TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv0221/-:

update plot	correlation	link to info on gene
Rv0918/-	(cc=0.4923)	info on Rv0918/-
Rv0071/-	(cc=0.4739)	info on Rv0071/-
Rv2882c/frr	(cc=0.4731)	info on Rv2882c/frr
Rv2678c/hemE	(cc=0.4622)	info on Rv2678c/hemE
Rv3135/PPE50	(cc=0.4602)	info on Rv3135/PPE50
Rv3673c/-	(cc=0.455)	info on Rv3673c/-
Rv3858c/gltD	(cc=0.445)	info on Rv3858c/gltD
Rv3606c/folK	(cc=0.4331)	info on Rv3606c/folK
Rv3753c/-	(cc=0.4254)	info on Rv3753c/-
Rv3765c/tcrX	(cc=0.4185)	info on Rv3765c/tcrX

Correlation of Rv0221/- with Rv0918/-

Normalized LFCs for Rv0221/-:
(description and provenance of datasets)

	Rv0221/-	Rv0918/-
Fe_supp_jason_reseq	1.018	-0.019
low_pH_jason_reseq	0.264	-1.362
NO_jason_reseq	-0.252	0.459
B6_jason_reseq	1.237	0.781
MHCII_jason_reseq	1.549	1.154
Isoniazid02	0.627	0.112
Rifampicin4	0.07	-0.187
Ethambutol3	0.685	1.223
Meropenem3	0.208	0.839
Vancomycin16	0.239	0.424
Rv2680_day32	0.687	2.915
H37Rv_KO_MarP	0.524	1.067
hypoxia_3wks	0.195	-0.797
hypoxia_6wks	0.714	-0.042
glycerol	0.184	-0.554
cholesterol	-0.282	0.024
AJ	-0.198	1.316
Bibs02	0.025	0.02
Bibs02c	0.243	0.706
BL6	0.323	-0.325
BL6a	0.382	0.376
BXD01	-0.121	-0.509
BXD010	0.372	-0.297
BXD011	0.435	-1.106
BXD03	0.261	-0.644
BXD04	0.008	-1.75
BXD05	0.205	-1.395
BXD06	-0.066	-0.671
BXD07	0.065	-1.133
BXD08	0.33	-0.183
BXD09	0.341	-0.608
CAST	0.295	-0.133
CCcont	0.173	-0.571
DS01	0.4	0.065
DS02	-0.17	0.512
DS04	0.963	0.607
DS0c	0.143	1.031
GP01	-0.014	-2.828
GP02	-0.204	-1.939
GP0c	-0.848	-0.857
NOD	0.42	0.285
NZO	0.144	0.283
PWK	0.539	-0.033
H37Rv_KO_CtpC	0.394	0.238
H37Rv_KO_CtpD	0.193	-0.796
H37Rv_KO_Rv1272	0.129	-0.397
H37Rv_KO_SugABC	-0.504	-1.469
H37Rv_KO_MbtN	-0.057	-0.42
Trans05	-0.093	-0.428
macrophage_unactivated	-0.23	-1.341
IL1	0.273	-0.151
Rapamycin	0.325	-1.065
Tcell	-0.026	-1.342
GMCSF	0.061	0.605
IFNab	-0.145	-0.898
IFNg	0.382	-1.355
IFNg_GMCSF1	0.072	-0.531
Rv1432_day32	0.828	0.692
Rv1565c_day32	-0.344	-1.136
secA2_input	-0.207	-0.955
delta_Rv3594	-0.054	-0.561
delta_Rv3717	-0.537	0.466
delta_Rv3811	-0.522	0.474
delta_Rv0954	0.044	-0.557
PonA1	0.512	1.163
EccD1_KO	-1.043	-1.187
EspI_KO	-0.841	-2.028
PE35_KO	-0.668	-1.762
PPE68_KO	-0.63	-2.176
glycerol2	0.443	-0.39
lignocerate	0.75	0.0
oleate	0.339	-0.109
phosphatidylcholine	0.335	-0.297
acetate	0.151	-0.52
glucAc	0.282	0.224
Rv0950ko	0.103	0.169
Rv1096ko	0.621	1.098
Rv3684ko	0.075	0.734
delta_otsA_trehalose	-0.155	0.66