TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv0276/-:

update plot	correlation	link to info on gene
Rv0303/-	(cc=0.5835)	info on Rv0303/-
Rv0268c/-	(cc=0.5686)	info on Rv0268c/-
Rv0650/-	(cc=0.5295)	info on Rv0650/-
Rv0347/-	(cc=0.5126)	info on Rv0347/-
Rv0447c/ufaA1	(cc=0.5069)	info on Rv0447c/ufaA1
Rv2395/-	(cc=0.4863)	info on Rv2395/-
Rv2771c/-	(cc=0.4781)	info on Rv2771c/-
Rv3070/-	(cc=0.4657)	info on Rv3070/-
Rv0851c/-	(cc=0.4607)	info on Rv0851c/-
Rv3839/-	(cc=0.4571)	info on Rv3839/-

Correlation of Rv0276/- with Rv2771c/-

Normalized LFCs for Rv0276/-:
(description and provenance of datasets)

	Rv0276/-	Rv2771c/-
Fe_supp_jason_reseq	-0.807	0.126
low_pH_jason_reseq	-0.855	-0.489
NO_jason_reseq	-0.113	0.024
B6_jason_reseq	0.322	0.657
MHCII_jason_reseq	0.118	0.783
Isoniazid02	0.141	-0.167
Rifampicin4	-0.23	0.097
Ethambutol3	0.238	1.477
Meropenem3	-0.272	0.157
Vancomycin16	0.478	-0.231
Rv2680_day32	0.73	0.025
H37Rv_KO_MarP	0.452	-0.041
hypoxia_3wks	-0.12	0.455
hypoxia_6wks	-0.194	0.357
glycerol	-0.297	-0.84
cholesterol	0.193	-0.217
AJ	0.277	0.603
Bibs02	0.335	0.46
Bibs02c	0.108	0.571
BL6	0.3	-0.014
BL6a	0.112	0.383
BXD01	-0.035	-0.765
BXD010	-0.135	-0.636
BXD011	0.347	0.137
BXD03	-0.241	-0.167
BXD04	0.613	0.169
BXD05	0.451	0.294
BXD06	-0.164	-0.171
BXD07	0.421	-0.208
BXD08	-0.287	-0.228
BXD09	0.142	-0.249
CAST	0.619	0.654
CCcont	-0.211	-0.433
DS01	0.525	0.289
DS02	0.714	0.614
DS04	0.177	-0.104
DS0c	0.187	0.124
GP01	0.094	0.011
GP02	-1.435	0.072
GP0c	-0.51	-0.009
NOD	1.435	0.391
NZO	-0.075	-0.433
PWK	0.746	-0.014
H37Rv_KO_CtpC	0.067	0.475
H37Rv_KO_CtpD	-0.282	0.384
H37Rv_KO_Rv1272	0.195	-0.037
H37Rv_KO_SugABC	-0.128	0.126
H37Rv_KO_MbtN	-0.898	-0.653
Trans05	0.061	-0.503
macrophage_unactivated	0.139	-0.745
IL1	0.706	-0.626
Rapamycin	-0.258	-0.494
Tcell	-0.098	-0.593
GMCSF	-0.201	-0.578
IFNab	0.112	-0.248
IFNg	0.174	0.254
IFNg_GMCSF1	0.789	0.478
Rv1432_day32	-0.1	0.939
Rv1565c_day32	-0.046	0.041
secA2_input	0.928	0.421
delta_Rv3594	-0.441	-0.482
delta_Rv3717	-0.622	-0.785
delta_Rv3811	-0.669	-0.174
delta_Rv0954	0.557	-0.478
PonA1	-0.44	-0.398
EccD1_KO	-0.26	-0.329
EspI_KO	-0.385	-0.22
PE35_KO	-0.738	-0.21
PPE68_KO	-0.618	-0.729
glycerol2	0.135	0.006
lignocerate	0.418	0.052
oleate	0.262	-0.33
phosphatidylcholine	0.28	0.165
acetate	-0.083	-0.449
glucAc	0.051	-0.094
Rv0950ko	1.604	0.621
Rv1096ko	1.514	0.175
Rv3684ko	1.837	1.182
delta_otsA_trehalose	1.079	1.116