TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv3351c/-:

update plot	correlation	link to info on gene
Rv0072/-	(cc=0.4804)	info on Rv0072/-
Rv0305c/PPE6	(cc=0.4753)	info on Rv0305c/PPE6
Rv2665/-	(cc=0.4546)	info on Rv2665/-
Rv1948c/-	(cc=0.4485)	info on Rv1948c/-
Rv3440c/-	(cc=0.4421)	info on Rv3440c/-
Rv1145/mmpL13a	(cc=0.4416)	info on Rv1145/mmpL13a
Rv0832/PE_PGRS12	(cc=0.4345)	info on Rv0832/PE_PGRS12
Rv0194/-	(cc=0.4315)	info on Rv0194/-
Rv0138/-	(cc=0.431)	info on Rv0138/-
Rv2436/rbsK	(cc=0.4277)	info on Rv2436/rbsK

Correlation of Rv3351c/- with Rv0138/-

Normalized LFCs for Rv3351c/-:
(description and provenance of datasets)

	Rv3351c/-	Rv0138/-
Fe_supp_jason_reseq	-0.014	-0.759
low_pH_jason_reseq	-0.36	-0.778
NO_jason_reseq	-0.108	-0.131
B6_jason_reseq	-0.684	-0.133
MHCII_jason_reseq	0.108	-0.222
Isoniazid02	-0.282	1.099
Rifampicin4	-0.366	-0.398
Ethambutol3	0.435	2.393
Meropenem3	0.28	0.652
Vancomycin16	-0.316	-0.096
Rv2680_day32	0.504	1.396
H37Rv_KO_MarP	0.296	0.306
hypoxia_3wks	0.187	0.187
hypoxia_6wks	0.263	0.236
glycerol	0.17	0.767
cholesterol	0.084	0.272
AJ	0.588	0.635
Bibs02	0.295	0.045
Bibs02c	0.717	0.499
BL6	0.165	-0.08
BL6a	0.283	0.346
BXD01	0.175	0.259
BXD010	-0.481	-0.77
BXD011	-0.239	0.054
BXD03	0.167	0.329
BXD04	-0.105	-0.094
BXD05	0.408	0.052
BXD06	0.15	-0.024
BXD07	0.112	0.196
BXD08	0.673	-0.231
BXD09	-0.009	-0.547
CAST	0.207	0.627
CCcont	0.125	0.037
DS01	0.144	-0.139
DS02	0.63	-0.274
DS04	0.63	0.364
DS0c	0.848	0.009
GP01	-0.262	-0.302
GP02	0.262	0.915
GP0c	-0.273	0.219
NOD	-0.145	-0.116
NZO	0.173	0.386
PWK	0.078	0.22
H37Rv_KO_CtpC	0.318	0.305
H37Rv_KO_CtpD	1.464	1.534
H37Rv_KO_Rv1272	0.539	0.13
H37Rv_KO_SugABC	0.413	0.987
H37Rv_KO_MbtN	0.243	0.582
Trans05	0.063	0.136
macrophage_unactivated	0.038	0.846
IL1	-0.24	-0.442
Rapamycin	-0.181	0.322
Tcell	0.147	-0.44
GMCSF	0.293	-0.143
IFNab	0.426	-0.759
IFNg	0.088	0.043
IFNg_GMCSF1	0.167	0.459
Rv1432_day32	0.445	0.67
Rv1565c_day32	0.028	-0.924
secA2_input	-0.319	-0.348
delta_Rv3594	0.314	-0.791
delta_Rv3717	0.033	-0.395
delta_Rv3811	0.226	-0.714
delta_Rv0954	-0.277	-1.23
PonA1	0.035	-0.491
EccD1_KO	-0.283	0.089
EspI_KO	0.108	-0.391
PE35_KO	-0.055	0.07
PPE68_KO	0.035	-0.243
glycerol2	0.391	0.647
lignocerate	0.431	0.549
oleate	0.449	0.275
phosphatidylcholine	0.286	0.37
acetate	-0.086	0.291
glucAc	-0.171	0.318
Rv0950ko	0.25	-0.039
Rv1096ko	-0.347	-0.196
Rv3684ko	0.0	0.17
delta_otsA_trehalose	-0.698	-0.057