TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv0273c/-:

update plot	correlation	link to info on gene
Rv1550/fadD11	(cc=0.5223)	info on Rv1550/fadD11
Rv1191/-	(cc=0.5107)	info on Rv1191/-
Rv3539/PPE63	(cc=0.4803)	info on Rv3539/PPE63
Rv2451/-	(cc=0.4653)	info on Rv2451/-
Rv2643/arsC	(cc=0.437)	info on Rv2643/arsC
Rv2769c/PE27	(cc=0.4351)	info on Rv2769c/PE27
Rv3761c/fadE36	(cc=0.4131)	info on Rv3761c/fadE36
Rv0687/-	(cc=0.4093)	info on Rv0687/-
Rv2311/-	(cc=0.4084)	info on Rv2311/-
Rv2405/-	(cc=0.4041)	info on Rv2405/-

Correlation of Rv0273c/- with Rv2311/-

Normalized LFCs for Rv0273c/-:
(description and provenance of datasets)

	Rv0273c/-	Rv2311/-
Fe_supp_jason_reseq	-0.497	0.777
low_pH_jason_reseq	-0.465	-0.786
NO_jason_reseq	-0.16	-0.336
B6_jason_reseq	-0.25	0.515
MHCII_jason_reseq	0.358	0.316
Isoniazid02	0.24	0.406
Rifampicin4	0.0	-0.699
Ethambutol3	0.338	0.353
Meropenem3	3.393	2.554
Vancomycin16	0.738	-0.366
Rv2680_day32	-0.305	-0.392
H37Rv_KO_MarP	0.941	0.457
hypoxia_3wks	0.203	-0.945
hypoxia_6wks	0.0	-0.142
glycerol	0.0	0.006
cholesterol	-0.396	-0.729
AJ	-0.17	-0.074
Bibs02	-0.827	0.086
Bibs02c	-0.459	0.035
BL6	0.42	0.604
BL6a	-0.237	0.6
BXD01	0.896	0.416
BXD010	-1.253	0.313
BXD011	0.427	0.611
BXD03	-0.099	0.262
BXD04	0.427	0.007
BXD05	0.195	0.358
BXD06	0.786	0.515
BXD07	0.361	0.533
BXD08	-0.039	0.225
BXD09	0.204	0.896
CAST	0.063	0.164
CCcont	0.102	0.306
DS01	-0.32	0.731
DS02	-0.983	0.222
DS04	0.305	1.716
DS0c	-0.328	0.143
GP01	0.858	-0.235
GP02	-0.452	-1.277
GP0c	0.311	0.211
NOD	-0.13	0.063
NZO	0.669	0.428
PWK	-0.028	-0.138
H37Rv_KO_CtpC	0.545	-0.119
H37Rv_KO_CtpD	-0.112	0.517
H37Rv_KO_Rv1272	0.796	0.226
H37Rv_KO_SugABC	0.447	-0.312
H37Rv_KO_MbtN	-0.636	1.391
Trans05	0.648	0.553
macrophage_unactivated	0.0	0.77
IL1	-0.581	0.356
Rapamycin	0.236	-0.307
Tcell	0.411	-0.029
GMCSF	-1.31	0.024
IFNab	-0.877	0.862
IFNg	-0.446	-0.136
IFNg_GMCSF1	0.082	0.6
Rv1432_day32	0.155	0.338
Rv1565c_day32	0.306	-0.325
secA2_input	1.335	0.465
delta_Rv3594	0.067	0.999
delta_Rv3717	0.307	0.628
delta_Rv3811	0.745	0.477
delta_Rv0954	-0.028	0.832
PonA1	0.366	-0.47
EccD1_KO	-0.977	0.22
EspI_KO	-0.228	-0.123
PE35_KO	-0.201	0.265
PPE68_KO	-0.413	0.096
glycerol2	0.752	0.467
lignocerate	0.444	0.916
oleate	0.669	-0.388
phosphatidylcholine	0.776	0.857
acetate	0.106	0.545
glucAc	-0.363	0.746
Rv0950ko	0.443	0.504
Rv1096ko	0.115	-0.13
Rv3684ko	-0.085	0.809
delta_otsA_trehalose	-2.517	-1.41