TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv2918c/glnD:

update plot	correlation	link to info on gene
Rv0731c/-	(cc=0.4799)	info on Rv0731c/-
Rv3787c/-	(cc=0.4611)	info on Rv3787c/-
Rv2649/-	(cc=0.4398)	info on Rv2649/-
Rv0796/-	(cc=0.4343)	info on Rv0796/-
Rv1567c/-	(cc=0.4315)	info on Rv1567c/-
Rv3836/-	(cc=0.4206)	info on Rv3836/-
Rv2797c/-	(cc=0.4163)	info on Rv2797c/-
Rv0671/lpqP	(cc=0.4161)	info on Rv0671/lpqP
Rv3187/-	(cc=0.4142)	info on Rv3187/-
Rv2479c/-	(cc=0.4049)	info on Rv2479c/-

Correlation of Rv2918c/glnD with Rv3187/-

Normalized LFCs for Rv2918c/glnD:
(description and provenance of datasets)

	Rv2918c/glnD	Rv3187/-
Fe_supp_jason_reseq	-1.279	-0.646
low_pH_jason_reseq	-0.825	-0.571
NO_jason_reseq	0.47	0.165
B6_jason_reseq	-0.138	-0.598
MHCII_jason_reseq	0.079	-0.095
Isoniazid02	-0.087	-0.122
Rifampicin4	-0.301	0.59
Ethambutol3	-0.162	0.37
Meropenem3	0.661	-0.48
Vancomycin16	0.05	-0.318
Rv2680_day32	-0.459	0.127
H37Rv_KO_MarP	0.449	-0.147
hypoxia_3wks	0.159	0.494
hypoxia_6wks	0.464	0.031
glycerol	-0.718	-0.772
cholesterol	-0.09	0.125
AJ	0.597	1.301
Bibs02	0.125	1.102
Bibs02c	0.887	1.544
BL6	0.176	0.171
BL6a	0.446	0.954
BXD01	-0.794	0.523
BXD010	-0.286	0.722
BXD011	-0.106	0.739
BXD03	0.44	0.722
BXD04	-0.202	0.458
BXD05	0.891	0.933
BXD06	-0.349	0.424
BXD07	-0.615	0.835
BXD08	-0.86	0.411
BXD09	-0.245	0.642
CAST	1.036	1.078
CCcont	-0.553	-0.034
DS01	0.248	0.739
DS02	0.577	0.788
DS04	-0.294	1.003
DS0c	1.018	0.919
GP01	0.425	1.172
GP02	1.02	1.381
GP0c	-0.04	0.613
NOD	0.374	1.222
NZO	0.692	1.017
PWK	0.791	1.206
H37Rv_KO_CtpC	0.505	0.725
H37Rv_KO_CtpD	0.11	0.739
H37Rv_KO_Rv1272	-1.022	0.516
H37Rv_KO_SugABC	0.521	0.718
H37Rv_KO_MbtN	0.207	0.54
Trans05	-0.292	0.823
macrophage_unactivated	-0.413	-0.609
IL1	0.225	-0.38
Rapamycin	-0.675	-0.371
Tcell	-0.485	-0.951
GMCSF	-0.127	-0.069
IFNab	0.0	-0.883
IFNg	-0.043	-0.211
IFNg_GMCSF1	0.556	-0.104
Rv1432_day32	-0.196	0.443
Rv1565c_day32	-1.392	0.073
secA2_input	-0.601	0.202
delta_Rv3594	0.076	-0.118
delta_Rv3717	0.546	-0.234
delta_Rv3811	0.589	-0.012
delta_Rv0954	1.028	0.368
PonA1	0.585	0.047
EccD1_KO	-0.431	-0.023
EspI_KO	-1.124	0.856
PE35_KO	-0.382	0.712
PPE68_KO	-0.883	0.579
glycerol2	-0.198	-0.961
lignocerate	-0.217	-0.745
oleate	-0.805	-1.15
phosphatidylcholine	-0.661	-0.916
acetate	-0.494	-0.163
glucAc	-0.265	0.088
Rv0950ko	0.289	0.229
Rv1096ko	-0.184	0.712
Rv3684ko	-1.005	-0.364
delta_otsA_trehalose	0.177	-0.052