TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv0891c/-:

update plot	correlation	link to info on gene
Rv0691c/-	(cc=0.4676)	info on Rv0691c/-
Rv0669c/-	(cc=0.4534)	info on Rv0669c/-
Rv3386/-	(cc=0.4383)	info on Rv3386/-
Rv3844/-	(cc=0.4341)	info on Rv3844/-
Rv3529c/-	(cc=0.4236)	info on Rv3529c/-
Rv1509/-	(cc=0.4143)	info on Rv1509/-
Rv0920c/-	(cc=0.4107)	info on Rv0920c/-
Rv2408/PE24	(cc=0.4088)	info on Rv2408/PE24
Rv0886/fprB	(cc=0.4013)	info on Rv0886/fprB
Rv3348/-	(cc=0.3991)	info on Rv3348/-

Correlation of Rv0891c/- with Rv0691c/-

Normalized LFCs for Rv0891c/-:
(description and provenance of datasets)

	Rv0891c/-	Rv0691c/-
Fe_supp_jason_reseq	1.124	0.963
low_pH_jason_reseq	-0.427	0.714
NO_jason_reseq	-0.037	0.974
B6_jason_reseq	0.924	0.013
MHCII_jason_reseq	0.531	0.381
Isoniazid02	-0.215	0.239
Rifampicin4	0.187	-0.39
Ethambutol3	0.668	1.589
Meropenem3	-0.201	-0.014
Vancomycin16	0.313	-0.135
Rv2680_day32	-0.559	-0.411
H37Rv_KO_MarP	1.398	0.629
hypoxia_3wks	-0.231	0.562
hypoxia_6wks	0.2	-0.311
glycerol	-0.312	-0.919
cholesterol	2.321	1.077
AJ	-0.232	-0.698
Bibs02	-0.064	-0.423
Bibs02c	0.282	0.214
BL6	0.414	-0.242
BL6a	0.646	0.486
BXD01	0.418	0.933
BXD010	0.662	-0.727
BXD011	0.447	0.266
BXD03	1.007	0.653
BXD04	0.397	1.039
BXD05	0.928	0.33
BXD06	0.475	0.278
BXD07	0.693	0.976
BXD08	0.721	0.435
BXD09	0.673	0.491
CAST	0.377	0.087
CCcont	0.574	0.253
DS01	-0.185	0.323
DS02	0.331	0.52
DS04	0.013	-0.305
DS0c	-0.387	0.222
GP01	0.121	0.88
GP02	0.117	-1.043
GP0c	-0.525	-0.288
NOD	1.359	-0.236
NZO	0.244	-0.296
PWK	-0.139	-0.189
H37Rv_KO_CtpC	0.266	0.12
H37Rv_KO_CtpD	0.671	0.569
H37Rv_KO_Rv1272	0.129	-0.021
H37Rv_KO_SugABC	-1.442	-0.589
H37Rv_KO_MbtN	-0.416	1.129
Trans05	-0.191	-1.029
macrophage_unactivated	-0.183	0.597
IL1	0.237	0.05
Rapamycin	0.114	-0.083
Tcell	0.544	0.029
GMCSF	-0.615	-0.264
IFNab	-0.039	-0.447
IFNg	0.682	-0.345
IFNg_GMCSF1	-0.041	0.028
Rv1432_day32	0.559	-0.302
Rv1565c_day32	0.788	0.439
secA2_input	-1.207	-0.157
delta_Rv3594	0.575	-0.792
delta_Rv3717	-0.853	-1.861
delta_Rv3811	-0.407	-1.209
delta_Rv0954	-0.092	-0.774
PonA1	-0.501	-0.444
EccD1_KO	-0.474	0.625
EspI_KO	0.69	1.426
PE35_KO	0.592	1.683
PPE68_KO	0.518	1.03
glycerol2	0.824	0.486
lignocerate	0.981	-0.026
oleate	0.776	0.615
phosphatidylcholine	0.964	0.52
acetate	0.409	-0.351
glucAc	0.438	-0.473
Rv0950ko	-0.208	-0.024
Rv1096ko	0.223	-0.317
Rv3684ko	-0.255	0.321
delta_otsA_trehalose	-0.979	-2.952