TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv0752c/fadE9:

update plot	correlation	link to info on gene
Rv0727c/fucA	(cc=0.4059)	info on Rv0727c/fucA
Rv3180c/-	(cc=0.4049)	info on Rv3180c/-
Rv2219/-	(cc=0.3896)	info on Rv2219/-
Rv0278c/PE_PGRS3	(cc=0.3828)	info on Rv0278c/PE_PGRS3
Rv1352/-	(cc=0.3705)	info on Rv1352/-
Rv3653/PE_PGRS61	(cc=0.3646)	info on Rv3653/PE_PGRS61
Rv2850c/-	(cc=0.3588)	info on Rv2850c/-
Rv1087/PE_PGRS21	(cc=0.3403)	info on Rv1087/PE_PGRS21
Rv0613c/-	(cc=0.3402)	info on Rv0613c/-
Rv0794c/-	(cc=0.3388)	info on Rv0794c/-

Correlation of Rv0752c/fadE9 with Rv3653/PE_PGRS61

Normalized LFCs for Rv0752c/fadE9:
(description and provenance of datasets)

	Rv0752c/fadE9	Rv3653/PE_PGRS61
Fe_supp_jason_reseq	-0.129	-1.751
low_pH_jason_reseq	-0.323	0.796
NO_jason_reseq	0.053	-1.376
B6_jason_reseq	0.494	-0.998
MHCII_jason_reseq	1.211	0.838
Isoniazid02	-0.095	-0.097
Rifampicin4	0.33	0.653
Ethambutol3	-0.119	-0.505
Meropenem3	0.328	-0.208
Vancomycin16	0.546	0.0
Rv2680_day32	0.259	0.131
H37Rv_KO_MarP	0.502	-0.054
hypoxia_3wks	0.104	-0.243
hypoxia_6wks	0.267	-1.038
glycerol	1.295	1.796
cholesterol	0.361	0.657
AJ	0.919	2.123
Bibs02	0.775	0.207
Bibs02c	0.0	0.949
BL6	0.23	-1.513
BL6a	0.154	-0.251
BXD01	0.304	1.001
BXD010	-0.164	-1.676
BXD011	0.075	-0.559
BXD03	0.661	-0.041
BXD04	0.944	-1.184
BXD05	-0.821	-1.101
BXD06	-0.298	-1.493
BXD07	0.641	-0.809
BXD08	1.5	-1.274
BXD09	0.027	-0.75
CAST	-0.095	-0.537
CCcont	0.89	-1.67
DS01	0.394	1.205
DS02	0.0	1.407
DS04	1.346	1.376
DS0c	0.248	-0.066
GP01	0.577	1.378
GP02	1.051	-0.134
GP0c	0.847	1.48
NOD	-0.864	0.428
NZO	0.367	-0.54
PWK	-0.163	1.0
H37Rv_KO_CtpC	-0.991	-1.226
H37Rv_KO_CtpD	0.355	0.691
H37Rv_KO_Rv1272	1.131	-0.619
H37Rv_KO_SugABC	-0.502	-1.108
H37Rv_KO_MbtN	-0.49	-1.067
Trans05	0.907	2.522
macrophage_unactivated	0.227	-3.857
IL1	-0.795	-4.239
Rapamycin	1.004	-2.056
Tcell	0.0	-3.679
GMCSF	-0.787	-4.077
IFNab	-0.469	-2.899
IFNg	0.767	-0.345
IFNg_GMCSF1	-1.329	-2.316
Rv1432_day32	-0.338	0.85
Rv1565c_day32	0.382	-1.15
secA2_input	0.211	-0.568
delta_Rv3594	1.45	0.696
delta_Rv3717	0.123	1.131
delta_Rv3811	0.315	-0.098
delta_Rv0954	0.216	-2.367
PonA1	-0.675	-0.219
EccD1_KO	1.316	-0.585
EspI_KO	-0.297	-0.933
PE35_KO	0.0	0.878
PPE68_KO	0.544	-0.723
glycerol2	0.092	1.261
lignocerate	1.218	0.673
oleate	0.508	1.55
phosphatidylcholine	0.755	0.95
acetate	0.818	1.32
glucAc	0.938	0.096
Rv0950ko	-0.519	1.939
Rv1096ko	0.464	1.475
Rv3684ko	0.596	-0.344
delta_otsA_trehalose	0.214	0.0