Rv1583c/-
Rv1548c/PPE21	(cc=0.6703)	info on Rv1548c/PPE21
Rv1551/plsB1	(cc=0.6325)	info on Rv1551/plsB1
Rv1167c/-	(cc=0.5961)	info on Rv1167c/-
Rv3112/moaD1	(cc=0.5932)	info on Rv3112/moaD1
Rv3148/nuoD	(cc=0.5846)	info on Rv3148/nuoD
Rv2818c/-	(cc=0.5784)	info on Rv2818c/-
Rv2038c/-	(cc=0.5712)	info on Rv2038c/-
Rv1059/-	(cc=0.571)	info on Rv1059/-
Rv1529/fadD24	(cc=0.5687)	info on Rv1529/fadD24

Correlation of Rv1526c/- with Rv2038c/-

Normalized LFCs for Rv1526c/-:
(description and provenance of datasets)

	Rv1526c/-	Rv2038c/-
Fe_supp_jason_reseq	0.082	-1.699
low_pH_jason_reseq	0.043	-0.127
NO_jason_reseq	0.331	-0.465
B6_jason_reseq	-2.248	-2.64
MHCII_jason_reseq	-1.614	-0.977
Isoniazid02	0.047	0.115
Rifampicin4	-0.325	-0.149
Ethambutol3	-0.212	-0.067
Meropenem3	-0.165	-0.321
Vancomycin16	-0.133	0.21
Rv2680_day32	-0.548	-1.358
H37Rv_KO_MarP	1.37	0.207
hypoxia_3wks	-0.558	-0.183
hypoxia_6wks	0.0	1.462
glycerol	0.243	-1.252
cholesterol	-0.038	-1.217
AJ	0.225	-0.494
Bibs02	-0.415	-1.537
Bibs02c	0.344	-0.591
BL6	2.032	1.212
BL6a	1.277	0.106
BXD01	1.115	-0.074
BXD010	1.082	0.34
BXD011	2.02	0.888
BXD03	1.063	0.622
BXD04	0.426	0.612
BXD05	1.058	1.52
BXD06	0.967	0.438
BXD07	1.868	0.731
BXD08	0.575	0.849
BXD09	1.249	0.979
CAST	0.707	0.184
CCcont	1.423	0.764
DS01	0.633	-0.936
DS02	0.748	-1.575
DS04	0.402	-0.225
DS0c	-0.295	-0.251
GP01	0.727	1.204
GP02	1.017	0.544
GP0c	1.754	0.598
NOD	1.154	-0.404
NZO	0.1	0.306
PWK	-0.156	-0.627
H37Rv_KO_CtpC	1.462	0.087
H37Rv_KO_CtpD	1.973	1.034
H37Rv_KO_Rv1272	2.07	1.002
H37Rv_KO_SugABC	1.981	0.784
H37Rv_KO_MbtN	0.479	1.145
Trans05	1.657	2.398
macrophage_unactivated	0.71	-0.246
IL1	0.095	1.397
Rapamycin	0.648	-0.239
Tcell	0.909	0.544
GMCSF	0.594	0.38
IFNab	0.239	0.834
IFNg	1.056	0.738
IFNg_GMCSF1	0.05	0.93
Rv1432_day32	-0.87	-0.614
Rv1565c_day32	-0.291	0.096
secA2_input	-0.482	-0.504
delta_Rv3594	0.895	0.035
delta_Rv3717	0.029	-0.218
delta_Rv3811	1.17	0.034
delta_Rv0954	0.652	-0.864
PonA1	1.392	-2.363
EccD1_KO	0.835	0.914
EspI_KO	0.967	-0.257
PE35_KO	0.989	0.187
PPE68_KO	0.95	-0.678
glycerol2	0.376	0.607
lignocerate	1.333	1.538
oleate	-1.157	-1.418
phosphatidylcholine	0.758	0.531
acetate	1.403	1.998
glucAc	1.533	1.735
Rv0950ko	-0.265	-1.049
Rv1096ko	-0.407	0.0
Rv3684ko	-0.704	-0.727
delta_otsA_trehalose	1.158	0.087