TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv0276/-:

update plot	correlation	link to info on gene
Rv0303/-	(cc=0.5835)	info on Rv0303/-
Rv0268c/-	(cc=0.5686)	info on Rv0268c/-
Rv0650/-	(cc=0.5295)	info on Rv0650/-
Rv0347/-	(cc=0.5126)	info on Rv0347/-
Rv0447c/ufaA1	(cc=0.5069)	info on Rv0447c/ufaA1
Rv2395/-	(cc=0.4863)	info on Rv2395/-
Rv2771c/-	(cc=0.4781)	info on Rv2771c/-
Rv3070/-	(cc=0.4657)	info on Rv3070/-
Rv0851c/-	(cc=0.4607)	info on Rv0851c/-
Rv3839/-	(cc=0.4571)	info on Rv3839/-

Correlation of Rv0276/- with Rv3070/-

Normalized LFCs for Rv0276/-:
(description and provenance of datasets)

	Rv0276/-	Rv3070/-
Fe_supp_jason_reseq	-0.807	-0.529
low_pH_jason_reseq	-0.855	-0.878
NO_jason_reseq	-0.113	-0.494
B6_jason_reseq	0.322	-1.15
MHCII_jason_reseq	0.118	-0.669
Isoniazid02	0.141	-0.035
Rifampicin4	-0.23	-0.996
Ethambutol3	0.238	-0.524
Meropenem3	-0.272	-0.422
Vancomycin16	0.478	-0.369
Rv2680_day32	0.73	0.899
H37Rv_KO_MarP	0.452	0.233
hypoxia_3wks	-0.12	-0.088
hypoxia_6wks	-0.194	0.28
glycerol	-0.297	-0.788
cholesterol	0.193	-0.981
AJ	0.277	1.077
Bibs02	0.335	0.838
Bibs02c	0.108	1.085
BL6	0.3	0.327
BL6a	0.112	1.378
BXD01	-0.035	0.993
BXD010	-0.135	0.792
BXD011	0.347	0.285
BXD03	-0.241	1.018
BXD04	0.613	0.43
BXD05	0.451	0.237
BXD06	-0.164	1.196
BXD07	0.421	0.75
BXD08	-0.287	0.944
BXD09	0.142	0.991
CAST	0.619	0.586
CCcont	-0.211	1.06
DS01	0.525	-0.068
DS02	0.714	0.469
DS04	0.177	1.018
DS0c	0.187	0.273
GP01	0.094	-0.706
GP02	-1.435	-1.474
GP0c	-0.51	-0.117
NOD	1.435	1.015
NZO	-0.075	-0.724
PWK	0.746	0.735
H37Rv_KO_CtpC	0.067	0.934
H37Rv_KO_CtpD	-0.282	0.44
H37Rv_KO_Rv1272	0.195	0.637
H37Rv_KO_SugABC	-0.128	-1.705
H37Rv_KO_MbtN	-0.898	-1.164
Trans05	0.061	0.445
macrophage_unactivated	0.139	0.726
IL1	0.706	0.771
Rapamycin	-0.258	0.393
Tcell	-0.098	0.626
GMCSF	-0.201	0.317
IFNab	0.112	0.212
IFNg	0.174	0.831
IFNg_GMCSF1	0.789	1.241
Rv1432_day32	-0.1	-0.257
Rv1565c_day32	-0.046	0.12
secA2_input	0.928	-0.177
delta_Rv3594	-0.441	1.054
delta_Rv3717	-0.622	-1.258
delta_Rv3811	-0.669	0.043
delta_Rv0954	0.557	0.89
PonA1	-0.44	0.177
EccD1_KO	-0.26	-0.082
EspI_KO	-0.385	-0.736
PE35_KO	-0.738	1.138
PPE68_KO	-0.618	0.08
glycerol2	0.135	0.342
lignocerate	0.418	0.485
oleate	0.262	0.116
phosphatidylcholine	0.28	0.312
acetate	-0.083	0.146
glucAc	0.051	0.102
Rv0950ko	1.604	0.709
Rv1096ko	1.514	1.173
Rv3684ko	1.837	2.227
delta_otsA_trehalose	1.079	0.049