TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv3406/-:

update plot	correlation	link to info on gene
Rv2679/echA15	(cc=0.5782)	info on Rv2679/echA15
Rv0342/iniA	(cc=0.5703)	info on Rv0342/iniA
Rv3504/fadE26	(cc=0.5238)	info on Rv3504/fadE26
Rv3329/-	(cc=0.5224)	info on Rv3329/-
Rv0443/-	(cc=0.5187)	info on Rv0443/-
Rv3397c/phyA	(cc=0.5177)	info on Rv3397c/phyA
Rv3191c/-	(cc=0.505)	info on Rv3191c/-
Rv0399c/lpqK	(cc=0.5021)	info on Rv0399c/lpqK
Rv0968/-	(cc=0.4967)	info on Rv0968/-
Rv0104/-	(cc=0.4936)	info on Rv0104/-

Correlation of Rv3406/- with Rv3504/fadE26

Normalized LFCs for Rv3406/-:
(description and provenance of datasets)

	Rv3406/-	Rv3504/fadE26
Fe_supp_jason_reseq	-0.343	0.145
low_pH_jason_reseq	-0.477	-0.206
NO_jason_reseq	-0.347	-0.147
B6_jason_reseq	-0.298	-0.523
MHCII_jason_reseq	0.298	0.624
Isoniazid02	-1.986	-0.911
Rifampicin4	0.368	0.024
Ethambutol3	-1.893	-1.263
Meropenem3	-0.167	-0.418
Vancomycin16	-0.748	-0.645
Rv2680_day32	-0.062	0.39
H37Rv_KO_MarP	0.524	0.411
hypoxia_3wks	-0.032	0.064
hypoxia_6wks	-0.386	0.144
glycerol	0.023	0.367
cholesterol	-0.246	-0.235
AJ	0.531	0.533
Bibs02	0.201	0.364
Bibs02c	-0.662	0.203
BL6	1.034	-0.25
BL6a	0.145	0.306
BXD01	-0.008	0.014
BXD010	0.811	0.255
BXD011	0.153	0.676
BXD03	-0.158	-0.307
BXD04	0.425	0.387
BXD05	0.565	0.577
BXD06	0.274	-0.199
BXD07	0.336	0.318
BXD08	0.023	-0.103
BXD09	0.494	0.197
CAST	0.46	0.988
CCcont	0.043	-0.074
DS01	0.31	0.691
DS02	-0.05	0.619
DS04	0.077	0.607
DS0c	-0.239	0.754
GP01	0.288	0.586
GP02	1.221	0.9
GP0c	-0.528	-0.079
NOD	0.809	0.478
NZO	-0.194	0.175
PWK	0.512	-0.085
H37Rv_KO_CtpC	-0.067	0.331
H37Rv_KO_CtpD	0.795	-0.213
H37Rv_KO_Rv1272	-0.911	0.204
H37Rv_KO_SugABC	0.155	-0.154
H37Rv_KO_MbtN	-0.211	0.14
Trans05	-0.565	0.238
macrophage_unactivated	-0.331	-0.669
IL1	0.039	-0.739
Rapamycin	-0.04	0.034
Tcell	0.124	0.238
GMCSF	0.195	0.219
IFNab	-0.218	-0.735
IFNg	0.449	-0.786
IFNg_GMCSF1	0.251	0.148
Rv1432_day32	0.252	-0.184
Rv1565c_day32	-0.24	-0.156
secA2_input	-0.016	0.142
delta_Rv3594	-0.465	-0.523
delta_Rv3717	-0.262	-0.069
delta_Rv3811	-0.149	-0.28
delta_Rv0954	0.419	-0.098
PonA1	0.259	-0.208
EccD1_KO	0.691	0.549
EspI_KO	0.046	0.539
PE35_KO	-0.047	-0.076
PPE68_KO	-0.211	0.275
glycerol2	0.553	-0.471
lignocerate	0.225	-0.24
oleate	0.527	0.51
phosphatidylcholine	0.5	-0.057
acetate	0.219	-0.502
glucAc	0.06	-0.849
Rv0950ko	0.573	0.395
Rv1096ko	0.694	1.059
Rv3684ko	0.151	0.652
delta_otsA_trehalose	1.329	1.387