TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv0060/-:

update plot	correlation	link to info on gene
Rv2219/-	(cc=0.5267)	info on Rv2219/-
Rv0945/-	(cc=0.526)	info on Rv0945/-
Rv3819/-	(cc=0.5134)	info on Rv3819/-
Rv2237/-	(cc=0.5052)	info on Rv2237/-
Rv3224B/-	(cc=0.5046)	info on Rv3224B/-
Rv3224A/-	(cc=0.5002)	info on Rv3224A/-
Rv0312/-	(cc=0.4982)	info on Rv0312/-
Rv1987/-	(cc=0.4959)	info on Rv1987/-
Rv0887c/-	(cc=0.486)	info on Rv0887c/-
Rv3217c/-	(cc=0.4839)	info on Rv3217c/-

Correlation of Rv0060/- with Rv3224B/-

Normalized LFCs for Rv0060/-:
(description and provenance of datasets)

	Rv0060/-	Rv3224B/-
Fe_supp_jason_reseq	0.391	1.613
low_pH_jason_reseq	-1.134	0.582
NO_jason_reseq	0.0	1.003
B6_jason_reseq	0.0	1.336
MHCII_jason_reseq	0.085	-0.043
Isoniazid02	0.263	0.0
Rifampicin4	0.712	0.43
Ethambutol3	0.505	-0.204
Meropenem3	0.662	2.432
Vancomycin16	0.48	-0.202
Rv2680_day32	-0.554	1.574
H37Rv_KO_MarP	0.35	-0.34
hypoxia_3wks	-0.606	-1.798
hypoxia_6wks	0.146	-0.764
glycerol	0.222	-1.318
cholesterol	0.0	-0.644
AJ	0.131	0.338
Bibs02	-1.123	1.041
Bibs02c	0.629	0.32
BL6	0.53	2.331
BL6a	0.595	0.016
BXD01	0.905	0.306
BXD010	-0.543	-0.741
BXD011	0.268	-0.167
BXD03	0.52	0.361
BXD04	-0.325	0.999
BXD05	0.216	-0.022
BXD06	0.342	-0.239
BXD07	0.0	0.12
BXD08	0.0	0.422
BXD09	-0.173	-0.917
CAST	0.976	0.384
CCcont	1.498	0.0
DS01	-0.45	-0.905
DS02	1.235	0.156
DS04	0.312	-1.487
DS0c	-0.737	-1.483
GP01	0.056	0.393
GP02	-0.283	-1.146
GP0c	0.942	0.18
NOD	0.0	-0.037
NZO	0.6	0.829
PWK	0.905	-0.134
H37Rv_KO_CtpC	0.977	-1.011
H37Rv_KO_CtpD	0.989	2.225
H37Rv_KO_Rv1272	0.227	-1.207
H37Rv_KO_SugABC	0.877	-0.776
H37Rv_KO_MbtN	-0.633	0.961
Trans05	-0.554	0.957
macrophage_unactivated	1.531	1.285
IL1	-0.297	-1.99
Rapamycin	0.0	-0.546
Tcell	1.352	1.942
GMCSF	-0.264	-0.784
IFNab	0.0	-0.426
IFNg	-0.551	0.583
IFNg_GMCSF1	-0.314	-1.2
Rv1432_day32	0.0	0.321
Rv1565c_day32	-0.218	-1.093
secA2_input	0.812	0.167
delta_Rv3594	0.961	0.382
delta_Rv3717	1.851	-1.565
delta_Rv3811	1.335	1.008
delta_Rv0954	0.0	0.27
PonA1	-0.245	-0.851
EccD1_KO	0.582	-1.092
EspI_KO	-0.787	-2.738
PE35_KO	-0.589	-2.033
PPE68_KO	-1.133	-0.749
glycerol2	1.964	2.191
lignocerate	2.404	2.565
oleate	-0.688	-1.167
phosphatidylcholine	1.909	2.333
acetate	2.128	3.501
glucAc	1.868	2.476
Rv0950ko	0.639	0.112
Rv1096ko	1.194	0.531
Rv3684ko	0.0	0.062
delta_otsA_trehalose	0.366	-0.835