TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv0442c/PPE10:

update plot	correlation	link to info on gene
Rv1882c/-	(cc=0.5862)	info on Rv1882c/-
Rv2240c/-	(cc=0.5727)	info on Rv2240c/-
Rv2851c/-	(cc=0.5562)	info on Rv2851c/-
Rv3506/fadD17	(cc=0.5525)	info on Rv3506/fadD17
Rv3468c/-	(cc=0.5465)	info on Rv3468c/-
Rv2007c/fdxA	(cc=0.5354)	info on Rv2007c/fdxA
Rv1186c/-	(cc=0.5046)	info on Rv1186c/-
Rv1045/-	(cc=0.4965)	info on Rv1045/-
Rv1442/bisC	(cc=0.4914)	info on Rv1442/bisC
Rv1999c/-	(cc=0.491)	info on Rv1999c/-

Correlation of Rv0442c/PPE10 with Rv2851c/-

Normalized LFCs for Rv0442c/PPE10:
(description and provenance of datasets)

	Rv0442c/PPE10	Rv2851c/-
Fe_supp_jason_reseq	-0.26	-0.021
low_pH_jason_reseq	-0.221	-0.852
NO_jason_reseq	0.228	2.539
B6_jason_reseq	-0.059	0.843
MHCII_jason_reseq	-0.082	1.51
Isoniazid02	0.109	0.781
Rifampicin4	-0.089	-0.319
Ethambutol3	0.0	0.14
Meropenem3	0.127	0.478
Vancomycin16	-0.029	-0.653
Rv2680_day32	0.028	1.779
H37Rv_KO_MarP	0.285	0.562
hypoxia_3wks	-0.654	0.809
hypoxia_6wks	-0.038	0.472
glycerol	-0.518	0.884
cholesterol	-0.426	-1.323
AJ	0.121	-0.484
Bibs02	-0.469	0.0
Bibs02c	-0.082	-0.217
BL6	-0.557	0.463
BL6a	-0.298	0.08
BXD01	-0.367	0.373
BXD010	-0.524	0.052
BXD011	-0.383	0.149
BXD03	-0.879	-0.99
BXD04	-0.667	0.744
BXD05	-0.413	0.514
BXD06	-0.318	-0.091
BXD07	-0.313	-0.131
BXD08	0.158	0.589
BXD09	-0.343	1.403
CAST	-0.21	-1.333
CCcont	-0.393	0.612
DS01	-0.395	-0.517
DS02	0.395	1.549
DS04	-0.028	-0.632
DS0c	-0.413	0.635
GP01	0.024	2.288
GP02	1.034	0.201
GP0c	-0.278	1.225
NOD	0.286	-0.835
NZO	-0.289	0.533
PWK	-0.21	-0.776
H37Rv_KO_CtpC	-0.499	0.248
H37Rv_KO_CtpD	-0.397	0.484
H37Rv_KO_Rv1272	0.093	0.609
H37Rv_KO_SugABC	0.723	2.202
H37Rv_KO_MbtN	-0.35	1.314
Trans05	-0.849	1.236
macrophage_unactivated	-0.085	0.956
IL1	0.053	1.777
Rapamycin	0.135	2.55
Tcell	-0.209	1.033
GMCSF	0.383	1.067
IFNab	-0.281	0.051
IFNg	0.321	3.814
IFNg_GMCSF1	0.776	4.286
Rv1432_day32	0.31	1.601
Rv1565c_day32	-0.03	-0.31
secA2_input	-0.462	-0.56
delta_Rv3594	-0.04	0.716
delta_Rv3717	-0.054	0.405
delta_Rv3811	-0.69	0.882
delta_Rv0954	-0.554	0.031
PonA1	-0.576	-1.27
EccD1_KO	-0.312	0.789
EspI_KO	0.228	0.819
PE35_KO	-0.277	0.289
PPE68_KO	-0.179	0.451
glycerol2	0.345	3.544
lignocerate	0.928	3.187
oleate	-0.421	-1.418
phosphatidylcholine	0.536	3.27
acetate	0.618	2.809
glucAc	0.624	2.649
Rv0950ko	0.389	0.585
Rv1096ko	0.296	0.558
Rv3684ko	0.622	1.041
delta_otsA_trehalose	1.603	2.311