TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv0826/-:

update plot	correlation	link to info on gene
Rv0654/-	(cc=0.4795)	info on Rv0654/-
Rv0364/-	(cc=0.4478)	info on Rv0364/-
Rv3575c/-	(cc=0.4461)	info on Rv3575c/-
Rv0402c/mmpL1	(cc=0.4363)	info on Rv0402c/mmpL1
Rv1546/-	(cc=0.4303)	info on Rv1546/-
Rv3837c/-	(cc=0.4262)	info on Rv3837c/-
Rv2187/fadD15	(cc=0.4131)	info on Rv2187/fadD15
Rv0825c/-	(cc=0.4126)	info on Rv0825c/-
Rv0645c/mmaA1	(cc=0.4096)	info on Rv0645c/mmaA1
Rv0134/ephF	(cc=0.4074)	info on Rv0134/ephF

Correlation of Rv0826/- with Rv2187/fadD15

Normalized LFCs for Rv0826/-:
(description and provenance of datasets)

	Rv0826/-	Rv2187/fadD15
Fe_supp_jason_reseq	-0.48	-0.534
low_pH_jason_reseq	-1.4	-0.303
NO_jason_reseq	0.845	1.124
B6_jason_reseq	0.127	0.165
MHCII_jason_reseq	0.272	-0.597
Isoniazid02	0.013	0.349
Rifampicin4	-0.168	0.16
Ethambutol3	-0.011	-0.011
Meropenem3	0.061	-0.023
Vancomycin16	-0.154	-0.406
Rv2680_day32	1.381	0.836
H37Rv_KO_MarP	0.161	0.526
hypoxia_3wks	0.0	0.132
hypoxia_6wks	0.038	0.069
glycerol	-0.696	-0.566
cholesterol	-0.232	-0.14
AJ	0.35	0.748
Bibs02	0.339	-0.132
Bibs02c	-0.118	-0.162
BL6	0.35	-0.034
BL6a	-0.267	0.261
BXD01	0.556	0.445
BXD010	0.217	0.405
BXD011	-0.054	0.521
BXD03	-0.116	0.103
BXD04	0.293	0.201
BXD05	0.171	0.775
BXD06	0.29	0.581
BXD07	-0.027	0.301
BXD08	0.383	0.632
BXD09	-0.039	0.407
CAST	0.075	1.44
CCcont	-0.029	-0.279
DS01	0.222	-0.356
DS02	0.348	-0.169
DS04	0.631	0.669
DS0c	-0.104	0.093
GP01	0.061	0.286
GP02	0.156	0.328
GP0c	-0.147	0.151
NOD	-0.037	0.527
NZO	0.538	0.517
PWK	0.585	0.877
H37Rv_KO_CtpC	0.112	-0.173
H37Rv_KO_CtpD	-0.155	-0.006
H37Rv_KO_Rv1272	0.09	-0.324
H37Rv_KO_SugABC	0.121	0.547
H37Rv_KO_MbtN	0.803	-0.046
Trans05	0.704	1.157
macrophage_unactivated	0.388	0.161
IL1	-0.071	0.19
Rapamycin	-0.316	0.27
Tcell	0.3	0.384
GMCSF	0.335	0.185
IFNab	-0.532	-0.478
IFNg	0.126	0.444
IFNg_GMCSF1	0.902	0.179
Rv1432_day32	1.446	1.572
Rv1565c_day32	0.074	-0.625
secA2_input	0.404	-0.376
delta_Rv3594	0.119	0.355
delta_Rv3717	0.554	0.456
delta_Rv3811	0.306	0.274
delta_Rv0954	0.328	-0.477
PonA1	-0.304	-0.417
EccD1_KO	-0.257	0.691
EspI_KO	0.536	-0.068
PE35_KO	-0.615	0.633
PPE68_KO	-0.656	0.25
glycerol2	-0.015	0.595
lignocerate	0.179	0.598
oleate	0.213	0.872
phosphatidylcholine	0.262	0.626
acetate	-0.025	-0.033
glucAc	-0.139	0.868
Rv0950ko	0.51	-0.308
Rv1096ko	0.73	0.048
Rv3684ko	1.035	0.262
delta_otsA_trehalose	-0.544	-0.626