TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv2819c/-:

update plot	correlation	link to info on gene
Rv2648/-	(cc=0.5434)	info on Rv2648/-
Rv2267c/-	(cc=0.5401)	info on Rv2267c/-
Rv2512c/-	(cc=0.5268)	info on Rv2512c/-
Rv1948c/-	(cc=0.5251)	info on Rv1948c/-
Rv1199c/-	(cc=0.5245)	info on Rv1199c/-
Rv2276/cyp121	(cc=0.5088)	info on Rv2276/cyp121
Rv1498c/-	(cc=0.4979)	info on Rv1498c/-
Rv3784/-	(cc=0.4932)	info on Rv3784/-
Rv3490/otsA	(cc=0.4922)	info on Rv3490/otsA
Rv2809/-	(cc=0.4922)	info on Rv2809/-

Correlation of Rv2819c/- with Rv3490/otsA

Normalized LFCs for Rv2819c/-:
(description and provenance of datasets)

	Rv2819c/-	Rv3490/otsA
Fe_supp_jason_reseq	0.257	0.0
low_pH_jason_reseq	-0.032	0.0
NO_jason_reseq	0.05	0.0
B6_jason_reseq	0.083	0.0
MHCII_jason_reseq	0.392	0.0
Isoniazid02	-0.18	-0.383
Rifampicin4	0.406	0.601
Ethambutol3	1.216	0.14
Meropenem3	-0.2	-0.151
Vancomycin16	0.255	1.101
Rv2680_day32	0.526	0.0
H37Rv_KO_MarP	-0.255	-0.151
hypoxia_3wks	-0.506	0.0
hypoxia_6wks	-0.196	0.0
glycerol	0.149	0.202
cholesterol	0.49	0.276
AJ	1.397	0.0
Bibs02	0.449	0.0
Bibs02c	1.205	0.0
BL6	0.652	0.0
BL6a	1.124	0.0
BXD01	0.761	0.0
BXD010	0.543	0.0
BXD011	0.591	0.0
BXD03	0.755	0.0
BXD04	0.498	0.0
BXD05	0.611	0.0
BXD06	0.757	0.0
BXD07	0.642	0.0
BXD08	0.294	0.0
BXD09	0.652	0.0
CAST	0.48	0.0
CCcont	0.938	0.285
DS01	1.025	0.0
DS02	0.312	0.0
DS04	-0.122	0.0
DS0c	1.152	0.0
GP01	0.958	0.0
GP02	1.04	0.0
GP0c	0.714	0.0
NOD	0.858	0.0
NZO	0.653	0.0
PWK	2.593	0.0
H37Rv_KO_CtpC	0.992	0.0
H37Rv_KO_CtpD	-0.144	0.0
H37Rv_KO_Rv1272	0.774	0.0
H37Rv_KO_SugABC	0.194	0.0
H37Rv_KO_MbtN	1.627	0.0
Trans05	1.227	0.0
macrophage_unactivated	-0.205	0.0
IL1	-0.193	0.0
Rapamycin	0.374	0.0
Tcell	0.202	0.0
GMCSF	0.164	0.0
IFNab	0.0	0.0
IFNg	-0.219	0.0
IFNg_GMCSF1	0.148	0.0
Rv1432_day32	0.87	0.0
Rv1565c_day32	-0.935	0.0
secA2_input	-1.116	-0.916
delta_Rv3594	0.0	0.0
delta_Rv3717	-0.292	0.0
delta_Rv3811	0.085	0.0
delta_Rv0954	-1.056	0.0
PonA1	-0.464	0.0
EccD1_KO	0.378	-1.145
EspI_KO	0.516	0.55
PE35_KO	2.106	1.706
PPE68_KO	1.769	0.896
glycerol2	1.002	0.0
lignocerate	1.189	0.0
oleate	0.438	0.0
phosphatidylcholine	1.028	0.0
acetate	1.107	0.229
glucAc	0.709	0.392
Rv0950ko	-1.013	-0.844
Rv1096ko	-0.805	-1.517
Rv3684ko	-1.336	-0.917
delta_otsA_trehalose	-0.851	0.0