TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv1169c/lipX:

update plot	correlation	link to info on gene
Rv0940c/-	(cc=0.5799)	info on Rv0940c/-
Rv2639c/-	(cc=0.567)	info on Rv2639c/-
Rv0868c/moaD2	(cc=0.5571)	info on Rv0868c/moaD2
Rv1498c/-	(cc=0.5267)	info on Rv1498c/-
Rv0934/pstS1	(cc=0.5252)	info on Rv0934/pstS1
Rv2947c/pks15	(cc=0.5197)	info on Rv2947c/pks15
Rv2501c/accA1	(cc=0.5133)	info on Rv2501c/accA1
Rv0932c/pstS2	(cc=0.5118)	info on Rv0932c/pstS2
Rv0115/hddA	(cc=0.5022)	info on Rv0115/hddA
Rv0399c/lpqK	(cc=0.4945)	info on Rv0399c/lpqK

Correlation of Rv1169c/lipX with Rv2501c/accA1

Normalized LFCs for Rv1169c/lipX:
(description and provenance of datasets)

	Rv1169c/lipX	Rv2501c/accA1
Fe_supp_jason_reseq	0.079	-0.052
low_pH_jason_reseq	0.321	-0.622
NO_jason_reseq	0.701	0.168
B6_jason_reseq	-0.978	-1.11
MHCII_jason_reseq	-0.759	-0.323
Isoniazid02	-3.566	-1.455
Rifampicin4	0.458	1.045
Ethambutol3	-3.227	-0.814
Meropenem3	-4.373	-0.801
Vancomycin16	-1.366	-0.39
Rv2680_day32	-0.773	-1.015
H37Rv_KO_MarP	0.869	0.178
hypoxia_3wks	1.619	-0.478
hypoxia_6wks	1.806	-0.251
glycerol	-1.953	0.256
cholesterol	0.162	0.597
AJ	1.314	0.904
Bibs02	0.73	0.58
Bibs02c	-0.568	0.202
BL6	-0.365	0.651
BL6a	0.469	1.187
BXD01	0.429	0.38
BXD010	0.353	0.928
BXD011	-0.065	0.834
BXD03	0.393	1.409
BXD04	0.843	2.038
BXD05	0.736	1.385
BXD06	0.862	0.775
BXD07	-0.011	0.256
BXD08	-0.744	0.169
BXD09	1.031	1.018
CAST	-0.098	-0.078
CCcont	-0.093	1.107
DS01	0.0	-0.08
DS02	0.243	0.58
DS04	0.916	0.843
DS0c	-0.357	-0.313
GP01	-0.207	0.182
GP02	1.683	1.155
GP0c	-0.19	0.0
NOD	0.443	0.926
NZO	1.441	0.532
PWK	1.081	0.249
H37Rv_KO_CtpC	0.34	1.309
H37Rv_KO_CtpD	-1.93	1.664
H37Rv_KO_Rv1272	0.799	0.179
H37Rv_KO_SugABC	-1.493	-0.751
H37Rv_KO_MbtN	-0.948	-0.072
Trans05	1.852	0.166
macrophage_unactivated	0.18	0.915
IL1	0.11	0.451
Rapamycin	-0.721	0.654
Tcell	0.762	-0.228
GMCSF	-1.03	0.911
IFNab	-0.94	0.203
IFNg	0.227	0.238
IFNg_GMCSF1	-0.27	0.0
Rv1432_day32	0.18	1.025
Rv1565c_day32	-4.364	-1.549
secA2_input	0.515	0.831
delta_Rv3594	-0.762	-0.667
delta_Rv3717	-0.863	-0.347
delta_Rv3811	-1.145	-0.354
delta_Rv0954	-2.038	-0.406
PonA1	-1.794	-0.362
EccD1_KO	-0.135	-0.595
EspI_KO	-0.878	-0.425
PE35_KO	0.808	0.16
PPE68_KO	0.605	-0.278
glycerol2	0.611	-0.045
lignocerate	0.095	0.407
oleate	-0.098	-0.138
phosphatidylcholine	0.618	0.324
acetate	0.454	0.384
glucAc	-0.126	0.267
Rv0950ko	-0.154	0.356
Rv1096ko	-0.953	0.914
Rv3684ko	-2.053	0.098
delta_otsA_trehalose	-0.471	0.238