TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv3124/moaR1:

update plot	correlation	link to info on gene
Rv2816c/-	(cc=0.6126)	info on Rv2816c/-
Rv1520/-	(cc=0.5855)	info on Rv1520/-
Rv3429/PPE59	(cc=0.5392)	info on Rv3429/PPE59
Rv1896c/-	(cc=0.5317)	info on Rv1896c/-
Rv2276/cyp121	(cc=0.5145)	info on Rv2276/cyp121
Rv3383c/idsB	(cc=0.5015)	info on Rv3383c/idsB
Rv2342/-	(cc=0.4969)	info on Rv2342/-
Rv0798c/cfp29	(cc=0.4938)	info on Rv0798c/cfp29
Rv0309/-	(cc=0.493)	info on Rv0309/-
Rv2527/vapC17	(cc=0.4896)	info on Rv2527/vapC17

Correlation of Rv3124/moaR1 with Rv0798c/cfp29

Normalized LFCs for Rv3124/moaR1:
(description and provenance of datasets)

	Rv3124/moaR1	Rv0798c/cfp29
Fe_supp_jason_reseq	0.259	-1.043
low_pH_jason_reseq	0.806	1.091
NO_jason_reseq	0.252	0.076
B6_jason_reseq	-0.175	0.324
MHCII_jason_reseq	0.203	-0.12
Isoniazid02	0.124	0.095
Rifampicin4	-0.393	0.176
Ethambutol3	0.989	-0.17
Meropenem3	1.097	0.053
Vancomycin16	0.499	0.443
Rv2680_day32	1.338	1.292
H37Rv_KO_MarP	-0.102	-0.378
hypoxia_3wks	-0.323	-1.551
hypoxia_6wks	0.397	-1.416
glycerol	-0.051	-0.272
cholesterol	-0.708	-0.046
AJ	0.197	-0.151
Bibs02	0.971	1.044
Bibs02c	0.127	-0.79
BL6	0.982	0.346
BL6a	0.729	0.346
BXD01	1.054	0.984
BXD010	0.641	-0.605
BXD011	1.144	0.383
BXD03	0.623	0.272
BXD04	0.896	0.751
BXD05	0.941	1.058
BXD06	0.924	0.233
BXD07	0.95	0.841
BXD08	0.706	1.065
BXD09	1.104	0.853
CAST	0.472	1.23
CCcont	1.024	1.106
DS01	0.255	0.82
DS02	0.08	-0.217
DS04	0.024	-0.732
DS0c	0.377	0.702
GP01	0.561	-0.099
GP02	-0.552	-0.81
GP0c	0.154	-0.551
NOD	1.071	0.88
NZO	0.51	-1.15
PWK	0.806	-0.337
H37Rv_KO_CtpC	0.366	0.194
H37Rv_KO_CtpD	0.949	1.96
H37Rv_KO_Rv1272	1.189	0.284
H37Rv_KO_SugABC	1.435	-0.964
H37Rv_KO_MbtN	0.974	1.833
Trans05	0.734	1.581
macrophage_unactivated	0.65	1.016
IL1	0.098	-0.332
Rapamycin	0.298	-0.114
Tcell	0.414	0.857
GMCSF	-0.275	-0.296
IFNab	0.1	0.314
IFNg	-0.059	-0.984
IFNg_GMCSF1	0.368	-0.606
Rv1432_day32	-0.592	0.936
Rv1565c_day32	0.253	-0.381
secA2_input	-1.0	-0.593
delta_Rv3594	0.164	-0.535
delta_Rv3717	0.182	-0.583
delta_Rv3811	-0.062	0.739
delta_Rv0954	0.138	-0.318
PonA1	-0.032	-0.725
EccD1_KO	0.493	1.779
EspI_KO	0.627	1.791
PE35_KO	0.986	1.747
PPE68_KO	1.353	2.521
glycerol2	0.106	0.617
lignocerate	0.774	0.655
oleate	-0.068	0.162
phosphatidylcholine	0.468	0.81
acetate	0.535	0.19
glucAc	1.081	0.209
Rv0950ko	0.899	1.095
Rv1096ko	0.118	-0.181
Rv3684ko	0.373	0.547
delta_otsA_trehalose	0.853	0.803