TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv3275c/purE:

update plot	correlation	link to info on gene
Rv3601c/panD	(cc=0.5713)	info on Rv3601c/panD
Rv3052c/nrdI	(cc=0.4946)	info on Rv3052c/nrdI
Rv2130c/mshC	(cc=0.4457)	info on Rv2130c/mshC
Rv2483c/plsC	(cc=0.4451)	info on Rv2483c/plsC
Rv2392/cysH	(cc=0.4359)	info on Rv2392/cysH
Rv1208/gpgS	(cc=0.4178)	info on Rv1208/gpgS
Rv2391/sirA	(cc=0.4157)	info on Rv2391/sirA
Rv2288/-	(cc=0.4103)	info on Rv2288/-
Rv3276c/purK	(cc=0.4026)	info on Rv3276c/purK
Rv1407/fmu	(cc=0.3927)	info on Rv1407/fmu

Correlation of Rv3275c/purE with Rv3601c/panD

Normalized LFCs for Rv3275c/purE:
(description and provenance of datasets)

	Rv3275c/purE	Rv3601c/panD
Fe_supp_jason_reseq	0.0	0.0
low_pH_jason_reseq	0.0	0.0
NO_jason_reseq	0.0	0.0
B6_jason_reseq	0.0	0.0
MHCII_jason_reseq	0.0	0.0
Isoniazid02	0.0	0.0
Rifampicin4	0.0	0.374
Ethambutol3	0.0	0.168
Meropenem3	0.0	0.0
Vancomycin16	0.0	0.366
Rv2680_day32	-0.642	0.0
H37Rv_KO_MarP	0.371	-0.195
hypoxia_3wks	0.0	0.0
hypoxia_6wks	0.0	0.0
glycerol	0.0	0.0
cholesterol	0.614	0.0
AJ	0.637	0.0
Bibs02	0.0	0.0
Bibs02c	0.0	0.0
BL6	0.0	0.0
BL6a	0.0	0.0
BXD01	0.0	0.0
BXD010	0.0	0.0
BXD011	0.127	0.0
BXD03	0.0	0.0
BXD04	0.0	0.0
BXD05	0.256	0.0
BXD06	0.0	0.0
BXD07	0.0	0.0
BXD08	0.0	0.0
BXD09	0.0	0.0
CAST	0.0	0.0
CCcont	0.0	0.0
DS01	0.0	0.0
DS02	0.0	0.0
DS04	0.0	0.0
DS0c	0.0	0.0
GP01	0.0	0.0
GP02	0.083	0.0
GP0c	0.0	0.0
NOD	0.0	0.0
NZO	0.0	0.0
PWK	0.0	0.0
H37Rv_KO_CtpC	0.571	0.0
H37Rv_KO_CtpD	0.0	0.0
H37Rv_KO_Rv1272	0.0	0.0
H37Rv_KO_SugABC	0.0	0.0
H37Rv_KO_MbtN	1.349	0.0
Trans05	2.805	0.0
macrophage_unactivated	0.0	0.0
IL1	0.0	0.0
Rapamycin	0.0	0.0
Tcell	0.0	0.0
GMCSF	0.0	0.0
IFNab	0.0	0.0
IFNg	0.0	0.0
IFNg_GMCSF1	0.0	0.0
Rv1432_day32	0.0	0.0
Rv1565c_day32	0.0	0.0
secA2_input	0.504	-0.593
delta_Rv3594	0.211	0.0
delta_Rv3717	1.165	0.0
delta_Rv3811	0.0	0.0
delta_Rv0954	0.34	0.0
PonA1	0.0	0.304
EccD1_KO	0.0	-0.454
EspI_KO	0.0	-0.394
PE35_KO	2.473	3.454
PPE68_KO	0.841	1.731
glycerol2	0.0	0.0
lignocerate	0.0	0.0
oleate	0.0	0.0
phosphatidylcholine	0.0	0.0
acetate	0.437	0.0
glucAc	0.0	0.0
Rv0950ko	0.416	0.416
Rv1096ko	2.045	0.793
Rv3684ko	1.241	1.916
delta_otsA_trehalose	0.0	0.254