TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv0273c/-:

update plot	correlation	link to info on gene
Rv1550/fadD11	(cc=0.5223)	info on Rv1550/fadD11
Rv1191/-	(cc=0.5107)	info on Rv1191/-
Rv3539/PPE63	(cc=0.4803)	info on Rv3539/PPE63
Rv2451/-	(cc=0.4653)	info on Rv2451/-
Rv2643/arsC	(cc=0.437)	info on Rv2643/arsC
Rv2769c/PE27	(cc=0.4351)	info on Rv2769c/PE27
Rv3761c/fadE36	(cc=0.4131)	info on Rv3761c/fadE36
Rv0687/-	(cc=0.4093)	info on Rv0687/-
Rv2311/-	(cc=0.4084)	info on Rv2311/-
Rv2405/-	(cc=0.4041)	info on Rv2405/-

Correlation of Rv0273c/- with Rv0687/-

Normalized LFCs for Rv0273c/-:
(description and provenance of datasets)

	Rv0273c/-	Rv0687/-
Fe_supp_jason_reseq	-0.497	-1.187
low_pH_jason_reseq	-0.465	0.805
NO_jason_reseq	-0.16	0.412
B6_jason_reseq	-0.25	-0.312
MHCII_jason_reseq	0.358	-0.311
Isoniazid02	0.24	1.116
Rifampicin4	0.0	1.083
Ethambutol3	0.338	1.198
Meropenem3	3.393	3.163
Vancomycin16	0.738	1.061
Rv2680_day32	-0.305	-0.637
H37Rv_KO_MarP	0.941	-0.189
hypoxia_3wks	0.203	-0.311
hypoxia_6wks	0.0	0.867
glycerol	0.0	-0.764
cholesterol	-0.396	-0.391
AJ	-0.17	0.316
Bibs02	-0.827	-0.624
Bibs02c	-0.459	-1.381
BL6	0.42	-0.89
BL6a	-0.237	-1.075
BXD01	0.896	-0.518
BXD010	-1.253	-1.907
BXD011	0.427	-1.009
BXD03	-0.099	-1.15
BXD04	0.427	-1.209
BXD05	0.195	-1.271
BXD06	0.786	-1.261
BXD07	0.361	-0.847
BXD08	-0.039	-0.091
BXD09	0.204	-1.374
CAST	0.063	0.177
CCcont	0.102	-0.403
DS01	-0.32	-0.298
DS02	-0.983	-0.443
DS04	0.305	0.538
DS0c	-0.328	0.167
GP01	0.858	0.0
GP02	-0.452	-1.195
GP0c	0.311	0.677
NOD	-0.13	-1.219
NZO	0.669	0.201
PWK	-0.028	-0.026
H37Rv_KO_CtpC	0.545	0.164
H37Rv_KO_CtpD	-0.112	0.942
H37Rv_KO_Rv1272	0.796	-0.221
H37Rv_KO_SugABC	0.447	-0.583
H37Rv_KO_MbtN	-0.636	0.164
Trans05	0.648	0.513
macrophage_unactivated	0.0	-1.61
IL1	-0.581	-1.385
Rapamycin	0.236	-1.841
Tcell	0.411	-1.522
GMCSF	-1.31	-0.082
IFNab	-0.877	-1.542
IFNg	-0.446	-1.136
IFNg_GMCSF1	0.082	0.371
Rv1432_day32	0.155	-0.661
Rv1565c_day32	0.306	1.469
secA2_input	1.335	0.967
delta_Rv3594	0.067	1.744
delta_Rv3717	0.307	1.085
delta_Rv3811	0.745	1.558
delta_Rv0954	-0.028	0.238
PonA1	0.366	0.974
EccD1_KO	-0.977	-0.187
EspI_KO	-0.228	-0.625
PE35_KO	-0.201	-0.455
PPE68_KO	-0.413	-0.499
glycerol2	0.752	0.635
lignocerate	0.444	0.061
oleate	0.669	0.912
phosphatidylcholine	0.776	0.326
acetate	0.106	-0.266
glucAc	-0.363	0.026
Rv0950ko	0.443	-0.241
Rv1096ko	0.115	-0.564
Rv3684ko	-0.085	-1.15
delta_otsA_trehalose	-2.517	0.333