TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv0267/narU:

update plot	correlation	link to info on gene
Rv3765c/tcrX	(cc=0.5266)	info on Rv3765c/tcrX
Rv2882c/frr	(cc=0.4895)	info on Rv2882c/frr
Rv0166/fadD5	(cc=0.4889)	info on Rv0166/fadD5
Rv1425/-	(cc=0.4882)	info on Rv1425/-
Rv0701/rplC	(cc=0.4771)	info on Rv0701/rplC
Rv1813c/-	(cc=0.4758)	info on Rv1813c/-
Rv3673c/-	(cc=0.4732)	info on Rv3673c/-
Rv3858c/gltD	(cc=0.4535)	info on Rv3858c/gltD
Rv2678c/hemE	(cc=0.4508)	info on Rv2678c/hemE
Rv0434/-	(cc=0.4457)	info on Rv0434/-

Correlation of Rv0267/narU with Rv3765c/tcrX

Normalized LFCs for Rv0267/narU:
(description and provenance of datasets)

	Rv0267/narU	Rv3765c/tcrX
Fe_supp_jason_reseq	0.129	0.309
low_pH_jason_reseq	0.0	-0.256
NO_jason_reseq	0.176	-0.276
B6_jason_reseq	-0.212	0.547
MHCII_jason_reseq	-0.112	0.536
Isoniazid02	0.842	0.166
Rifampicin4	0.282	-0.108
Ethambutol3	0.531	0.463
Meropenem3	1.015	0.056
Vancomycin16	0.061	0.674
Rv2680_day32	0.264	-0.121
H37Rv_KO_MarP	0.779	0.282
hypoxia_3wks	-0.024	0.247
hypoxia_6wks	0.115	0.875
glycerol	0.222	0.372
cholesterol	0.229	0.151
AJ	0.64	0.776
Bibs02	-0.013	-0.287
Bibs02c	-0.318	0.84
BL6	0.393	0.725
BL6a	0.063	0.327
BXD01	-0.373	-0.104
BXD010	0.019	0.636
BXD011	-0.005	-0.211
BXD03	-0.02	0.176
BXD04	0.018	-0.185
BXD05	0.039	-0.118
BXD06	0.029	0.278
BXD07	0.152	0.233
BXD08	-0.111	-0.436
BXD09	0.113	0.09
CAST	0.269	0.315
CCcont	-0.055	-0.072
DS01	0.026	0.785
DS02	0.296	0.857
DS04	0.103	0.533
DS0c	0.259	0.668
GP01	0.749	1.007
GP02	1.154	1.229
GP0c	-0.429	-0.772
NOD	-0.143	0.264
NZO	0.419	1.123
PWK	-0.242	0.698
H37Rv_KO_CtpC	0.205	-0.591
H37Rv_KO_CtpD	0.474	0.573
H37Rv_KO_Rv1272	0.655	0.237
H37Rv_KO_SugABC	0.24	0.324
H37Rv_KO_MbtN	-1.302	-1.647
Trans05	0.669	0.789
macrophage_unactivated	-0.054	-0.489
IL1	0.027	-0.104
Rapamycin	-0.175	0.015
Tcell	-0.349	-0.557
GMCSF	-0.269	0.214
IFNab	0.127	-0.26
IFNg	-0.104	0.925
IFNg_GMCSF1	-0.364	-0.336
Rv1432_day32	0.701	0.49
Rv1565c_day32	0.212	-0.338
secA2_input	0.208	-1.263
delta_Rv3594	0.098	-0.115
delta_Rv3717	-0.497	-0.398
delta_Rv3811	-0.196	0.064
delta_Rv0954	0.116	-0.019
PonA1	0.418	0.335
EccD1_KO	-0.556	-0.71
EspI_KO	-1.232	-0.85
PE35_KO	-0.776	-0.449
PPE68_KO	-1.273	-0.953
glycerol2	0.263	0.44
lignocerate	0.01	0.852
oleate	1.021	0.363
phosphatidylcholine	0.364	0.517
acetate	0.432	1.39
glucAc	-0.187	1.109
Rv0950ko	0.636	-0.277
Rv1096ko	0.296	-0.262
Rv3684ko	-0.409	-0.301
delta_otsA_trehalose	-0.139	0.911