TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv3730c/-:

update plot	correlation	link to info on gene
Rv0669c/-	(cc=0.5623)	info on Rv0669c/-
Rv2173/idsA2	(cc=0.5228)	info on Rv2173/idsA2
Rv2715/-	(cc=0.4507)	info on Rv2715/-
Rv0860/fadB	(cc=0.4428)	info on Rv0860/fadB
Rv1394c/cyp132	(cc=0.4326)	info on Rv1394c/cyp132
Rv1490/-	(cc=0.4236)	info on Rv1490/-
Rv1831/-	(cc=0.4168)	info on Rv1831/-
Rv2307B/-	(cc=0.4081)	info on Rv2307B/-
Rv1722/-	(cc=0.4075)	info on Rv1722/-
Rv1147/-	(cc=0.4053)	info on Rv1147/-

Correlation of Rv3730c/- with Rv0669c/-

Normalized LFCs for Rv3730c/-:
(description and provenance of datasets)

	Rv3730c/-	Rv0669c/-
Fe_supp_jason_reseq	-0.541	-0.156
low_pH_jason_reseq	0.095	-0.582
NO_jason_reseq	0.436	0.039
B6_jason_reseq	-0.565	0.331
MHCII_jason_reseq	-0.352	0.163
Isoniazid02	0.413	0.247
Rifampicin4	0.154	0.0
Ethambutol3	1.653	1.07
Meropenem3	0.229	0.492
Vancomycin16	-0.159	-0.019
Rv2680_day32	0.113	0.483
H37Rv_KO_MarP	0.165	0.344
hypoxia_3wks	0.259	-0.231
hypoxia_6wks	0.685	0.092
glycerol	0.012	0.445
cholesterol	1.229	3.252
AJ	-0.499	0.279
Bibs02	-0.367	0.317
Bibs02c	0.432	-0.03
BL6	0.419	-0.03
BL6a	0.077	-0.135
BXD01	-0.217	0.134
BXD010	-0.075	-0.056
BXD011	0.852	0.12
BXD03	0.046	0.318
BXD04	0.048	0.164
BXD05	0.226	0.121
BXD06	0.096	0.155
BXD07	0.099	0.013
BXD08	0.23	0.209
BXD09	0.023	-0.161
CAST	-0.324	0.237
CCcont	0.0	-0.276
DS01	0.305	0.212
DS02	-0.038	0.386
DS04	0.472	0.513
DS0c	0.459	0.138
GP01	0.18	0.31
GP02	-0.345	-0.395
GP0c	0.127	-0.135
NOD	0.705	0.251
NZO	-0.166	0.247
PWK	0.243	0.269
H37Rv_KO_CtpC	-0.304	-0.127
H37Rv_KO_CtpD	-0.059	0.199
H37Rv_KO_Rv1272	0.217	0.534
H37Rv_KO_SugABC	1.085	1.096
H37Rv_KO_MbtN	0.149	-0.03
Trans05	0.08	-0.076
macrophage_unactivated	0.025	-0.174
IL1	-0.234	-0.486
Rapamycin	-0.071	-0.718
Tcell	-0.179	0.042
GMCSF	-0.124	-0.09
IFNab	-0.466	-0.405
IFNg	-0.388	-0.521
IFNg_GMCSF1	-0.223	-0.493
Rv1432_day32	0.583	0.183
Rv1565c_day32	0.382	-0.22
secA2_input	0.03	-1.021
delta_Rv3594	-0.104	-0.32
delta_Rv3717	-0.031	-0.322
delta_Rv3811	0.309	-0.103
delta_Rv0954	-0.353	-0.91
PonA1	0.383	-0.372
EccD1_KO	0.02	0.385
EspI_KO	0.265	0.642
PE35_KO	0.111	0.076
PPE68_KO	0.259	0.163
glycerol2	0.156	0.815
lignocerate	0.387	0.919
oleate	-0.597	0.333
phosphatidylcholine	-0.09	0.944
acetate	-0.168	0.532
glucAc	0.262	0.573
Rv0950ko	0.163	0.265
Rv1096ko	-0.449	0.066
Rv3684ko	0.151	0.265
delta_otsA_trehalose	-1.599	-1.542