TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv0411c/glnH:

update plot	correlation	link to info on gene
Rv0410c/pknG	(cc=0.8709)	info on Rv0410c/pknG
Rv0412c/-	(cc=0.8605)	info on Rv0412c/-
Rv1436/gap	(cc=0.7423)	info on Rv1436/gap
Rv2115c/mpa	(cc=0.7246)	info on Rv2115c/mpa
Rv2844/-	(cc=0.7226)	info on Rv2844/-
Rv1002c/-	(cc=0.7193)	info on Rv1002c/-
Rv2130c/mshC	(cc=0.7071)	info on Rv2130c/mshC
Rv0180c/-	(cc=0.7034)	info on Rv0180c/-
Rv2507/-	(cc=0.6838)	info on Rv2507/-
Rv1122/gnd2	(cc=0.6343)	info on Rv1122/gnd2

Correlation of Rv0411c/glnH with Rv0412c/-

Normalized LFCs for Rv0411c/glnH:
(description and provenance of datasets)

	Rv0411c/glnH	Rv0412c/-
Fe_supp_jason_reseq	0.923	0.218
low_pH_jason_reseq	0.0	0.0
NO_jason_reseq	0.0	0.0
B6_jason_reseq	0.0	0.0
MHCII_jason_reseq	0.0	0.0
Isoniazid02	-0.383	-0.201
Rifampicin4	-0.712	-0.374
Ethambutol3	-0.32	-0.168
Meropenem3	-0.315	-0.165
Vancomycin16	-0.698	-0.366
Rv2680_day32	-0.554	-0.459
H37Rv_KO_MarP	-3.512	-3.728
hypoxia_3wks	0.0	0.0
hypoxia_6wks	0.0	0.0
glycerol	0.0	0.0
cholesterol	0.0	0.0
AJ	0.0	0.0
Bibs02	0.0	0.0
Bibs02c	0.0	0.0
BL6	0.0	0.0
BL6a	0.198	0.0
BXD01	0.0	0.0
BXD010	0.0	0.0
BXD011	0.0	0.127
BXD03	0.0	0.0
BXD04	0.0	0.0
BXD05	0.0	0.0
BXD06	0.0	0.0
BXD07	0.0	0.0
BXD08	0.0	0.0
BXD09	0.0	0.0
CAST	0.0	0.0
CCcont	1.43	1.082
DS01	0.0	0.0
DS02	0.0	0.0
DS04	0.0	0.0
DS0c	1.455	0.0
GP01	0.0	0.0
GP02	0.0	0.0
GP0c	0.0	0.0
NOD	0.0	0.0
NZO	0.0	0.0
PWK	0.0	0.0
H37Rv_KO_CtpC	0.688	0.162
H37Rv_KO_CtpD	0.348	0.537
H37Rv_KO_Rv1272	0.0	0.0
H37Rv_KO_SugABC	0.0	0.0
H37Rv_KO_MbtN	0.283	0.506
Trans05	0.0	0.0
macrophage_unactivated	0.0	0.0
IL1	0.0	0.0
Rapamycin	0.0	0.0
Tcell	0.0	0.0
GMCSF	0.0	0.0
IFNab	0.0	0.0
IFNg	0.0	0.0
IFNg_GMCSF1	0.0	0.0
Rv1432_day32	0.0	0.0
Rv1565c_day32	0.0	0.0
secA2_input	-0.477	-0.045
delta_Rv3594	-0.211	-0.211
delta_Rv3717	-0.174	-0.174
delta_Rv3811	-0.205	-0.205
delta_Rv0954	1.292	1.375
PonA1	4.34	4.458
EccD1_KO	1.059	-1.799
EspI_KO	1.146	-0.838
PE35_KO	4.311	2.972
PPE68_KO	4.163	2.476
glycerol2	-0.531	0.0
lignocerate	-0.462	0.0
oleate	-0.537	0.0
phosphatidylcholine	-0.531	0.0
acetate	-0.63	0.0
glucAc	-0.392	0.0
Rv0950ko	-1.523	-1.134
Rv1096ko	0.0	-0.09
Rv3684ko	1.772	1.647
delta_otsA_trehalose	-1.275	-0.564