TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv2635/-:

update plot	correlation	link to info on gene
Rv1735c/-	(cc=0.5288)	info on Rv1735c/-
Rv1064c/lpqV	(cc=0.5208)	info on Rv1064c/lpqV
Rv1519/-	(cc=0.5063)	info on Rv1519/-
Rv2506/-	(cc=0.503)	info on Rv2506/-
Rv0741/-	(cc=0.4992)	info on Rv0741/-
Rv0817c/-	(cc=0.492)	info on Rv0817c/-
Rv1115/-	(cc=0.4812)	info on Rv1115/-
Rv2014/-	(cc=0.4713)	info on Rv2014/-
Rv1367c/-	(cc=0.4706)	info on Rv1367c/-
Rv0984/moaB2	(cc=0.4648)	info on Rv0984/moaB2

Correlation of Rv2635/- with Rv1367c/-

Normalized LFCs for Rv2635/-:
(description and provenance of datasets)

	Rv2635/-	Rv1367c/-
Fe_supp_jason_reseq	-0.039	-0.668
low_pH_jason_reseq	-0.169	-0.621
NO_jason_reseq	1.998	0.102
B6_jason_reseq	-0.98	0.32
MHCII_jason_reseq	-0.178	0.499
Isoniazid02	0.592	0.322
Rifampicin4	0.904	0.574
Ethambutol3	0.88	1.446
Meropenem3	-0.077	0.0
Vancomycin16	0.753	0.265
Rv2680_day32	0.0	-0.364
H37Rv_KO_MarP	0.251	0.176
hypoxia_3wks	0.638	0.136
hypoxia_6wks	0.044	-0.438
glycerol	-0.709	-0.073
cholesterol	-0.178	-0.132
AJ	-0.926	-0.314
Bibs02	-3.335	-0.845
Bibs02c	-1.622	-0.4
BL6	-2.406	-1.556
BL6a	-2.375	-0.476
BXD01	-0.09	-0.868
BXD010	-2.113	-0.751
BXD011	-1.23	-0.447
BXD03	0.969	-1.169
BXD04	-1.619	-0.891
BXD05	-2.332	-0.533
BXD06	-1.182	-0.746
BXD07	-1.66	-0.944
BXD08	-0.531	-0.416
BXD09	-0.431	-1.607
CAST	-1.346	-0.624
CCcont	-1.642	-1.029
DS01	-0.38	-0.156
DS02	-1.612	-0.044
DS04	0.876	-0.094
DS0c	-1.087	0.035
GP01	-0.837	-0.481
GP02	-1.518	0.1
GP0c	-1.008	-0.119
NOD	-0.843	0.026
NZO	0.364	0.329
PWK	-0.645	-0.655
H37Rv_KO_CtpC	-1.948	0.075
H37Rv_KO_CtpD	-1.658	-0.046
H37Rv_KO_Rv1272	0.986	-0.075
H37Rv_KO_SugABC	-1.485	-0.189
H37Rv_KO_MbtN	0.159	-1.426
Trans05	-0.186	0.417
macrophage_unactivated	0.35	-0.789
IL1	-3.141	-0.875
Rapamycin	-2.894	-1.154
Tcell	-0.391	-1.225
GMCSF	-3.126	-0.929
IFNab	-2.851	-1.433
IFNg	-3.164	-1.443
IFNg_GMCSF1	-1.747	-0.619
Rv1432_day32	-0.404	-0.593
Rv1565c_day32	0.231	0.485
secA2_input	0.18	0.842
delta_Rv3594	-0.615	-1.069
delta_Rv3717	-1.359	-0.668
delta_Rv3811	-1.164	-0.625
delta_Rv0954	-1.95	-0.756
PonA1	0.763	-1.04
EccD1_KO	-0.263	0.599
EspI_KO	1.072	0.345
PE35_KO	0.432	0.554
PPE68_KO	0.243	0.211
glycerol2	-0.349	0.448
lignocerate	-0.799	-0.057
oleate	0.688	0.595
phosphatidylcholine	-0.332	0.682
acetate	-1.925	-0.344
glucAc	-2.507	0.346
Rv0950ko	-1.276	-0.081
Rv1096ko	-0.633	0.106
Rv3684ko	-0.688	0.085
delta_otsA_trehalose	-0.7	-0.511