TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv0447c/ufaA1:
Show top 50 genes. Show bottom 10 genes with LOWEST correlation.

Most correlated genes.

update plot	correlation	link to info on gene
Rv2725c/hflX	(cc=0.6296)	info on Rv2725c/hflX
Rv3655c/-	(cc=0.6047)	info on Rv3655c/-
Rv3062/ligB	(cc=0.6017)	info on Rv3062/ligB
Rv2872/vapC43	(cc=0.5796)	info on Rv2872/vapC43
Rv1046c/-	(cc=0.5766)	info on Rv1046c/-
Rv2484c/-	(cc=0.557)	info on Rv2484c/-
Rv0233/nrdB	(cc=0.5421)	info on Rv0233/nrdB
Rv0103c/ctpB	(cc=0.5414)	info on Rv0103c/ctpB
Rv0569/-	(cc=0.5325)	info on Rv0569/-
Rv2598/-	(cc=0.5292)	info on Rv2598/-

Correlation of Rv0447c/ufaA1 with Rv2725c/hflX

Normalized LFCs for Rv0447c/ufaA1:
(description and provenance of datasets)

Comparison of LFCs between selected condtions.

condition	Rv0447c/ufaA1	Rv2725c/hflX
Fe_supp_jason_reseq	-0.09	-0.161
low_pH_jason_reseq	-0.622	-0.228
NO_jason_reseq	0.0	0.457
B6_jason_reseq	0.083	0.476
MHCII_jason_reseq	0.768	0.458
Isoniazid02	-0.291	1.215
Rifampicin4	-0.089	0.03
Ethambutol3	0.964	0.161
Meropenem3	0.211	1.511
Vancomycin16	0.0	0.045
Rv2680_day32	0.409	0.59
H37Rv_KO_MarP	-0.104	0.055
hypoxia_3wks	-0.179	0.355
hypoxia_6wks	-0.19	-0.073
glycerol	-0.161	0.543
cholesterol	-0.147	0.351
AJ	-0.439	0.193
Bibs02	0.012	0.266
Bibs02c	-0.182	0.244
BL6	-0.623	-1.269
BL6a	-0.455	-0.208
BXD01	-0.86	-0.51
BXD010	-0.354	-0.452
BXD011	-0.523	-0.809
BXD03	-1.102	-1.026
BXD04	0.169	-0.185
BXD05	-0.475	-0.94
BXD06	-0.73	-0.623
BXD07	-0.425	-0.631
BXD08	-0.345	-0.546
BXD09	0.113	-0.875
CAST	0.038	0.355
CCcont	-0.843	-1.043
DS01	0.181	0.406
DS02	0.323	0.323
DS04	0.26	0.254
DS0c	0.014	0.239
GP01	-0.406	-0.677
GP02	-0.157	-0.479
GP0c	-0.842	-0.968
NOD	1.05	2.034
NZO	-0.238	-0.061
PWK	0.09	-0.142
H37Rv_KO_CtpC	-0.499	-0.367
H37Rv_KO_CtpD	-0.128	0.28
H37Rv_KO_Rv1272	-0.36	-0.579
H37Rv_KO_SugABC	-0.22	-0.332
H37Rv_KO_MbtN	-0.855	-1.221
Trans05	-0.191	-0.327
macrophage_unactivated	-0.114	-0.3
IL1	-0.125	-0.478
Rapamycin	0.331	-0.046
Tcell	-0.684	-0.723
GMCSF	-0.243	-0.082
IFNab	-0.109	0.136
IFNg	-0.128	0.198
IFNg_GMCSF1	0.236	0.302
Rv1432_day32	0.94	0.527
Rv1565c_day32	-0.216	0.903
secA2_input	0.243	0.131
delta_Rv3594	-0.369	0.234
delta_Rv3717	-0.332	-0.122
delta_Rv3811	-0.079	0.181
delta_Rv0954	0.025	-0.154
PonA1	0.158	0.538
EccD1_KO	0.533	0.898
EspI_KO	0.659	1.021
PE35_KO	-0.298	0.0
PPE68_KO	0.106	0.022
glycerol2	-0.092	0.242
lignocerate	-0.08	-0.578
oleate	0.319	0.302
phosphatidylcholine	-0.113	-0.025
acetate	-0.012	-0.698
glucAc	-0.436	-0.713
Rv0950ko	0.742	0.16
Rv1096ko	0.992	-0.081
Rv3684ko	0.897	-0.226
delta_otsA_trehalose	0.461	0.692