TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv0649/fabD2:

update plot	correlation	link to info on gene
Rv1087/PE_PGRS21	(cc=0.7114)	info on Rv1087/PE_PGRS21
Rv3897c/-	(cc=0.7073)	info on Rv3897c/-
Rv0278c/PE_PGRS3	(cc=0.6841)	info on Rv0278c/PE_PGRS3
Rv0297/PE_PGRS5	(cc=0.67)	info on Rv0297/PE_PGRS5
Rv1818c/PE_PGRS33	(cc=0.6317)	info on Rv1818c/PE_PGRS33
Rv1755c/plcD	(cc=0.6279)	info on Rv1755c/plcD
Rv3344c/PE_PGRS49	(cc=0.6244)	info on Rv3344c/PE_PGRS49
Rv3345c/PE_PGRS50	(cc=0.5911)	info on Rv3345c/PE_PGRS50
Rv3653/PE_PGRS61	(cc=0.5774)	info on Rv3653/PE_PGRS61
Rv1160/mutT2	(cc=0.5714)	info on Rv1160/mutT2

Correlation of Rv0649/fabD2 with Rv1755c/plcD

Normalized LFCs for Rv0649/fabD2:
(description and provenance of datasets)

	Rv0649/fabD2	Rv1755c/plcD
Fe_supp_jason_reseq	-1.773	0.748
low_pH_jason_reseq	-2.946	-0.607
NO_jason_reseq	-2.444	-0.953
B6_jason_reseq	-0.889	0.322
MHCII_jason_reseq	0.58	-0.257
Isoniazid02	3.067	0.073
Rifampicin4	0.772	0.035
Ethambutol3	1.058	2.4
Meropenem3	0.952	-0.109
Vancomycin16	-0.135	-0.138
Rv2680_day32	2.793	0.476
H37Rv_KO_MarP	-0.865	-0.138
hypoxia_3wks	-2.588	-0.77
hypoxia_6wks	-2.658	-0.403
glycerol	1.837	-0.127
cholesterol	1.356	1.135
AJ	0.647	-0.304
Bibs02	3.449	0.404
Bibs02c	1.904	0.355
BL6	-1.637	0.604
BL6a	-0.27	-0.26
BXD01	0.929	0.0
BXD010	-0.056	-0.081
BXD011	-0.745	0.402
BXD03	0.639	0.487
BXD04	-0.11	0.498
BXD05	-0.947	0.598
BXD06	-1.182	0.0
BXD07	-0.617	-0.182
BXD08	-1.113	1.081
BXD09	-0.58	-0.512
CAST	0.926	0.137
CCcont	0.236	0.663
DS01	-0.44	-0.861
DS02	1.356	0.129
DS04	0.082	0.523
DS0c	-0.094	-0.44
GP01	1.694	2.688
GP02	1.051	0.92
GP0c	0.465	2.61
NOD	0.272	0.133
NZO	-0.824	-0.907
PWK	-1.38	-0.55
H37Rv_KO_CtpC	-1.522	0.275
H37Rv_KO_CtpD	-0.65	0.215
H37Rv_KO_Rv1272	0.371	0.163
H37Rv_KO_SugABC	-0.783	-0.13
H37Rv_KO_MbtN	0.084	2.448
Trans05	-0.21	0.221
macrophage_unactivated	-1.626	-0.398
IL1	-4.494	-1.474
Rapamycin	-4.342	-1.034
Tcell	-2.023	-1.619
GMCSF	-1.946	-1.096
IFNab	-5.629	-1.769
IFNg	-4.049	-1.563
IFNg_GMCSF1	-1.951	-2.13
Rv1432_day32	1.442	0.0
Rv1565c_day32	1.29	1.204
secA2_input	2.204	0.116
delta_Rv3594	0.367	0.122
delta_Rv3717	0.388	-0.405
delta_Rv3811	-1.13	-0.126
delta_Rv0954	-2.087	-1.043
PonA1	-0.559	-0.098
EccD1_KO	1.079	0.0
EspI_KO	1.586	0.0
PE35_KO	-0.718	0.0
PPE68_KO	-1.357	0.0
glycerol2	1.684	1.659
lignocerate	2.681	2.267
oleate	0.829	-0.196
phosphatidylcholine	1.594	2.027
acetate	3.812	1.872
glucAc	3.156	2.166
Rv0950ko	0.154	1.037
Rv1096ko	1.852	0.766
Rv3684ko	1.156	0.675
delta_otsA_trehalose	0.329	-1.146