TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv1377c/-:

update plot	correlation	link to info on gene
Rv0329c/-	(cc=0.4981)	info on Rv0329c/-
Rv0664/vapB8	(cc=0.4956)	info on Rv0664/vapB8
Rv2499c/-	(cc=0.4812)	info on Rv2499c/-
Rv2009/vapB15	(cc=0.478)	info on Rv2009/vapB15
Rv2802c/-	(cc=0.4693)	info on Rv2802c/-
Rv1192/-	(cc=0.458)	info on Rv1192/-
Rv1186c/-	(cc=0.4524)	info on Rv1186c/-
Rv1974/-	(cc=0.4448)	info on Rv1974/-
Rv1731/gabD2	(cc=0.4447)	info on Rv1731/gabD2
Rv2813/-	(cc=0.4369)	info on Rv2813/-

Correlation of Rv1377c/- with Rv0329c/-

Normalized LFCs for Rv1377c/-:
(description and provenance of datasets)

	Rv1377c/-	Rv0329c/-
Fe_supp_jason_reseq	1.35	0.379
low_pH_jason_reseq	-0.952	-0.134
NO_jason_reseq	0.042	-0.26
B6_jason_reseq	-0.018	-0.659
MHCII_jason_reseq	0.206	-0.895
Isoniazid02	0.658	0.338
Rifampicin4	0.81	0.07
Ethambutol3	0.209	0.618
Meropenem3	0.987	1.267
Vancomycin16	1.035	0.674
Rv2680_day32	0.142	0.263
H37Rv_KO_MarP	0.323	0.072
hypoxia_3wks	-0.574	-0.897
hypoxia_6wks	-0.819	-0.618
glycerol	0.496	1.233
cholesterol	0.857	0.093
AJ	0.032	0.684
Bibs02	0.617	0.368
Bibs02c	-0.462	0.192
BL6	-0.465	0.132
BL6a	0.0	-0.217
BXD01	0.335	0.038
BXD010	0.071	-1.189
BXD011	-0.185	-0.248
BXD03	0.278	-1.678
BXD04	-0.524	-0.942
BXD05	-0.5	-0.851
BXD06	0.083	-0.508
BXD07	0.14	-0.542
BXD08	0.281	-0.201
BXD09	-0.18	-0.351
CAST	0.554	1.093
CCcont	0.021	0.449
DS01	-0.481	0.185
DS02	0.734	-0.386
DS04	0.645	0.846
DS0c	0.903	0.837
GP01	0.576	0.45
GP02	-0.276	0.371
GP0c	0.632	0.324
NOD	1.84	0.325
NZO	0.879	1.37
PWK	0.122	0.419
H37Rv_KO_CtpC	-0.759	-1.598
H37Rv_KO_CtpD	-1.164	-0.523
H37Rv_KO_Rv1272	-1.011	-1.651
H37Rv_KO_SugABC	-0.543	0.629
H37Rv_KO_MbtN	-1.402	-0.201
Trans05	-0.243	-0.808
macrophage_unactivated	-0.439	0.041
IL1	0.492	-0.243
Rapamycin	0.479	-0.657
Tcell	0.345	-0.222
GMCSF	0.198	0.523
IFNab	0.414	-0.692
IFNg	0.257	-1.39
IFNg_GMCSF1	-0.176	1.166
Rv1432_day32	-0.437	-0.408
Rv1565c_day32	-0.34	0.676
secA2_input	0.163	-0.252
delta_Rv3594	0.502	-1.234
delta_Rv3717	0.098	-1.128
delta_Rv3811	0.138	-1.077
delta_Rv0954	0.928	-0.775
PonA1	1.019	0.471
EccD1_KO	0.76	-0.24
EspI_KO	-0.627	-0.299
PE35_KO	0.35	0.26
PPE68_KO	0.195	-0.445
glycerol2	0.326	1.197
lignocerate	0.878	1.97
oleate	-0.535	-0.625
phosphatidylcholine	1.2	1.234
acetate	1.406	1.684
glucAc	1.266	1.611
Rv0950ko	1.381	0.832
Rv1096ko	0.811	0.525
Rv3684ko	0.881	0.648
delta_otsA_trehalose	0.974	0.769