TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv0891c/-:

update plot	correlation	link to info on gene
Rv0691c/-	(cc=0.4676)	info on Rv0691c/-
Rv0669c/-	(cc=0.4534)	info on Rv0669c/-
Rv3386/-	(cc=0.4383)	info on Rv3386/-
Rv3844/-	(cc=0.4341)	info on Rv3844/-
Rv3529c/-	(cc=0.4236)	info on Rv3529c/-
Rv1509/-	(cc=0.4143)	info on Rv1509/-
Rv0920c/-	(cc=0.4107)	info on Rv0920c/-
Rv2408/PE24	(cc=0.4088)	info on Rv2408/PE24
Rv0886/fprB	(cc=0.4013)	info on Rv0886/fprB
Rv3348/-	(cc=0.3991)	info on Rv3348/-

Correlation of Rv0891c/- with Rv0669c/-

Normalized LFCs for Rv0891c/-:
(description and provenance of datasets)

	Rv0891c/-	Rv0669c/-
Fe_supp_jason_reseq	1.124	-0.156
low_pH_jason_reseq	-0.427	-0.582
NO_jason_reseq	-0.037	0.039
B6_jason_reseq	0.924	0.331
MHCII_jason_reseq	0.531	0.163
Isoniazid02	-0.215	0.247
Rifampicin4	0.187	0.0
Ethambutol3	0.668	1.07
Meropenem3	-0.201	0.492
Vancomycin16	0.313	-0.019
Rv2680_day32	-0.559	0.483
H37Rv_KO_MarP	1.398	0.344
hypoxia_3wks	-0.231	-0.231
hypoxia_6wks	0.2	0.092
glycerol	-0.312	0.445
cholesterol	2.321	3.252
AJ	-0.232	0.279
Bibs02	-0.064	0.317
Bibs02c	0.282	-0.03
BL6	0.414	-0.03
BL6a	0.646	-0.135
BXD01	0.418	0.134
BXD010	0.662	-0.056
BXD011	0.447	0.12
BXD03	1.007	0.318
BXD04	0.397	0.164
BXD05	0.928	0.121
BXD06	0.475	0.155
BXD07	0.693	0.013
BXD08	0.721	0.209
BXD09	0.673	-0.161
CAST	0.377	0.237
CCcont	0.574	-0.276
DS01	-0.185	0.212
DS02	0.331	0.386
DS04	0.013	0.513
DS0c	-0.387	0.138
GP01	0.121	0.31
GP02	0.117	-0.395
GP0c	-0.525	-0.135
NOD	1.359	0.251
NZO	0.244	0.247
PWK	-0.139	0.269
H37Rv_KO_CtpC	0.266	-0.127
H37Rv_KO_CtpD	0.671	0.199
H37Rv_KO_Rv1272	0.129	0.534
H37Rv_KO_SugABC	-1.442	1.096
H37Rv_KO_MbtN	-0.416	-0.03
Trans05	-0.191	-0.076
macrophage_unactivated	-0.183	-0.174
IL1	0.237	-0.486
Rapamycin	0.114	-0.718
Tcell	0.544	0.042
GMCSF	-0.615	-0.09
IFNab	-0.039	-0.405
IFNg	0.682	-0.521
IFNg_GMCSF1	-0.041	-0.493
Rv1432_day32	0.559	0.183
Rv1565c_day32	0.788	-0.22
secA2_input	-1.207	-1.021
delta_Rv3594	0.575	-0.32
delta_Rv3717	-0.853	-0.322
delta_Rv3811	-0.407	-0.103
delta_Rv0954	-0.092	-0.91
PonA1	-0.501	-0.372
EccD1_KO	-0.474	0.385
EspI_KO	0.69	0.642
PE35_KO	0.592	0.076
PPE68_KO	0.518	0.163
glycerol2	0.824	0.815
lignocerate	0.981	0.919
oleate	0.776	0.333
phosphatidylcholine	0.964	0.944
acetate	0.409	0.532
glucAc	0.438	0.573
Rv0950ko	-0.208	0.265
Rv1096ko	0.223	0.066
Rv3684ko	-0.255	0.265
delta_otsA_trehalose	-0.979	-1.542