TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv2998/-:

update plot	correlation	link to info on gene
Rv1508A/-	(cc=0.5325)	info on Rv1508A/-
Rv2492/-	(cc=0.5168)	info on Rv2492/-
Rv0691c/-	(cc=0.5138)	info on Rv0691c/-
Rv3138/pflA	(cc=0.5123)	info on Rv3138/pflA
Rv0567/-	(cc=0.4873)	info on Rv0567/-
Rv2310/-	(cc=0.4857)	info on Rv2310/-
Rv1269c/-	(cc=0.4854)	info on Rv1269c/-
Rv2880c/-	(cc=0.4774)	info on Rv2880c/-
Rv0934/pstS1	(cc=0.4497)	info on Rv0934/pstS1
Rv0557/mgtA	(cc=0.4462)	info on Rv0557/mgtA

Correlation of Rv2998/- with Rv2880c/-

Normalized LFCs for Rv2998/-:
(description and provenance of datasets)

	Rv2998/-	Rv2880c/-
Fe_supp_jason_reseq	0.0	-0.338
low_pH_jason_reseq	-1.074	-0.813
NO_jason_reseq	0.378	0.512
B6_jason_reseq	-0.74	0.677
MHCII_jason_reseq	0.621	0.254
Isoniazid02	-0.723	0.058
Rifampicin4	0.647	0.791
Ethambutol3	-0.373	0.495
Meropenem3	-1.329	-0.01
Vancomycin16	-0.568	0.615
Rv2680_day32	-2.766	-0.55
H37Rv_KO_MarP	0.401	0.065
hypoxia_3wks	0.044	-0.299
hypoxia_6wks	0.67	-1.002
glycerol	-0.357	-0.101
cholesterol	-0.07	-0.136
AJ	-0.015	0.168
Bibs02	-0.558	0.87
Bibs02c	0.571	0.915
BL6	0.368	0.319
BL6a	0.927	0.178
BXD01	0.66	-0.144
BXD010	-0.018	0.043
BXD011	0.008	-0.47
BXD03	0.289	0.121
BXD04	0.389	-0.023
BXD05	1.214	0.514
BXD06	0.642	-0.332
BXD07	0.769	0.328
BXD08	0.684	0.133
BXD09	0.576	0.187
CAST	0.137	0.11
CCcont	-0.389	-0.302
DS01	-0.536	0.392
DS02	-0.438	0.469
DS04	-0.208	0.937
DS0c	1.571	0.104
GP01	1.334	0.351
GP02	-0.538	-0.802
GP0c	-0.23	-0.251
NOD	-0.174	-0.138
NZO	-0.663	0.279
PWK	0.993	0.418
H37Rv_KO_CtpC	0.613	-0.062
H37Rv_KO_CtpD	1.171	0.341
H37Rv_KO_Rv1272	0.714	-0.253
H37Rv_KO_SugABC	-1.841	0.362
H37Rv_KO_MbtN	-1.256	-0.839
Trans05	0.127	0.25
macrophage_unactivated	0.877	-0.17
IL1	0.068	0.578
Rapamycin	0.071	0.16
Tcell	0.345	-0.381
GMCSF	1.085	0.285
IFNab	0.121	0.048
IFNg	0.535	0.289
IFNg_GMCSF1	0.214	0.867
Rv1432_day32	1.7	0.997
Rv1565c_day32	-0.381	0.27
secA2_input	-0.304	0.088
delta_Rv3594	-2.168	-1.169
delta_Rv3717	-1.986	-1.277
delta_Rv3811	-1.698	-1.097
delta_Rv0954	-1.265	-1.151
PonA1	-2.401	-0.733
EccD1_KO	1.214	0.115
EspI_KO	0.633	0.753
PE35_KO	1.896	0.907
PPE68_KO	1.609	0.653
glycerol2	0.371	0.179
lignocerate	-0.186	-0.018
oleate	0.74	0.252
phosphatidylcholine	0.577	0.081
acetate	-0.977	-0.434
glucAc	-1.121	-0.54
Rv0950ko	0.757	0.757
Rv1096ko	1.707	0.072
Rv3684ko	-0.242	0.0
delta_otsA_trehalose	-2.389	0.753