TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv1081c/-:

update plot	correlation	link to info on gene
Rv0537c/-	(cc=0.5682)	info on Rv0537c/-
Rv3067/-	(cc=0.5503)	info on Rv3067/-
Rv0062/celA1	(cc=0.5082)	info on Rv0062/celA1
Rv0538/-	(cc=0.4837)	info on Rv0538/-
Rv1458c/-	(cc=0.4693)	info on Rv1458c/-
Rv2908c/-	(cc=0.4638)	info on Rv2908c/-
Rv2375/-	(cc=0.4553)	info on Rv2375/-
Rv3916c/-	(cc=0.4543)	info on Rv3916c/-
Rv1845c/blaR	(cc=0.4414)	info on Rv1845c/blaR
Rv2926c/-	(cc=0.4261)	info on Rv2926c/-

Correlation of Rv1081c/- with Rv0062/celA1

Normalized LFCs for Rv1081c/-:
(description and provenance of datasets)

	Rv1081c/-	Rv0062/celA1
Fe_supp_jason_reseq	0.415	-0.707
low_pH_jason_reseq	0.0	-0.795
NO_jason_reseq	0.0	0.05
B6_jason_reseq	0.0	-0.458
MHCII_jason_reseq	0.0	-0.873
Isoniazid02	-0.65	-0.236
Rifampicin4	-0.872	0.791
Ethambutol3	0.22	0.46
Meropenem3	-0.386	-1.385
Vancomycin16	-1.186	-0.602
Rv2680_day32	0.095	-0.151
H37Rv_KO_MarP	2.237	4.058
hypoxia_3wks	0.0	-0.267
hypoxia_6wks	0.0	-0.098
glycerol	0.0	0.407
cholesterol	0.398	0.238
AJ	0.0	-0.452
Bibs02	0.0	0.725
Bibs02c	0.0	-0.111
BL6	0.125	0.628
BL6a	0.198	0.235
BXD01	0.13	0.206
BXD010	0.0	0.349
BXD011	0.54	-0.248
BXD03	0.0	0.169
BXD04	0.124	0.714
BXD05	0.473	-0.192
BXD06	0.366	-0.411
BXD07	0.0	0.05
BXD08	0.0	0.392
BXD09	0.494	0.194
CAST	0.0	-0.349
CCcont	0.285	0.592
DS01	0.0	0.643
DS02	0.0	1.227
DS04	0.37	1.706
DS0c	0.0	0.49
GP01	0.0	-0.534
GP02	0.0	0.137
GP0c	0.0	-0.565
NOD	0.0	-0.438
NZO	0.0	-0.634
PWK	0.0	-0.166
H37Rv_KO_CtpC	0.798	0.161
H37Rv_KO_CtpD	0.0	0.855
H37Rv_KO_Rv1272	0.0	0.195
H37Rv_KO_SugABC	0.0	0.432
H37Rv_KO_MbtN	0.633	0.214
Trans05	0.0	0.385
macrophage_unactivated	0.0	0.271
IL1	0.0	-0.303
Rapamycin	0.0	-0.249
Tcell	0.0	0.127
GMCSF	0.0	0.325
IFNab	0.0	0.148
IFNg	0.0	-0.989
IFNg_GMCSF1	0.0	-0.126
Rv1432_day32	0.0	0.27
Rv1565c_day32	0.0	-0.246
secA2_input	0.739	-0.661
delta_Rv3594	-1.205	-1.103
delta_Rv3717	-0.555	-0.593
delta_Rv3811	-0.369	-1.191
delta_Rv0954	-0.207	-0.846
PonA1	0.389	-0.563
EccD1_KO	0.286	-0.582
EspI_KO	-0.55	-0.887
PE35_KO	0.0	-0.49
PPE68_KO	-0.298	-0.819
glycerol2	0.0	0.544
lignocerate	0.0	0.708
oleate	0.0	0.061
phosphatidylcholine	0.0	0.588
acetate	0.0	0.575
glucAc	0.0	0.777
Rv0950ko	0.0	0.564
Rv1096ko	-0.302	0.154
Rv3684ko	1.117	0.0
delta_otsA_trehalose	-1.098	-0.533