TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv3776/-:

update plot	correlation	link to info on gene
Rv2414c/-	(cc=0.4834)	info on Rv2414c/-
Rv3665c/dppB	(cc=0.4675)	info on Rv3665c/dppB
Rv1177/fdxC	(cc=0.4484)	info on Rv1177/fdxC
Rv2693c/-	(cc=0.4458)	info on Rv2693c/-
Rv2149c/yfiH	(cc=0.4366)	info on Rv2149c/yfiH
Rv2265/-	(cc=0.4215)	info on Rv2265/-
Rv0836c/-	(cc=0.4204)	info on Rv0836c/-
Rv3440c/-	(cc=0.414)	info on Rv3440c/-
Rv1944c/-	(cc=0.4056)	info on Rv1944c/-
Rv0209/-	(cc=0.4034)	info on Rv0209/-

Correlation of Rv3776/- with Rv2693c/-

Normalized LFCs for Rv3776/-:
(description and provenance of datasets)

	Rv3776/-	Rv2693c/-
Fe_supp_jason_reseq	-0.406	0.349
low_pH_jason_reseq	1.193	1.193
NO_jason_reseq	0.034	0.113
B6_jason_reseq	-0.219	-0.112
MHCII_jason_reseq	-0.207	0.999
Isoniazid02	0.655	0.249
Rifampicin4	-0.255	-0.899
Ethambutol3	1.284	1.888
Meropenem3	-0.35	-1.457
Vancomycin16	-0.186	-0.573
Rv2680_day32	0.307	0.363
H37Rv_KO_MarP	0.316	-0.068
hypoxia_3wks	-0.271	-1.982
hypoxia_6wks	-0.468	-0.768
glycerol	0.12	0.699
cholesterol	-0.169	-0.177
AJ	0.282	0.059
Bibs02	0.642	0.476
Bibs02c	0.67	-0.111
BL6	0.355	0.45
BL6a	0.263	-0.052
BXD01	0.235	-0.652
BXD010	-0.444	-0.526
BXD011	-0.327	-0.806
BXD03	-0.009	-1.174
BXD04	0.503	-0.711
BXD05	-0.042	0.108
BXD06	-0.213	-0.6
BXD07	-0.182	-0.18
BXD08	0.198	0.009
BXD09	-0.339	-0.703
CAST	0.404	-0.315
CCcont	0.173	-0.068
DS01	0.438	0.672
DS02	0.912	0.069
DS04	0.485	0.278
DS0c	0.625	0.531
GP01	0.849	-0.242
GP02	1.226	0.837
GP0c	0.624	1.054
NOD	0.867	-0.443
NZO	0.221	-0.091
PWK	0.139	-0.806
H37Rv_KO_CtpC	0.351	0.562
H37Rv_KO_CtpD	0.406	0.336
H37Rv_KO_Rv1272	-0.244	-0.54
H37Rv_KO_SugABC	0.436	-0.724
H37Rv_KO_MbtN	1.29	1.07
Trans05	0.187	0.3
macrophage_unactivated	-0.139	0.597
IL1	0.273	0.089
Rapamycin	0.331	-0.562
Tcell	0.14	-0.45
GMCSF	0.024	-0.364
IFNab	0.051	-0.348
IFNg	-0.069	-0.337
IFNg_GMCSF1	0.239	-1.313
Rv1432_day32	0.716	-0.446
Rv1565c_day32	0.46	1.674
secA2_input	0.668	-0.402
delta_Rv3594	-0.541	0.711
delta_Rv3717	-0.22	0.356
delta_Rv3811	-0.541	0.394
delta_Rv0954	-0.052	-0.071
PonA1	-0.172	0.367
EccD1_KO	-0.247	-0.842
EspI_KO	-0.764	-0.394
PE35_KO	-0.26	-1.205
PPE68_KO	-0.397	-1.645
glycerol2	0.182	0.61
lignocerate	0.274	1.46
oleate	0.133	-0.563
phosphatidylcholine	0.22	1.162
acetate	0.126	-0.045
glucAc	0.059	0.711
Rv0950ko	0.419	0.549
Rv1096ko	0.127	0.329
Rv3684ko	0.219	0.0
delta_otsA_trehalose	-1.085	-0.468