TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv3917c/parB:

update plot	correlation	link to info on gene
Rv3694c/-	(cc=0.4906)	info on Rv3694c/-
Rv1500/-	(cc=0.4799)	info on Rv1500/-
Rv2443/dctA	(cc=0.474)	info on Rv2443/dctA
Rv0309/-	(cc=0.47)	info on Rv0309/-
Rv2584c/apt	(cc=0.4457)	info on Rv2584c/apt
Rv2430c/PPE41	(cc=0.4374)	info on Rv2430c/PPE41
Rv1509/-	(cc=0.4321)	info on Rv1509/-
Rv2819c/-	(cc=0.4294)	info on Rv2819c/-
Rv2586c/secF	(cc=0.4251)	info on Rv2586c/secF
Rv2274c/mazF8	(cc=0.4212)	info on Rv2274c/mazF8

Correlation of Rv3917c/parB with Rv2586c/secF

Normalized LFCs for Rv3917c/parB:
(description and provenance of datasets)

	Rv3917c/parB	Rv2586c/secF
Fe_supp_jason_reseq	-0.655	0.0
low_pH_jason_reseq	-0.905	-2.695
NO_jason_reseq	-1.42	-0.213
B6_jason_reseq	0.189	-0.77
MHCII_jason_reseq	-0.663	-1.357
Isoniazid02	-0.281	0.061
Rifampicin4	-0.523	0.826
Ethambutol3	-0.365	-1.116
Meropenem3	-0.359	-0.274
Vancomycin16	0.0	0.218
Rv2680_day32	0.0	-1.357
H37Rv_KO_MarP	-0.825	-1.542
hypoxia_3wks	-0.55	0.486
hypoxia_6wks	0.263	0.637
glycerol	0.0	-1.198
cholesterol	0.0	0.0
AJ	1.14	0.815
Bibs02	0.0	0.733
Bibs02c	0.0	0.141
BL6	0.238	1.181
BL6a	0.377	0.489
BXD01	0.0	0.044
BXD010	0.0	0.629
BXD011	1.742	2.032
BXD03	0.0	1.537
BXD04	0.124	0.959
BXD05	0.0	1.651
BXD06	0.0	0.82
BXD07	0.0	0.68
BXD08	0.253	0.253
BXD09	0.268	1.018
CAST	0.23	0.866
CCcont	0.285	0.24
DS01	0.0	-0.084
DS02	0.0	0.217
DS04	0.0	0.37
DS0c	0.0	-0.239
GP01	0.0	0.217
GP02	0.0	0.292
GP0c	0.0	0.044
NOD	0.225	0.734
NZO	0.199	0.262
PWK	1.421	2.588
H37Rv_KO_CtpC	0.998	0.998
H37Rv_KO_CtpD	0.0	-0.676
H37Rv_KO_Rv1272	0.0	0.893
H37Rv_KO_SugABC	0.0	0.067
H37Rv_KO_MbtN	0.0	1.275
Trans05	0.0	0.359
macrophage_unactivated	0.761	-0.877
IL1	0.374	-0.219
Rapamycin	0.387	-1.274
Tcell	0.0	1.323
GMCSF	0.0	0.185
IFNab	0.0	0.314
IFNg	0.0	2.475
IFNg_GMCSF1	0.0	2.338
Rv1432_day32	0.0	0.0
Rv1565c_day32	0.0	0.0
secA2_input	-0.759	-2.531
delta_Rv3594	0.0	1.722
delta_Rv3717	-0.563	1.231
delta_Rv3811	0.138	1.282
delta_Rv0954	0.0	-0.756
PonA1	-0.516	-0.463
EccD1_KO	-0.329	0.865
EspI_KO	-0.918	-0.14
PE35_KO	-0.601	0.271
PPE68_KO	0.0	-0.157
glycerol2	0.0	-1.76
lignocerate	0.0	-1.529
oleate	0.0	-0.147
phosphatidylcholine	0.0	-0.94
acetate	0.229	-0.785
glucAc	0.143	-1.218
Rv0950ko	-0.905	-0.528
Rv1096ko	-0.28	-1.128
Rv3684ko	-1.359	-0.888
delta_otsA_trehalose	0.0	0.274