TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv1132/-:

update plot	correlation	link to info on gene
Rv1431/-	(cc=0.4547)	info on Rv1431/-
Rv0813c/-	(cc=0.4416)	info on Rv0813c/-
Rv1233c/-	(cc=0.4202)	info on Rv1233c/-
Rv2404c/lepA	(cc=0.4014)	info on Rv2404c/lepA
Rv1114/vapC32	(cc=0.3998)	info on Rv1114/vapC32
Rv0210/-	(cc=0.3984)	info on Rv0210/-
Rv3479/-	(cc=0.3969)	info on Rv3479/-
Rv2530A/vapB39	(cc=0.3889)	info on Rv2530A/vapB39
Rv0829/-	(cc=0.3854)	info on Rv0829/-
Rv1977/-	(cc=0.3846)	info on Rv1977/-

Correlation of Rv1132/- with Rv0210/-

Normalized LFCs for Rv1132/-:
(description and provenance of datasets)

	Rv1132/-	Rv0210/-
Fe_supp_jason_reseq	-0.077	-0.843
low_pH_jason_reseq	-0.579	-0.348
NO_jason_reseq	0.517	-0.21
B6_jason_reseq	0.368	0.393
MHCII_jason_reseq	-0.653	0.495
Isoniazid02	0.185	0.396
Rifampicin4	0.06	0.246
Ethambutol3	-0.027	0.919
Meropenem3	1.06	0.391
Vancomycin16	0.393	0.422
Rv2680_day32	1.473	1.617
H37Rv_KO_MarP	0.868	-0.154
hypoxia_3wks	-0.056	0.471
hypoxia_6wks	0.219	0.954
glycerol	0.158	0.647
cholesterol	-0.998	-0.046
AJ	0.35	0.519
Bibs02	-0.265	0.633
Bibs02c	0.634	-0.277
BL6	-0.422	0.424
BL6a	0.755	-0.251
BXD01	-0.229	0.059
BXD010	0.37	0.287
BXD011	0.428	-0.482
BXD03	-0.012	0.359
BXD04	0.314	-0.486
BXD05	-0.181	0.189
BXD06	0.431	-0.028
BXD07	0.545	0.042
BXD08	0.2	-0.122
BXD09	-0.189	-0.272
CAST	0.292	-0.012
CCcont	-0.041	-0.096
DS01	-0.176	0.154
DS02	-0.707	0.629
DS04	0.246	0.0
DS0c	0.31	0.575
GP01	0.442	0.447
GP02	-0.559	0.724
GP0c	-0.648	0.269
NOD	0.267	0.885
NZO	-0.092	0.743
PWK	0.053	0.09
H37Rv_KO_CtpC	-0.153	-0.464
H37Rv_KO_CtpD	0.409	-0.088
H37Rv_KO_Rv1272	0.234	-0.196
H37Rv_KO_SugABC	0.704	1.002
H37Rv_KO_MbtN	-0.658	-0.486
Trans05	-0.67	-0.465
macrophage_unactivated	-0.789	0.0
IL1	0.875	0.469
Rapamycin	0.565	-0.12
Tcell	-0.218	-0.873
GMCSF	-0.209	-0.393
IFNab	-0.345	0.227
IFNg	0.668	-0.139
IFNg_GMCSF1	-0.471	0.273
Rv1432_day32	2.059	1.001
Rv1565c_day32	-0.368	-0.352
secA2_input	-0.867	-0.122
delta_Rv3594	1.557	0.872
delta_Rv3717	1.165	1.377
delta_Rv3811	1.405	1.013
delta_Rv0954	1.043	0.795
PonA1	0.908	1.181
EccD1_KO	0.125	0.388
EspI_KO	0.108	-0.285
PE35_KO	0.0	-0.458
PPE68_KO	0.182	-0.234
glycerol2	0.039	0.717
lignocerate	0.268	0.985
oleate	-0.299	0.621
phosphatidylcholine	0.258	0.581
acetate	0.446	0.228
glucAc	0.468	0.484
Rv0950ko	0.048	0.335
Rv1096ko	0.048	0.956
Rv3684ko	-0.223	0.115
delta_otsA_trehalose	-0.126	0.625