TB Genome Annotation Portal

Rv3288c (usfY)

Amino Acid Sequence

MGQIPPQPVRRVLPLMVVPGNGQKWRNRTETEEAMGDTYRDPVDHLRTTRPLAGESLIDVVHWPGYLLIVAGVVGGVGALAAFGTGHHAEGMTFGVVAIV
VTVVGLAWLAFEHRRIRKIADRWYTEHPEVRRQRLAG
(Nucleotide sequence available on KEGG)

Additional Information



ESSENTIALITY

MtbTnDB - interactive tool for exploring a database of published TnSeq datasets for Mtb

TnSeqCorr - genes with correlated TnSeq profiles across >100 conditions *new*

Classification Condition Strain Method Reference Notes
Non-Essential Sodium Oleate H37RvMA Gumbel Subhalaxmi Nambi Probability of Essentiality: 0.000000;
1 non-insertions in a row out of 10 sites
Non-Essential Lignoceric Acid H37RvMA Gumbel Subhalaxmi Nambi Probability of Essentiality: 0.000000;
1 non-insertions in a row out of 10 sites
Non-Essential Phosphatidylcholine H37RvMA Gumbel Subhalaxmi Nambi Probability of Essentiality: 0.000000;
1 non-insertions in a row out of 10 sites
Non-Essential minimal media + 0.1% glycerol H37RvMA Gumbel Griffin et al. (2011) Probability of Essentiality: 0.000000;
1 non-insertions in a row out of 11 sites
Non-Essential minimal media + 0.01% cholesterol H37RvMA Gumbel Griffin et al. (2011) Probability of Essentiality: 0.000000;
1 non-insertions in a row out of 11 sites
Non-Essential 7H10-glycerol H37RvMA TraSH Sassetti et al. (2003a)
Non-Essential C57BL/6J mice (8 weeks) H37RvMA TraSH Sassetti et al. (2003b) Hybridization Ratio: 2.02
Growth-Advantage 7H09/7H10 + rich media H37RvMA MotifHMM DeJesus et al. (2017) Fully saturated (14 reps).

TnSeq Data No data currently available.
  • No TnSeq data currently available for this Target.
RNASeq Data No data currently available.
  • No RNA-Seq data currently available for this Target.
Metabolomic Profiles No data currently available.
  • No Metabolomic data currently available for this Target.
Proteomic Data No data currently available.
  • No Proteomic data currently available for this Target.

Regulatory Relationships from Systems Biology
  • BioCyc

    Gene interactions based on ChIPSeq and Transcription Factor Over-Expression (TFOE) (Systems Biology)

    NOTE: Green edges represent the connected genes being classified as differentially essential as a result of the middle gene being knocked out. These interactions are inferred based on RNASeq.

    Interactions based on ChIPSeq data

  • Interactions based on ChIPSeq data (Minch et al. 2014)

    Interactions based on TFOE data (Rustad et al. 2014)



    TBCAP

    Tubculosis Community Annotation Project (
    Slayden et al., 2013)

    Rv3288c (usfY)

    PropertyValueCreatorEvidencePMIDComment
    InteractionRegulatory Rv3289cvashishtrvISAOperon (Functional linkage)
    MC. Reddy, K. Gokulan et al. Crystal structure of Mycobacterium tuberculosis LrpA, a leucine-responsive global regulator associated with starvation response. Protein Sci. 2008
    InteractionRegulatory Rv3289cvashishtrvISAOperon (Functional linkage)
    MC. Reddy, K. Gokulan et al. Crystal structure of Mycobacterium tuberculosis LrpA, a leucine-responsive global regulator associated with starvation response. Protein Sci. 2008
    InteractionRegulatory Rv3290cvashishtrvISAOperon (Functional linkage)
    MC. Reddy, K. Gokulan et al. Crystal structure of Mycobacterium tuberculosis LrpA, a leucine-responsive global regulator associated with starvation response. Protein Sci. 2008
    InteractionRegulatory Rv3291cvashishtrvISAOperon (Functional linkage)
    MC. Reddy, K. Gokulan et al. Crystal structure of Mycobacterium tuberculosis LrpA, a leucine-responsive global regulator associated with starvation response. Protein Sci. 2008
    InteractionRegulatory Rv3289cshahanup86ISAOperon (Functional linkage)
    MC. Reddy, K. Gokulan et al. Crystal structure of Mycobacterium tuberculosis LrpA, a leucine-responsive global regulator associated with starvation response. Protein Sci. 2008
    CitationCrystal structure of Mycobacterium tuberculosis LrpA, a leucine-responsive global regulator associated with starvation response. MC. Reddy, K. Gokulan et al. Protein Sci. 2008shahanup86ISA18042675Operon (Functional linkage)
    InteractionRegulatory Rv3289cshahanup86ISAOperon (Functional linkage)
    MC. Reddy, K. Gokulan et al. Crystal structure of Mycobacterium tuberculosis LrpA, a leucine-responsive global regulator associated with starvation response. Protein Sci. 2008
    InteractionRegulatory Rv3290cshahanup86ISAOperon (Functional linkage)
    MC. Reddy, K. Gokulan et al. Crystal structure of Mycobacterium tuberculosis LrpA, a leucine-responsive global regulator associated with starvation response. Protein Sci. 2008
    InteractionRegulatory Rv3291cshahanup86ISAOperon (Functional linkage)
    MC. Reddy, K. Gokulan et al. Crystal structure of Mycobacterium tuberculosis LrpA, a leucine-responsive global regulator associated with starvation response. Protein Sci. 2008
    CitationCrystal structure of Mycobacterium tuberculosis LrpA, a leucine-responsive global regulator associated with starvation response. MC. Reddy, K. Gokulan et al. Protein Sci. 2008vashishtrvISA18042675Operon (Functional linkage)

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