TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv0752c/fadE9:

update plot	correlation	link to info on gene
Rv0727c/fucA	(cc=0.4059)	info on Rv0727c/fucA
Rv3180c/-	(cc=0.4049)	info on Rv3180c/-
Rv2219/-	(cc=0.3896)	info on Rv2219/-
Rv0278c/PE_PGRS3	(cc=0.3828)	info on Rv0278c/PE_PGRS3
Rv1352/-	(cc=0.3705)	info on Rv1352/-
Rv3653/PE_PGRS61	(cc=0.3646)	info on Rv3653/PE_PGRS61
Rv2850c/-	(cc=0.3588)	info on Rv2850c/-
Rv1087/PE_PGRS21	(cc=0.3403)	info on Rv1087/PE_PGRS21
Rv0613c/-	(cc=0.3402)	info on Rv0613c/-
Rv0794c/-	(cc=0.3388)	info on Rv0794c/-

Correlation of Rv0752c/fadE9 with Rv0727c/fucA

Normalized LFCs for Rv0752c/fadE9:
(description and provenance of datasets)

	Rv0752c/fadE9	Rv0727c/fucA
Fe_supp_jason_reseq	-0.129	-0.758
low_pH_jason_reseq	-0.323	-1.317
NO_jason_reseq	0.053	-0.278
B6_jason_reseq	0.494	-0.494
MHCII_jason_reseq	1.211	-0.013
Isoniazid02	-0.095	0.18
Rifampicin4	0.33	0.858
Ethambutol3	-0.119	0.546
Meropenem3	0.328	-0.02
Vancomycin16	0.546	0.35
Rv2680_day32	0.259	0.879
H37Rv_KO_MarP	0.502	0.161
hypoxia_3wks	0.104	-0.359
hypoxia_6wks	0.267	-0.975
glycerol	1.295	0.635
cholesterol	0.361	0.237
AJ	0.919	0.802
Bibs02	0.775	1.245
Bibs02c	0.0	1.047
BL6	0.23	-0.452
BL6a	0.154	0.851
BXD01	0.304	0.908
BXD010	-0.164	-0.097
BXD011	0.075	-0.048
BXD03	0.661	-0.157
BXD04	0.944	0.937
BXD05	-0.821	0.435
BXD06	-0.298	0.431
BXD07	0.641	0.538
BXD08	1.5	1.181
BXD09	0.027	0.043
CAST	-0.095	-0.397
CCcont	0.89	-0.028
DS01	0.394	0.732
DS02	0.0	0.761
DS04	1.346	1.549
DS0c	0.248	1.197
GP01	0.577	0.545
GP02	1.051	0.855
GP0c	0.847	0.483
NOD	-0.864	-0.231
NZO	0.367	0.545
PWK	-0.163	-0.024
H37Rv_KO_CtpC	-0.991	0.481
H37Rv_KO_CtpD	0.355	0.363
H37Rv_KO_Rv1272	1.131	0.512
H37Rv_KO_SugABC	-0.502	-1.504
H37Rv_KO_MbtN	-0.49	-1.202
Trans05	0.907	1.105
macrophage_unactivated	0.227	1.55
IL1	-0.795	0.314
Rapamycin	1.004	-0.055
Tcell	0.0	1.013
GMCSF	-0.787	-0.38
IFNab	-0.469	-0.435
IFNg	0.767	-0.903
IFNg_GMCSF1	-1.329	-0.484
Rv1432_day32	-0.338	0.219
Rv1565c_day32	0.382	0.564
secA2_input	0.211	-0.714
delta_Rv3594	1.45	0.236
delta_Rv3717	0.123	-0.23
delta_Rv3811	0.315	-1.017
delta_Rv0954	0.216	0.743
PonA1	-0.675	0.107
EccD1_KO	1.316	0.444
EspI_KO	-0.297	-0.137
PE35_KO	0.0	-0.344
PPE68_KO	0.544	-0.579
glycerol2	0.092	0.481
lignocerate	1.218	0.699
oleate	0.508	0.845
phosphatidylcholine	0.755	0.92
acetate	0.818	0.7
glucAc	0.938	0.616
Rv0950ko	-0.519	-0.063
Rv1096ko	0.464	0.332
Rv3684ko	0.596	0.514
delta_otsA_trehalose	0.214	0.166