TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv0592/mce2D:

update plot	correlation	link to info on gene
Rv3839/-	(cc=0.6059)	info on Rv3839/-
Rv0551c/fadD8	(cc=0.5984)	info on Rv0551c/fadD8
Rv0303/-	(cc=0.5553)	info on Rv0303/-
Rv3294c/-	(cc=0.5103)	info on Rv3294c/-
Rv1761c/-	(cc=0.5029)	info on Rv1761c/-
Rv3714c/-	(cc=0.4955)	info on Rv3714c/-
Rv3363c/-	(cc=0.4948)	info on Rv3363c/-
Rv0443/-	(cc=0.4587)	info on Rv0443/-
Rv3532/PPE61	(cc=0.4437)	info on Rv3532/PPE61
Rv1262c/-	(cc=0.4415)	info on Rv1262c/-

Correlation of Rv0592/mce2D with Rv3532/PPE61

Normalized LFCs for Rv0592/mce2D:
(description and provenance of datasets)

	Rv0592/mce2D	Rv3532/PPE61
Fe_supp_jason_reseq	0.622	-0.058
low_pH_jason_reseq	-0.049	-0.79
NO_jason_reseq	0.144	-0.194
B6_jason_reseq	0.552	0.706
MHCII_jason_reseq	0.342	0.622
Isoniazid02	0.06	0.501
Rifampicin4	-0.68	0.019
Ethambutol3	-0.43	0.798
Meropenem3	0.497	0.187
Vancomycin16	0.109	0.204
Rv2680_day32	-0.357	-0.116
H37Rv_KO_MarP	-0.135	0.203
hypoxia_3wks	-0.124	0.096
hypoxia_6wks	0.217	-0.129
glycerol	-0.298	0.334
cholesterol	-0.358	0.284
AJ	0.299	0.05
Bibs02	0.323	0.313
Bibs02c	0.488	0.371
BL6	0.835	0.12
BL6a	0.08	-0.014
BXD01	0.599	-0.209
BXD010	0.212	-0.409
BXD011	-0.054	0.005
BXD03	0.56	0.054
BXD04	0.261	-0.004
BXD05	0.072	0.371
BXD06	-0.134	-0.348
BXD07	0.127	-0.241
BXD08	0.171	-0.537
BXD09	-0.142	-0.257
CAST	0.889	0.452
CCcont	-0.173	-0.011
DS01	0.577	0.435
DS02	0.227	0.317
DS04	0.943	0.357
DS0c	0.732	0.731
GP01	0.521	0.479
GP02	0.055	0.504
GP0c	-0.255	-0.254
NOD	0.473	0.049
NZO	0.257	0.238
PWK	0.347	0.267
H37Rv_KO_CtpC	0.517	0.344
H37Rv_KO_CtpD	0.525	0.176
H37Rv_KO_Rv1272	-0.122	0.169
H37Rv_KO_SugABC	-1.55	0.239
H37Rv_KO_MbtN	-0.273	-0.361
Trans05	-0.716	-0.31
macrophage_unactivated	0.48	-0.417
IL1	-0.122	-0.427
Rapamycin	0.239	-0.282
Tcell	0.375	-0.156
GMCSF	0.401	-0.259
IFNab	-0.06	0.203
IFNg	0.259	-0.086
IFNg_GMCSF1	0.126	0.132
Rv1432_day32	1.352	1.514
Rv1565c_day32	0.377	0.286
secA2_input	-0.081	-0.291
delta_Rv3594	0.121	-0.427
delta_Rv3717	-0.247	-0.205
delta_Rv3811	-0.223	-0.346
delta_Rv0954	-0.654	-0.275
PonA1	0.069	-0.441
EccD1_KO	-0.664	-0.145
EspI_KO	-0.359	-0.465
PE35_KO	-0.89	-0.23
PPE68_KO	-0.586	-0.221
glycerol2	-0.021	0.907
lignocerate	-0.253	0.6
oleate	-0.223	0.818
phosphatidylcholine	-0.085	0.605
acetate	-0.374	0.038
glucAc	-0.529	0.0
Rv0950ko	0.89	0.317
Rv1096ko	0.983	0.015
Rv3684ko	-0.193	-0.046
delta_otsA_trehalose	3.282	1.375