TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv1975/-:

update plot	correlation	link to info on gene
Rv3095/-	(cc=0.6165)	info on Rv3095/-
Rv2042c/-	(cc=0.5413)	info on Rv2042c/-
Rv0869c/moaA2	(cc=0.5107)	info on Rv0869c/moaA2
Rv2484c/-	(cc=0.5032)	info on Rv2484c/-
Rv2251/-	(cc=0.4965)	info on Rv2251/-
Rv2505c/fadD35	(cc=0.4924)	info on Rv2505c/fadD35
Rv3585/radA	(cc=0.4885)	info on Rv3585/radA
Rv1318c/-	(cc=0.4885)	info on Rv1318c/-
Rv2498c/citE	(cc=0.4843)	info on Rv2498c/citE
Rv2976c/ung	(cc=0.4787)	info on Rv2976c/ung

Correlation of Rv1975/- with Rv3095/-

Normalized LFCs for Rv1975/-:
(description and provenance of datasets)

	Rv1975/-	Rv3095/-
Fe_supp_jason_reseq	-0.128	0.399
low_pH_jason_reseq	-0.473	-1.804
NO_jason_reseq	0.517	0.037
B6_jason_reseq	0.133	0.274
MHCII_jason_reseq	0.415	0.739
Isoniazid02	0.096	-0.068
Rifampicin4	0.089	-0.187
Ethambutol3	1.943	0.94
Meropenem3	0.381	-0.261
Vancomycin16	0.257	0.539
Rv2680_day32	0.284	0.277
H37Rv_KO_MarP	0.117	-0.062
hypoxia_3wks	0.279	-0.63
hypoxia_6wks	0.363	-0.434
glycerol	1.173	-0.531
cholesterol	0.434	-0.387
AJ	-0.366	-0.171
Bibs02	0.417	0.327
Bibs02c	-0.32	-0.855
BL6	-0.777	-0.702
BL6a	-0.601	-0.893
BXD01	-0.199	-0.149
BXD010	0.253	0.246
BXD011	-0.238	-0.012
BXD03	-0.294	0.109
BXD04	-0.148	-0.305
BXD05	0.103	0.187
BXD06	0.049	0.562
BXD07	0.132	-0.443
BXD08	0.211	-0.009
BXD09	-0.091	-0.18
CAST	-0.397	-0.395
CCcont	-0.387	-0.498
DS01	0.375	-0.067
DS02	-0.312	0.213
DS04	-0.16	0.0
DS0c	0.321	-0.317
GP01	0.376	-0.534
GP02	0.865	0.547
GP0c	0.257	0.399
NOD	0.932	-0.129
NZO	-0.475	0.244
PWK	-0.101	-0.323
H37Rv_KO_CtpC	-0.02	-1.056
H37Rv_KO_CtpD	-0.384	-0.639
H37Rv_KO_Rv1272	-0.542	-1.327
H37Rv_KO_SugABC	-0.488	-2.181
H37Rv_KO_MbtN	-0.137	0.044
Trans05	0.064	0.392
macrophage_unactivated	0.492	-0.395
IL1	0.495	-0.092
Rapamycin	0.829	0.11
Tcell	-0.189	-0.368
GMCSF	0.602	0.451
IFNab	0.242	-0.209
IFNg	0.927	0.799
IFNg_GMCSF1	1.059	0.804
Rv1432_day32	-0.035	-0.609
Rv1565c_day32	-1.362	-2.044
secA2_input	0.142	-0.398
delta_Rv3594	-0.652	-0.361
delta_Rv3717	-0.482	-0.039
delta_Rv3811	-0.623	-0.416
delta_Rv0954	-0.39	-0.541
PonA1	-0.559	-0.177
EccD1_KO	0.483	0.826
EspI_KO	1.027	0.613
PE35_KO	0.907	0.373
PPE68_KO	0.976	-0.019
glycerol2	-0.597	-1.063
lignocerate	-0.597	-1.443
oleate	0.027	-0.875
phosphatidylcholine	-0.436	-0.952
acetate	-1.092	-0.826
glucAc	-0.891	-0.58
Rv0950ko	0.775	-0.015
Rv1096ko	0.452	-0.208
Rv3684ko	0.956	-0.517
delta_otsA_trehalose	-0.873	-1.212