TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv1398c/vapB10:

update plot	correlation	link to info on gene
Rv1430/PE16	(cc=0.4664)	info on Rv1430/PE16
Rv2792c/-	(cc=0.4533)	info on Rv2792c/-
Rv1962A/vapB35	(cc=0.4515)	info on Rv1962A/vapB35
Rv1505c/-	(cc=0.4461)	info on Rv1505c/-
Rv3166c/-	(cc=0.4167)	info on Rv3166c/-
Rv1954c/-	(cc=0.405)	info on Rv1954c/-
Rv2248/-	(cc=0.4039)	info on Rv2248/-
Rv3698/-	(cc=0.4008)	info on Rv3698/-
Rv2545/vapB18	(cc=0.4001)	info on Rv2545/vapB18
Rv2818c/-	(cc=0.3992)	info on Rv2818c/-

Correlation of Rv1398c/vapB10 with Rv2792c/-

Normalized LFCs for Rv1398c/vapB10:
(description and provenance of datasets)

	Rv1398c/vapB10	Rv2792c/-
Fe_supp_jason_reseq	-0.834	0.104
low_pH_jason_reseq	-0.773	-2.541
NO_jason_reseq	-0.189	0.646
B6_jason_reseq	-1.519	-2.183
MHCII_jason_reseq	0.368	-2.462
Isoniazid02	0.976	1.362
Rifampicin4	-1.018	0.19
Ethambutol3	1.727	2.607
Meropenem3	-0.223	-0.277
Vancomycin16	-0.305	0.69
Rv2680_day32	-0.968	0.259
H37Rv_KO_MarP	-0.59	0.313
hypoxia_3wks	0.622	0.786
hypoxia_6wks	-1.006	-0.081
glycerol	1.81	0.353
cholesterol	0.282	1.321
AJ	-0.373	-0.398
Bibs02	0.083	-0.456
Bibs02c	0.638	1.449
BL6	1.081	0.825
BL6a	0.763	2.274
BXD01	0.968	1.396
BXD010	0.777	1.793
BXD011	-0.125	2.015
BXD03	0.847	1.751
BXD04	0.663	0.972
BXD05	-0.159	2.023
BXD06	0.061	1.533
BXD07	0.93	1.892
BXD08	1.599	1.177
BXD09	0.359	1.337
CAST	0.085	0.999
CCcont	0.833	1.058
DS01	1.266	1.993
DS02	-0.654	0.134
DS04	1.114	1.845
DS0c	1.315	0.068
GP01	-1.062	1.446
GP02	0.618	1.964
GP0c	0.768	2.515
NOD	2.298	1.022
NZO	-0.808	-0.269
PWK	-0.449	-1.026
H37Rv_KO_CtpC	1.43	0.488
H37Rv_KO_CtpD	1.668	1.252
H37Rv_KO_Rv1272	1.593	2.241
H37Rv_KO_SugABC	-1.297	-1.047
H37Rv_KO_MbtN	-1.419	-0.539
Trans05	0.529	0.861
macrophage_unactivated	0.799	-0.142
IL1	0.575	-1.044
Rapamycin	0.534	0.555
Tcell	2.281	-0.567
GMCSF	-0.124	0.267
IFNab	0.556	-1.179
IFNg	0.676	0.82
IFNg_GMCSF1	0.179	0.091
Rv1432_day32	0.911	0.302
Rv1565c_day32	0.199	0.573
secA2_input	-1.766	0.454
delta_Rv3594	0.734	0.532
delta_Rv3717	-0.274	0.965
delta_Rv3811	0.819	0.518
delta_Rv0954	0.017	-0.404
PonA1	-0.375	-0.822
EccD1_KO	-0.747	-0.954
EspI_KO	-0.191	0.616
PE35_KO	1.219	0.443
PPE68_KO	1.245	-0.093
glycerol2	0.287	0.844
lignocerate	0.18	0.692
oleate	0.79	1.381
phosphatidylcholine	0.753	1.522
acetate	-0.166	0.204
glucAc	-0.53	0.152
Rv0950ko	0.084	-2.325
Rv1096ko	0.166	-0.271
Rv3684ko	-1.389	-2.06
delta_otsA_trehalose	0.099	0.847