TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv2693c/-:

update plot	correlation	link to info on gene
Rv0387c/-	(cc=0.4885)	info on Rv0387c/-
Rv1755c/plcD	(cc=0.4826)	info on Rv1755c/plcD
Rv0312/-	(cc=0.4685)	info on Rv0312/-
Rv1634/-	(cc=0.4685)	info on Rv1634/-
Rv2265/-	(cc=0.4672)	info on Rv2265/-
Rv3705A/-	(cc=0.4491)	info on Rv3705A/-
Rv3776/-	(cc=0.4458)	info on Rv3776/-
Rv0207c/-	(cc=0.4402)	info on Rv0207c/-
Rv0593/lprL	(cc=0.4313)	info on Rv0593/lprL
Rv1394c/cyp132	(cc=0.4281)	info on Rv1394c/cyp132

Correlation of Rv2693c/- with Rv0387c/-

Normalized LFCs for Rv2693c/-:
(description and provenance of datasets)

	Rv2693c/-	Rv0387c/-
Fe_supp_jason_reseq	0.349	0.197
low_pH_jason_reseq	1.193	-0.268
NO_jason_reseq	0.113	-0.297
B6_jason_reseq	-0.112	0.51
MHCII_jason_reseq	0.999	1.019
Isoniazid02	0.249	-0.33
Rifampicin4	-0.899	-0.615
Ethambutol3	1.888	0.79
Meropenem3	-1.457	-0.49
Vancomycin16	-0.573	-0.462
Rv2680_day32	0.363	-0.501
H37Rv_KO_MarP	-0.068	0.358
hypoxia_3wks	-1.982	-0.104
hypoxia_6wks	-0.768	-0.645
glycerol	0.699	0.851
cholesterol	-0.177	0.193
AJ	0.059	0.639
Bibs02	0.476	1.025
Bibs02c	-0.111	0.199
BL6	0.45	0.67
BL6a	-0.052	0.286
BXD01	-0.652	-0.016
BXD010	-0.526	0.128
BXD011	-0.806	-0.056
BXD03	-1.174	-0.216
BXD04	-0.711	0.192
BXD05	0.108	0.451
BXD06	-0.6	-0.223
BXD07	-0.18	-0.115
BXD08	0.009	0.088
BXD09	-0.703	0.035
CAST	-0.315	-0.506
CCcont	-0.068	0.116
DS01	0.672	0.072
DS02	0.069	1.015
DS04	0.278	0.32
DS0c	0.531	0.324
GP01	-0.242	-0.012
GP02	0.837	-0.305
GP0c	1.054	0.301
NOD	-0.443	1.064
NZO	-0.091	0.049
PWK	-0.806	0.107
H37Rv_KO_CtpC	0.562	-0.485
H37Rv_KO_CtpD	0.336	0.236
H37Rv_KO_Rv1272	-0.54	-0.457
H37Rv_KO_SugABC	-0.724	-0.354
H37Rv_KO_MbtN	1.07	-0.086
Trans05	0.3	0.079
macrophage_unactivated	0.597	-0.243
IL1	0.089	0.237
Rapamycin	-0.562	0.292
Tcell	-0.45	0.098
GMCSF	-0.364	0.705
IFNab	-0.348	0.33
IFNg	-0.337	0.508
IFNg_GMCSF1	-1.313	0.094
Rv1432_day32	-0.446	-0.063
Rv1565c_day32	1.674	0.734
secA2_input	-0.402	-0.92
delta_Rv3594	0.711	1.394
delta_Rv3717	0.356	1.179
delta_Rv3811	0.394	0.864
delta_Rv0954	-0.071	0.854
PonA1	0.367	0.859
EccD1_KO	-0.842	-0.339
EspI_KO	-0.394	-0.77
PE35_KO	-1.205	-1.065
PPE68_KO	-1.645	-0.864
glycerol2	0.61	0.785
lignocerate	1.46	1.145
oleate	-0.563	0.573
phosphatidylcholine	1.162	0.826
acetate	-0.045	0.708
glucAc	0.711	0.789
Rv0950ko	0.549	0.268
Rv1096ko	0.329	0.567
Rv3684ko	0.0	0.291
delta_otsA_trehalose	-0.468	1.148