TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv0456B/mazE1:

update plot	correlation	link to info on gene
Rv0160c/PE4	(cc=0.6442)	info on Rv0160c/PE4
Rv0399c/lpqK	(cc=0.5708)	info on Rv0399c/lpqK
Rv3191c/-	(cc=0.5655)	info on Rv3191c/-
Rv0197/-	(cc=0.5537)	info on Rv0197/-
Rv3397c/phyA	(cc=0.5418)	info on Rv3397c/phyA
Rv0975c/fadE13	(cc=0.5414)	info on Rv0975c/fadE13
Rv0343/iniC	(cc=0.54)	info on Rv0343/iniC
Rv1050/-	(cc=0.5391)	info on Rv1050/-
Rv3329/-	(cc=0.5298)	info on Rv3329/-
Rv0231/fadE4	(cc=0.529)	info on Rv0231/fadE4

Correlation of Rv0456B/mazE1 with Rv0343/iniC

Normalized LFCs for Rv0456B/mazE1:
(description and provenance of datasets)

	Rv0456B/mazE1	Rv0343/iniC
Fe_supp_jason_reseq	0.534	-0.876
low_pH_jason_reseq	-0.154	0.04
NO_jason_reseq	0.126	1.239
B6_jason_reseq	0.382	-0.246
MHCII_jason_reseq	0.572	0.652
Isoniazid02	-2.183	-1.734
Rifampicin4	0.471	0.609
Ethambutol3	-1.78	-2.748
Meropenem3	-1.887	-2.168
Vancomycin16	-0.796	-0.783
Rv2680_day32	0.44	0.926
H37Rv_KO_MarP	-0.282	1.442
hypoxia_3wks	0.0	-0.431
hypoxia_6wks	-0.186	-0.123
glycerol	1.014	0.635
cholesterol	0.351	0.014
AJ	-0.773	0.064
Bibs02	0.91	0.034
Bibs02c	0.929	-0.508
BL6	0.719	-0.024
BL6a	1.343	0.212
BXD01	0.413	0.128
BXD010	0.671	-0.223
BXD011	0.891	-0.113
BXD03	-0.017	-0.593
BXD04	0.208	0.432
BXD05	1.222	0.013
BXD06	0.799	-0.202
BXD07	0.53	-0.136
BXD08	0.189	0.826
BXD09	0.657	0.984
CAST	1.068	0.38
CCcont	0.52	-0.473
DS01	0.664	-0.282
DS02	0.912	0.158
DS04	0.899	-0.294
DS0c	1.276	0.605
GP01	0.382	0.08
GP02	0.811	-0.242
GP0c	0.062	-0.102
NOD	0.962	0.753
NZO	0.152	0.484
PWK	-0.213	0.446
H37Rv_KO_CtpC	0.298	-0.473
H37Rv_KO_CtpD	0.479	0.93
H37Rv_KO_Rv1272	0.329	0.52
H37Rv_KO_SugABC	0.156	-0.654
H37Rv_KO_MbtN	0.13	-1.606
Trans05	0.621	1.367
macrophage_unactivated	0.59	0.098
IL1	0.688	0.0
Rapamycin	1.154	-0.976
Tcell	0.218	0.101
GMCSF	-0.378	-0.737
IFNab	0.438	0.369
IFNg	0.096	0.97
IFNg_GMCSF1	1.477	1.511
Rv1432_day32	0.391	-0.416
Rv1565c_day32	1.046	0.719
secA2_input	-0.139	-0.216
delta_Rv3594	-0.473	-0.854
delta_Rv3717	-0.406	-1.719
delta_Rv3811	-0.352	0.326
delta_Rv0954	-0.279	-0.085
PonA1	0.211	0.048
EccD1_KO	-0.816	0.194
EspI_KO	-0.57	-0.362
PE35_KO	-0.193	-0.143
PPE68_KO	-0.576	-0.579
glycerol2	0.154	0.104
lignocerate	0.1	0.125
oleate	-0.16	0.384
phosphatidylcholine	0.123	-0.098
acetate	-0.332	-0.158
glucAc	0.019	-0.267
Rv0950ko	0.419	-0.087
Rv1096ko	-0.332	-0.133
Rv3684ko	0.495	0.0
delta_otsA_trehalose	-0.366	-1.182