TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv0456B/mazE1:

update plot	correlation	link to info on gene
Rv0160c/PE4	(cc=0.6442)	info on Rv0160c/PE4
Rv0399c/lpqK	(cc=0.5708)	info on Rv0399c/lpqK
Rv3191c/-	(cc=0.5655)	info on Rv3191c/-
Rv0197/-	(cc=0.5537)	info on Rv0197/-
Rv3397c/phyA	(cc=0.5418)	info on Rv3397c/phyA
Rv0975c/fadE13	(cc=0.5414)	info on Rv0975c/fadE13
Rv0343/iniC	(cc=0.54)	info on Rv0343/iniC
Rv1050/-	(cc=0.5391)	info on Rv1050/-
Rv3329/-	(cc=0.5298)	info on Rv3329/-
Rv0231/fadE4	(cc=0.529)	info on Rv0231/fadE4

Correlation of Rv0456B/mazE1 with Rv1050/-

Normalized LFCs for Rv0456B/mazE1:
(description and provenance of datasets)

	Rv0456B/mazE1	Rv1050/-
Fe_supp_jason_reseq	0.534	-0.873
low_pH_jason_reseq	-0.154	-0.806
NO_jason_reseq	0.126	-1.205
B6_jason_reseq	0.382	-0.97
MHCII_jason_reseq	0.572	-0.189
Isoniazid02	-2.183	-3.091
Rifampicin4	0.471	-1.392
Ethambutol3	-1.78	-3.159
Meropenem3	-1.887	-2.715
Vancomycin16	-0.796	-1.605
Rv2680_day32	0.44	1.019
H37Rv_KO_MarP	-0.282	-0.089
hypoxia_3wks	0.0	-1.109
hypoxia_6wks	-0.186	1.62
glycerol	1.014	0.813
cholesterol	0.351	0.39
AJ	-0.773	-0.65
Bibs02	0.91	0.861
Bibs02c	0.929	-0.226
BL6	0.719	-1.223
BL6a	1.343	0.771
BXD01	0.413	0.727
BXD010	0.671	0.745
BXD011	0.891	1.236
BXD03	-0.017	0.755
BXD04	0.208	1.105
BXD05	1.222	1.459
BXD06	0.799	1.934
BXD07	0.53	1.492
BXD08	0.189	0.42
BXD09	0.657	1.584
CAST	1.068	0.35
CCcont	0.52	0.173
DS01	0.664	-0.099
DS02	0.912	1.134
DS04	0.899	0.642
DS0c	1.276	0.405
GP01	0.382	1.106
GP02	0.811	1.026
GP0c	0.062	0.594
NOD	0.962	-0.57
NZO	0.152	0.474
PWK	-0.213	0.735
H37Rv_KO_CtpC	0.298	0.275
H37Rv_KO_CtpD	0.479	2.006
H37Rv_KO_Rv1272	0.329	0.029
H37Rv_KO_SugABC	0.156	-1.415
H37Rv_KO_MbtN	0.13	0.061
Trans05	0.621	-0.401
macrophage_unactivated	0.59	-2.901
IL1	0.688	0.712
Rapamycin	1.154	-0.964
Tcell	0.218	-0.899
GMCSF	-0.378	-2.03
IFNab	0.438	-0.26
IFNg	0.096	1.045
IFNg_GMCSF1	1.477	-0.412
Rv1432_day32	0.391	0.725
Rv1565c_day32	1.046	-0.201
secA2_input	-0.139	-1.839
delta_Rv3594	-0.473	-0.563
delta_Rv3717	-0.406	-0.405
delta_Rv3811	-0.352	-0.805
delta_Rv0954	-0.279	-1.158
PonA1	0.211	0.633
EccD1_KO	-0.816	-0.414
EspI_KO	-0.57	-0.174
PE35_KO	-0.193	-0.563
PPE68_KO	-0.576	-0.064
glycerol2	0.154	-1.712
lignocerate	0.1	-1.652
oleate	-0.16	-0.8
phosphatidylcholine	0.123	-1.499
acetate	-0.332	-0.713
glucAc	0.019	-1.772
Rv0950ko	0.419	0.838
Rv1096ko	-0.332	0.763
Rv3684ko	0.495	1.385
delta_otsA_trehalose	-0.366	-1.561