TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv1101c/-:

update plot	correlation	link to info on gene
Rv2724c/fadE20	(cc=0.6137)	info on Rv2724c/fadE20
Rv3775/lipE	(cc=0.5407)	info on Rv3775/lipE
Rv3233c/-	(cc=0.5139)	info on Rv3233c/-
Rv3205c/-	(cc=0.51)	info on Rv3205c/-
Rv2489c/-	(cc=0.5051)	info on Rv2489c/-
Rv1554/frdC	(cc=0.4946)	info on Rv1554/frdC
Rv1887/-	(cc=0.49)	info on Rv1887/-
Rv0999/-	(cc=0.49)	info on Rv0999/-
Rv1148c/-	(cc=0.4897)	info on Rv1148c/-
Rv3630/-	(cc=0.4848)	info on Rv3630/-

Correlation of Rv1101c/- with Rv2724c/fadE20

Normalized LFCs for Rv1101c/-:
(description and provenance of datasets)

	Rv1101c/-	Rv2724c/fadE20
Fe_supp_jason_reseq	-0.557	-0.052
low_pH_jason_reseq	-0.992	-0.571
NO_jason_reseq	-0.633	0.215
B6_jason_reseq	0.396	0.553
MHCII_jason_reseq	0.097	-0.271
Isoniazid02	-0.997	-0.431
Rifampicin4	-0.428	0.317
Ethambutol3	-1.253	-1.149
Meropenem3	-0.998	-1.343
Vancomycin16	-2.417	-0.69
Rv2680_day32	0.58	0.171
H37Rv_KO_MarP	0.516	0.282
hypoxia_3wks	1.16	0.315
hypoxia_6wks	1.086	0.808
glycerol	-0.111	-0.24
cholesterol	0.03	-0.028
AJ	-0.163	0.308
Bibs02	0.168	0.25
Bibs02c	0.74	0.467
BL6	-0.027	0.089
BL6a	0.32	0.288
BXD01	-0.137	0.361
BXD010	0.054	0.311
BXD011	-0.037	0.141
BXD03	-0.36	0.115
BXD04	-0.13	0.583
BXD05	0.48	0.583
BXD06	0.158	0.171
BXD07	-0.161	0.214
BXD08	0.088	0.082
BXD09	0.059	-0.129
CAST	0.387	0.639
CCcont	-0.14	-0.202
DS01	0.888	0.462
DS02	0.578	0.451
DS04	0.0	0.448
DS0c	0.222	0.432
GP01	-0.245	0.342
GP02	0.773	0.353
GP0c	0.063	-0.258
NOD	-0.21	0.801
NZO	0.569	0.397
PWK	-0.092	0.76
H37Rv_KO_CtpC	-0.51	0.145
H37Rv_KO_CtpD	0.375	0.258
H37Rv_KO_Rv1272	0.555	-0.206
H37Rv_KO_SugABC	1.071	0.621
H37Rv_KO_MbtN	0.735	-0.248
Trans05	0.867	0.185
macrophage_unactivated	-0.051	-0.398
IL1	-0.128	-0.288
Rapamycin	-0.098	-0.712
Tcell	-0.355	-0.482
GMCSF	-0.333	-0.94
IFNab	0.647	-0.209
IFNg	-0.029	-0.58
IFNg_GMCSF1	0.0	-0.352
Rv1432_day32	0.958	-0.039
Rv1565c_day32	0.861	0.319
secA2_input	-0.667	-0.579
delta_Rv3594	0.881	0.944
delta_Rv3717	0.813	0.439
delta_Rv3811	0.909	0.473
delta_Rv0954	0.789	0.731
PonA1	0.29	0.568
EccD1_KO	-0.049	-0.306
EspI_KO	0.411	0.305
PE35_KO	0.44	-0.207
PPE68_KO	0.259	-0.566
glycerol2	-0.935	-0.163
lignocerate	-0.76	-0.402
oleate	-0.153	0.381
phosphatidylcholine	-0.66	-0.3
acetate	-1.175	-0.816
glucAc	-0.837	-0.573
Rv0950ko	0.033	-0.054
Rv1096ko	-0.347	-0.739
Rv3684ko	0.74	0.059
delta_otsA_trehalose	0.238	-0.182