TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv1132/-:

update plot	correlation	link to info on gene
Rv1431/-	(cc=0.4547)	info on Rv1431/-
Rv0813c/-	(cc=0.4416)	info on Rv0813c/-
Rv1233c/-	(cc=0.4202)	info on Rv1233c/-
Rv2404c/lepA	(cc=0.4014)	info on Rv2404c/lepA
Rv1114/vapC32	(cc=0.3998)	info on Rv1114/vapC32
Rv0210/-	(cc=0.3984)	info on Rv0210/-
Rv3479/-	(cc=0.3969)	info on Rv3479/-
Rv2530A/vapB39	(cc=0.3889)	info on Rv2530A/vapB39
Rv0829/-	(cc=0.3854)	info on Rv0829/-
Rv1977/-	(cc=0.3846)	info on Rv1977/-

Correlation of Rv1132/- with Rv1431/-

Normalized LFCs for Rv1132/-:
(description and provenance of datasets)

	Rv1132/-	Rv1431/-
Fe_supp_jason_reseq	-0.077	1.705
low_pH_jason_reseq	-0.579	-0.413
NO_jason_reseq	0.517	0.646
B6_jason_reseq	0.368	1.166
MHCII_jason_reseq	-0.653	0.675
Isoniazid02	0.185	0.195
Rifampicin4	0.06	0.257
Ethambutol3	-0.027	0.311
Meropenem3	1.06	-0.086
Vancomycin16	0.393	0.584
Rv2680_day32	1.473	-0.045
H37Rv_KO_MarP	0.868	-0.394
hypoxia_3wks	-0.056	0.526
hypoxia_6wks	0.219	0.844
glycerol	0.158	-0.015
cholesterol	-0.998	-1.049
AJ	0.35	-0.052
Bibs02	-0.265	0.264
Bibs02c	0.634	1.147
BL6	-0.422	-0.009
BL6a	0.755	0.829
BXD01	-0.229	0.323
BXD010	0.37	0.368
BXD011	0.428	0.366
BXD03	-0.012	-0.168
BXD04	0.314	0.17
BXD05	-0.181	-0.225
BXD06	0.431	-0.212
BXD07	0.545	0.444
BXD08	0.2	0.029
BXD09	-0.189	-0.118
CAST	0.292	0.132
CCcont	-0.041	0.176
DS01	-0.176	0.086
DS02	-0.707	-0.254
DS04	0.246	-0.593
DS0c	0.31	0.031
GP01	0.442	-0.2
GP02	-0.559	-1.039
GP0c	-0.648	-0.797
NOD	0.267	0.081
NZO	-0.092	-0.201
PWK	0.053	0.257
H37Rv_KO_CtpC	-0.153	0.127
H37Rv_KO_CtpD	0.409	0.174
H37Rv_KO_Rv1272	0.234	0.583
H37Rv_KO_SugABC	0.704	0.036
H37Rv_KO_MbtN	-0.658	0.446
Trans05	-0.67	-0.521
macrophage_unactivated	-0.789	0.095
IL1	0.875	-0.377
Rapamycin	0.565	-0.856
Tcell	-0.218	-0.238
GMCSF	-0.209	-0.164
IFNab	-0.345	-0.284
IFNg	0.668	-0.251
IFNg_GMCSF1	-0.471	-0.471
Rv1432_day32	2.059	5.473
Rv1565c_day32	-0.368	0.087
secA2_input	-0.867	0.219
delta_Rv3594	1.557	0.676
delta_Rv3717	1.165	0.653
delta_Rv3811	1.405	0.88
delta_Rv0954	1.043	0.308
PonA1	0.908	0.12
EccD1_KO	0.125	0.654
EspI_KO	0.108	0.867
PE35_KO	0.0	1.21
PPE68_KO	0.182	1.414
glycerol2	0.039	-0.279
lignocerate	0.268	-0.077
oleate	-0.299	0.037
phosphatidylcholine	0.258	0.403
acetate	0.446	-0.105
glucAc	0.468	1.56
Rv0950ko	0.048	0.241
Rv1096ko	0.048	-0.169
Rv3684ko	-0.223	0.134
delta_otsA_trehalose	-0.126	-0.105